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The role of Gdf5 regulatory regions in development of hip morphology.
Kiapour AM, Cao J, Young M, Capellini TD. The role of Gdf5 regulatory regions in development of hip morphology. PLoS One. 2018;13(11):e0202785. doi:10.1371/journal.pone.0202785DOIGoogle ScholarPubMed
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Anthrax lethal factor inhibition.
Shoop WL, Xiong Y, Wiltsie J, et al. Anthrax lethal factor inhibition. Proc Natl Acad Sci U S A. 2005;102(22):7958-63. doi:10.1073/pnas.0502159102DOIGoogle ScholarPubMed
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Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis.
Cottrell JR, Li B, Kyung JW, et al. Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis. J Biol Chem. 2016;291(4):1948-56. doi:10.1074/jbc.M115.705319DOIGoogle ScholarPubMed
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Quantitative Proteomic Profiling Reveals Novel Surface Antigens and Possible Vaccine Candidates.
Bark SKN, Ahmad R, Dantzler K, et al. Quantitative Proteomic Profiling Reveals Novel Surface Antigens and Possible Vaccine Candidates. Mol Cell Proteomics. 2018;17(1):43-60. doi:10.1074/mcp.RA117.000076DOIGoogle ScholarPubMed
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Deinococcus Mn-peptide complex: A novel approach to alphavirus vaccine development.
Gayen M, Gupta P, Morazzani EM, et al. Deinococcus Mn-peptide complex: A novel approach to alphavirus vaccine development. Vaccine. 2017;35(29):3672-3681. doi:10.1016/j.vaccine.2017.05.016DOIGoogle ScholarPubMed
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Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.
Kozono S, Lin YM, Seo HS, et al. Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018;9(1):3069. doi:10.1038/s41467-018-05402-2DOIGoogle ScholarPubMed
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Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming.
Schwarz BA, Cetinbas M, Clement K, et al. Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming. Cell Stem Cell. 2018;23(2):289-305.e5. doi:10.1016/j.stem.2018.06.013DOIGoogle ScholarPubMed
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The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress.
Zelikowsky M, Hui M, Karigo T, et al. The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress. Cell. 2018;173(5):1265-1279.e19. doi:10.1016/j.cell.2018.03.037DOIGoogle ScholarPubMed
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Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.
Martins MM, Zhou AY, Corella A, et al. Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map. Cancer Discov. 2015;5(2):154-67. doi:10.1158/2159-8290.CD-14-0552DOIGoogle ScholarPubMed
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Ectopic colonization of oral bacteria in the intestine drives T1 cell induction and inflammation.
Atarashi K, Suda W, Luo C, et al. Ectopic colonization of oral bacteria in the intestine drives T1 cell induction and inflammation. Science. 2017;358(6361):359-365. doi:10.1126/science.aan4526DOIGoogle ScholarPubMed
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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