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Substrate geometry affects population dynamics in a bacterial biofilm.
Postek W, Staśkiewicz K, Lilja E, Wacław B. Substrate geometry affects population dynamics in a bacterial biofilm. Proceedings of the National Academy of Sciences of the United States of America. 2024;121(17):e2315361121. doi:10.1073/pnas.2315361121DOIPubMedGoogle Scholar
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Aryl-diazonium salts offer a rapid and cost-efficient method to functionalize plastic microfluidic devices for increased immunoaffinity capture.
Rabe DC, Ho U, Choudhury A, et al. Aryl-diazonium salts offer a rapid and cost-efficient method to functionalize plastic microfluidic devices for increased immunoaffinity capture. Advanced materials technologies. 2023;8(16). doi:10.1002/admt.202300210DOIPubMedGoogle Scholar
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Reducing Cancer Cell Adhesion using Microtextured Surfaces.
McCue C, Atari A, Parks S, Tseng YY, Varanasi KK. Reducing Cancer Cell Adhesion using Microtextured Surfaces. Small (Weinheim an der Bergstrasse, Germany). 2023:e2302401. doi:10.1002/smll.202302401DOIPubMedGoogle Scholar
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Scaling by shrinking: empowering single-cell 'omics' with microfluidic devices.
Prakadan SM, Shalek AK, Weitz DA. Scaling by shrinking: empowering single-cell ’omics’ with microfluidic devices. Nat Rev Genet. 2017;18(6):345-361. doi:10.1038/nrg.2017.15DOIPubMedGoogle Scholar
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Microfluidic-based mini-metagenomics enables discovery of novel microbial lineages from complex environmental samples.
Yu FB, Blainey PC, Schulz F, Woyke T, Horowitz MA, Quake SR. Microfluidic-based mini-metagenomics enables discovery of novel microbial lineages from complex environmental samples. Elife. 2017;6. doi:10.7554/eLife.26580DOIPubMedGoogle Scholar
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Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility.
Yu M, Bardia A, Aceto N, et al. Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Science. 2014;345(6193):216-20. doi:10.1126/science.1253533DOIPubMedGoogle Scholar
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Microfluidic organs-on-chips.
Bhatia SN, Ingber DE. Microfluidic organs-on-chips. Nat Biotechnol. 2014;32(8):760-72. doi:10.1038/nbt.2989DOIPubMedGoogle Scholar
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High-Throughput Single-Cell Labeling (Hi-SCL) for RNA-Seq Using Drop-Based Microfluidics.
Rotem A, Ram O, Shoresh N, et al. High-Throughput Single-Cell Labeling (Hi-SCL) for RNA-Seq Using Drop-Based Microfluidics. PLoS One. 2015;10(5):e0116328. doi:10.1371/journal.pone.0116328DOIPubMedGoogle Scholar
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Development of a High-Throughput Functional Screen Using Nanowell-Assisted Cell Patterning.
Ozkumur AY, Goods BA, Love C. Development of a High-Throughput Functional Screen Using Nanowell-Assisted Cell Patterning. Small. 2015;11(36):4643-50. doi:10.1002/smll.201500674DOIPubMedGoogle Scholar
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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