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MalKinID: A Classification Model for Identifying Malaria Parasite Genealogical Relationships Using Identity-by-Descent.
Wong W, Wang L, Schaffner SS, et al. MalKinID: A Classification Model for Identifying Malaria Parasite Genealogical Relationships Using Identity-by-Descent. Genetics. 2024. doi:10.1093/genetics/iyae197Google ScholarPubMedDOI
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Infection length and host environment influence on Plasmodium falciparum dry season reservoir.
Andrade CM, Carrasquilla M, Dabbas U, et al. Infection length and host environment influence on Plasmodium falciparum dry season reservoir. EMBO molecular medicine. 2024. doi:10.1038/s44321-024-00127-wGoogle ScholarPubMedDOI
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Plasmodium infection induces phenotypic, clonal, and spatial diversity among differentiating CD4 T cells.
Williams CG, Moreira ML, Asatsuma T, et al. Plasmodium infection induces phenotypic, clonal, and spatial diversity among differentiating CD4 T cells. Cell reports. 2024;43(6):114317. doi:10.1016/j.celrep.2024.114317Google ScholarPubMedDOI
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Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine.
Senkpeil L, Bhardwaj J, Little MR, et al. Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine. JCI insight. 2024. doi:10.1172/jci.insight.167408Google ScholarPubMedDOI
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Temporal and spatial dynamics of clonal lineages in Guyana.
Vanhove M, Schwabl P, Clementson C, et al. Temporal and spatial dynamics of clonal lineages in Guyana. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.01.31.578156Google ScholarPubMedDOI
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Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites.
Lansink LIM, Skinner OP, Engel JA, et al. Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites. mBio. 2023:e0112923. doi:10.1128/mbio.01129-23Google ScholarPubMedDOI
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Macrophages drive KSHV B cell latency.
Szymula A, Samayoa-Reyes G, Ogolla S, et al. Macrophages drive KSHV B cell latency. Cell reports. 2023;42(7):112767. doi:10.1016/j.celrep.2023.112767Google ScholarPubMedDOI
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MalDA, Accelerating Malaria Drug Discovery.
Yang T, Ottilie S, Istvan ES, et al. MalDA, Accelerating Malaria Drug Discovery. Trends Parasitol. 2021;37(6):493-507. doi:10.1016/j.pt.2021.01.009Google ScholarPubMedDOI
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Declines in prevalence alter the optimal level of sexual investment for the malaria parasite Plasmodium falciparum.
Early AM, Camponovo F, Pelleau S, et al. Declines in prevalence alter the optimal level of sexual investment for the malaria parasite Plasmodium falciparum. Proc Natl Acad Sci U S A. 2022;119(30):e2122165119. doi:10.1073/pnas.2122165119Google ScholarPubMedDOI
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Mapping malaria by combining parasite genomic and epidemiologic data.
Wesolowski A, Taylor AR, Chang HH, et al. Mapping malaria by combining parasite genomic and epidemiologic data. BMC Med. 2018;16(1):190. doi:10.1186/s12916-018-1181-9Google ScholarPubMedDOI
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

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In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

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Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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