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A genetic model for proximity labelling of the mammalian secretome.
Yang R, Meyer AS, Droujinine IA, et al. A genetic model for proximity labelling of the mammalian secretome. Open Biol. 2022;12(8):220149. doi:10.1098/rsob.220149Google ScholarPubMedDOI
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Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation.
Hall AW, Chaffin M, Roselli C, et al. Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation. Circ Genom Precis Med. 2020;13(6):e003085. doi:10.1161/CIRCGEN.120.003085Google ScholarPubMedDOI
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MAUDE: inferring expression changes in sorting-based CRISPR screens.
de Boer CG, Ray JP, Hacohen N, Regev A. MAUDE: inferring expression changes in sorting-based CRISPR screens. Genome Biol. 2020;21(1):134. doi:10.1186/s13059-020-02046-8Google ScholarPubMedDOI
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Modeling the Epigenetic Landscape in Plant Development.
Davila-Velderrain J, Caldu-Primo JL, Martinez-Garcia JC, Alvarez-Buylla ER. Modeling the Epigenetic Landscape in Plant Development. Methods Mol Biol. 2018;1819:357-383. doi:10.1007/978-1-4939-8618-7_17Google ScholarPubMedDOI
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Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression.
Mowery CT, Reyes JM, Cabal-Hierro L, et al. Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression. Cell Rep. 2018;25(7):1898-1911.e5. doi:10.1016/j.celrep.2018.10.061Google ScholarPubMedDOI
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PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics.
Zheng J, Richardson TG, Millard LAC, et al. PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics. Gigascience. 2018;7(8). doi:10.1093/gigascience/giy090Google ScholarPubMedDOI
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Support of association between BRD1 and both schizophrenia and bipolar affective disorder.
Nyegaard M, Severinsen JE, Als TD, et al. Support of association between BRD1 and both schizophrenia and bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet. 2010;153B(2):582-591. doi:10.1002/ajmg.b.31023Google ScholarPubMedDOI
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Chromatin-state discovery and genome annotation with ChromHMM.
Ernst J, Kellis M. Chromatin-state discovery and genome annotation with ChromHMM. Nat Protoc. 2017;12(12):2478-2492. doi:10.1038/nprot.2017.124Google ScholarPubMedDOI
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The promise of discovering population-specific disease-associated genes in South Asia.
Nakatsuka N, Moorjani P, Rai N, et al. The promise of discovering population-specific disease-associated genes in South Asia. Nat Genet. 2017;49(9):1403-1407. doi:10.1038/ng.3917Google ScholarPubMedDOI
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SnapShot: Chronic Lymphocytic Leukemia.
Hacken ET, Guièze R, Wu CJ. SnapShot: Chronic Lymphocytic Leukemia. Cancer Cell. 2017;32(5):716-716.e1. doi:10.1016/j.ccell.2017.10.015PubMedGoogle ScholarDOI
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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