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High-quality peptide evidence for annotating non-canonical open reading frames as human proteins.
Deutsch EW, Kok LW, Mudge JM, et al. High-quality peptide evidence for annotating non-canonical open reading frames as human proteins. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.09.09.612016DOIGoogle ScholarPubMed
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Phosphorothioate DNA modification by BREX Type 4 systems in the human gut microbiome.
Yuan Y, DeMott MS, Byrne SR, et al. Phosphorothioate DNA modification by BREX Type 4 systems in the human gut microbiome. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.06.03.597175DOIGoogle ScholarPubMed
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Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation.
Geffen Y, Anand S, Akiyama Y, et al. Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation. Cell. 2023. doi:10.1016/j.cell.2023.07.013DOIGoogle ScholarPubMed
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What can Ribo-seq, immunopeptidomics, and proteomics tell us about the non-canonical proteome?
Prensner JR, Abelin JG, Kok LW, et al. What can Ribo-seq, immunopeptidomics, and proteomics tell us about the non-canonical proteome?. Molecular & cellular proteomics : MCP. 2023:100631. doi:10.1016/j.mcpro.2023.100631DOIGoogle ScholarPubMed
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COVIDpro: Database for Mining Protein Dysregulation in Patients with COVID-19.
Zhang F, Luna A, Tan T, Chen Y, Sander C, Guo T. COVIDpro: Database for Mining Protein Dysregulation in Patients with COVID-19. Journal of proteome research. 2023. doi:10.1021/acs.jproteome.3c00092DOIGoogle ScholarPubMed
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HLA-I immunopeptidome profiling of human cells infected with high-containment enveloped viruses.
Weingarten-Gabbay S, Pearlman LR, Chen DY, et al. HLA-I immunopeptidome profiling of human cells infected with high-containment enveloped viruses. STAR Protoc. 2022;3(4):101910. doi:10.1016/j.xpro.2022.101910DOIGoogle ScholarPubMed
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A genetic model for proximity labelling of the mammalian secretome.
Yang R, Meyer AS, Droujinine IA, et al. A genetic model for proximity labelling of the mammalian secretome. Open Biol. 2022;12(8):220149. doi:10.1098/rsob.220149DOIGoogle ScholarPubMed
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Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis.
Krahmer N, Najafi B, Schueder F, et al. Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis. Dev Cell. 2018;47(2):205-221.e7. doi:10.1016/j.devcel.2018.09.017DOIGoogle ScholarPubMed
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Efficiency of database search for identification of mutated and modified proteins via mass spectrometry.
Pevzner PA, Mulyukov Z, Dančík V, Tang CL. Efficiency of database search for identification of mutated and modified proteins via mass spectrometry. Genome Res. 2001;11(2):290-9. doi:10.1101/gr.154101DOIGoogle ScholarPubMed
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Reproducible workflow for multiplexed deep-scale proteome and phosphoproteome analysis of tumor tissues by liquid chromatography-mass spectrometry.
Mertins P, Tang LC, Krug K, et al. Reproducible workflow for multiplexed deep-scale proteome and phosphoproteome analysis of tumor tissues by liquid chromatography-mass spectrometry. Nat Protoc. 2018;13(7):1632-1661. doi:10.1038/s41596-018-0006-9DOIGoogle ScholarPubMed
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

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In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

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Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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