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A Bayesian method for detecting pairwise associations in compositional data.
Schwager E, Mallick H, Ventz S, Huttenhower C. A Bayesian method for detecting pairwise associations in compositional data. PLoS Comput Biol. 2017;13(11):e1005852. doi:10.1371/journal.pcbi.1005852Google ScholarPubMedDOI
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A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer's Disease.
Wang X, Philip VM, Ananda G, et al. A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer’s Disease. Genetics. 2018;209(1):51-64. doi:10.1534/genetics.117.300673Google ScholarPubMedDOI
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Estimation for restriction sites observed by optical mapping using reversible-jump Markov Chain Monte Carlo.
Lee JK, Dančík V, Waterman MS. Estimation for restriction sites observed by optical mapping using reversible-jump Markov Chain Monte Carlo. J Comput Biol. 1998;5(3):505-15. doi:10.1089/cmb.1998.5.505PubMedGoogle ScholarDOI
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Selection of first-line therapy in multiple sclerosis using risk-benefit decision analysis.
Bargiela D, Bianchi MT, Westover B, et al. Selection of first-line therapy in multiple sclerosis using risk-benefit decision analysis. Neurology. 2017;88(7):677-684. doi:10.1212/WNL.0000000000003612Google ScholarPubMedDOI
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Genomic Analysis of Lassa Virus during an Increase in Cases in Nigeria in 2018.
Siddle KJ, Eromon P, Barnes KG, et al. Genomic Analysis of Lassa Virus during an Increase in Cases in Nigeria in 2018. N Engl J Med. 2018;379(18):1745-1753. doi:10.1056/NEJMoa1804498PubMedDOIGoogle Scholar
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Chromatin-state discovery and genome annotation with ChromHMM.
Ernst J, Kellis M. Chromatin-state discovery and genome annotation with ChromHMM. Nat Protoc. 2017;12(12):2478-2492. doi:10.1038/nprot.2017.124Google ScholarPubMedDOI
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Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs.
Korn JM, Kuruvilla FG, McCarroll SA, et al. Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs. Nat Genet. 2008;40(10):1253-60. doi:10.1038/ng.237PubMedDOIGoogle Scholar
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Conrad: gene prediction using conditional random fields.
DeCaprio D, Vinson JP, Pearson MD, Montgomery P, Doherty M, Galagan JE. Conrad: gene prediction using conditional random fields. Genome Res. 2007;17(9):1389-98. doi:10.1101/gr.6558107Google ScholarPubMedDOI
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Resource partitioning and sympatric differentiation among closely related bacterioplankton.
Hunt DE, David LA, Gevers D, Preheim SP, Alm EJ, Polz MF. Resource partitioning and sympatric differentiation among closely related bacterioplankton. Science. 2008;320(5879):1081-5. doi:10.1126/science.1157890PubMedGoogle ScholarDOI
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Fast and accurate inference of local ancestry in Latino populations.
Baran Y, Pasaniuc B, Sankararaman S, et al. Fast and accurate inference of local ancestry in Latino populations. Bioinformatics. 2012;28(10):1359-67. doi:10.1093/bioinformatics/bts144Google ScholarPubMedDOI
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

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In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

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Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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