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Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice.
Ron-Harel N, Notarangelo G, Ghergurovich JM, et al. Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proc Natl Acad Sci U S A. 2018;115(52):13347-13352. doi:10.1073/pnas.1804149115PubMedGoogle ScholarDOI
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Childhood seizures and risk of psychiatric disorders in adolescence and early adulthood: a Danish nationwide cohort study.
Dreier JW, Pedersen CB, Cotsapas C, Christensen J. Childhood seizures and risk of psychiatric disorders in adolescence and early adulthood: a Danish nationwide cohort study. Lancet Child Adolesc Health. 2019;3(2):99-108. doi:10.1016/S2352-4642(18)30351-1PubMedGoogle ScholarDOI
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Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons.
Wamsley B, Jaglin XH, Favuzzi E, et al. Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons. Neuron. 2018;100(4):846-859.e7. doi:10.1016/j.neuron.2018.09.026Google ScholarPubMedDOI
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High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults.
Roider J, Maehara T, Ngoepe A, et al. High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults. Front Immunol. 2018;9:1975. doi:10.3389/fimmu.2018.01975Google ScholarPubMedDOI
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Effective Reserve: A Latent Variable to Improve Outcome Prediction in Stroke.
Schirmer MD, PhD MRE, PhD AVD, et al. Effective Reserve: A Latent Variable to Improve Outcome Prediction in Stroke. J Stroke Cerebrovasc Dis. 2019;28(1):63-69. doi:10.1016/j.jstrokecerebrovasdis.2018.09.003PubMedGoogle ScholarDOI
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Sex-Specific Association between Family History of Diabetes and Risk of Colorectal Cancer: Two Prospective Cohort Studies.
Ma W, Song M, Kværner AS, et al. Sex-Specific Association between Family History of Diabetes and Risk of Colorectal Cancer: Two Prospective Cohort Studies. Cancer Prev Res (Phila). 2018;11(9):535-544. doi:10.1158/1940-6207.CAPR-18-0159Google ScholarPubMedDOI
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Aging and neurodegeneration are associated with increased mutations in single human neurons.
Lodato MA, Rodin RE, Bohrson CL, et al. Aging and neurodegeneration are associated with increased mutations in single human neurons. Science. 2018;359(6375):555-559. doi:10.1126/science.aao4426PubMedGoogle ScholarDOI
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Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.
Medina-Gomez C, Kemp JP, Trajanoska K, et al. Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects. Am J Hum Genet. 2018;102(1):88-102. doi:10.1016/j.ajhg.2017.12.005Google ScholarPubMedDOI
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Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: cohort study based on longitudinal data from the Framingham Heart Study.
Staerk L, Wang B, Preis SR, et al. Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: cohort study based on longitudinal data from the Framingham Heart Study. BMJ. 2018;361:k1453. doi:10.1136/bmj.k1453Google ScholarPubMedDOI
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Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden.
Chalmers ZR, Connelly CF, Fabrizio D, et al. Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden. Genome Med. 2017;9(1):34. doi:10.1186/s13073-017-0424-2Google ScholarPubMedDOI
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

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In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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