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Deep Learning-Based Detection of Carotid Plaques Informs Cardiovascular Risk Prediction and Reveals Genetic Drivers of Atherosclerosis.
Omarov M, Zhang L, Jorshery SD, et al. Deep Learning-Based Detection of Carotid Plaques Informs Cardiovascular Risk Prediction and Reveals Genetic Drivers of Atherosclerosis. medRxiv : the preprint server for health sciences. 2024. doi:10.1101/2024.10.17.24315675PubMedDOIGoogle Scholar
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Ligand distances as key predictors of pathogenicity and function in NMDA receptors.
Montanucci L, Brünger T, Bhattarai N, et al. Ligand distances as key predictors of pathogenicity and function in NMDA receptors. Human molecular genetics. 2024. doi:10.1093/hmg/ddae156PubMedDOIGoogle Scholar
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Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation.
An AY, Acton E, Idoko OT, et al. Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation. EBioMedicine. 2024:105411. doi:10.1016/j.ebiom.2024.105411PubMedDOIGoogle Scholar
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Artificial Intelligence Algorithms in Cardiovascular Medicine: An Attainable Promise to Improve Patient Outcomes or an Inaccessible Investment?
Bota P, Thambiraj G, Bollepalli SC, Armoundas AA. Artificial Intelligence Algorithms in Cardiovascular Medicine: An Attainable Promise to Improve Patient Outcomes or an Inaccessible Investment?. Current cardiology reports. 2024. doi:10.1007/s11886-024-02146-yPubMedDOIGoogle Scholar
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Enhancing Suicide Risk Prediction With Polygenic Scores in Psychiatric Emergency Settings: Prospective Study.
Lee YH, Zhang Y, Kennedy CJ, et al. Enhancing Suicide Risk Prediction With Polygenic Scores in Psychiatric Emergency Settings: Prospective Study. JMIR bioinformatics and biotechnology. 2024;5:e58357. doi:10.2196/58357PubMedDOIGoogle Scholar
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Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts.
Wani AH, Katrinli S, Zhao X, et al. Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts. BMC medical genomics. 2024;17(1):235. doi:10.1186/s12920-024-02002-6PubMedDOIGoogle Scholar
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Inter-organ cross-talk in human cancer cachexia revealed by spatial metabolomics.
Sun N, Krauss T, Seeliger C, et al. Inter-organ cross-talk in human cancer cachexia revealed by spatial metabolomics. Metabolism: clinical and experimental. 2024:156034. doi:10.1016/j.metabol.2024.156034PubMedDOIGoogle Scholar
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GOLDBAR: A Framework for Combinatorial Biological Design.
Roehner N, Roberts J, Lapets A, et al. GOLDBAR: A Framework for Combinatorial Biological Design. ACS synthetic biology. 2024. doi:10.1021/acssynbio.4c00296PubMedDOIGoogle Scholar
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GOLDBAR: A Framework for Combinatorial Biological Design.
Roehner N, Roberts J, Lapets A, et al. GOLDBAR: A Framework for Combinatorial Biological Design. ACS synthetic biology. 2024. doi:10.1021/acssynbio.4c00296PubMedDOIGoogle Scholar
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Evaluating predictors of kinase activity of STK11 variants identified in primary human non-small cell lung cancers.
Chen Y, Lee K, Woo J, et al. Evaluating predictors of kinase activity of STK11 variants identified in primary human non-small cell lung cancers. Research square. 2024. doi:10.21203/rs.3.rs-4587317/v1PubMedDOIGoogle Scholar
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

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In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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