Li Y, Calvo SE, Gutman R, Liu JS, Mootha VK. Expansion of biological pathways based on evolutionary inference. Cell. 2014;158(1):213-25. doi:10.1016/j.cell.2014.05.034.

Jain IH, Zazzeron L, Goli R, et al. Hypoxia as a therapy for mitochondrial disease. Science. 2016;352(6281):54-61. doi:10.1126/science.aad9642.

Bick AG, Calvo SE, Mootha VK. Evolutionary diversity of the mitochondrial calcium uniporter. Science. 2012;336(6083):886. doi:10.1126/science.1214977.

Kong X, Banks A, Liu T, et al. IRF4 is a key thermogenic transcriptional partner of PGC-1α. Cell. 2014;158(1):69-83. doi:10.1016/j.cell.2014.04.049.

Tran MT, Zsengeller ZK, Berg AH, et al. PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection. Nature. 2016;531(7595):528-32. doi:10.1038/nature17184.

Jain M, Nilsson R, Sharma S, et al. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science. 2012;336(6084):1040-4. doi:10.1126/science.1218595.

Ahola S, Isohanni P, Euro L, et al. Mitochondrial EFTs defects in juvenile-onset Leigh disease, ataxia, neuropathy, and optic atrophy. Neurology. 2014;83(8):743-51. doi:10.1212/WNL.0000000000000716.

Chouchani ET, Kazak L, Jedrychowski MP, et al. Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. Nature. 2016;532(7597):112-6. doi:10.1038/nature17399.

Hacisuleyman E, Cabili MN, Rinn JL. A Keystone for ncRNA. Genome Biol. 2012;13(5):315. doi:10.1186/gb-2012-13-5-315.

Liu Y, Asnani A, Zou L, et al. Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. Sci Transl Med. 2014;6(266):266ra170. doi:10.1126/scitranslmed.3010189.