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When Small Molecules Are Like Real Estate: It's All about Location, Location, Location.
DeRan M, Wagner BK. When Small Molecules Are Like Real Estate: It’s All about Location, Location, Location. Cell Chem Biol. 2018;25(10):1169-1170. doi:10.1016/j.chembiol.2018.10.004Google ScholarPubMedDOI
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Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.
Shen K, Sabatini DM. Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms. Proc Natl Acad Sci U S A. 2018;115(38):9545-9550. doi:10.1073/pnas.1811727115Google ScholarPubMedDOI
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SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance.
Liu K, Kong L, Graham DB, Carey KL, Xavier RJ. SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance. Cell Rep. 2021;36(4):109434. doi:10.1016/j.celrep.2021.109434Google ScholarPubMedDOI
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Progranulin in the hematopoietic compartment protects mice from atherosclerosis.
Nguyen AD, Nguyen TA, Singh RK, et al. Progranulin in the hematopoietic compartment protects mice from atherosclerosis. Atherosclerosis. 2018;277:145-154. doi:10.1016/j.atherosclerosis.2018.08.042Google ScholarPubMedDOI
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Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes.
Abu-Remaileh M, Wyant GA, Kim C, et al. Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes. Science. 2017;358(6364):807-813. doi:10.1126/science.aan6298Google ScholarPubMedDOI
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SAMTOR is an -adenosylmethionine sensor for the mTORC1 pathway.
Gu X, Orozco JM, Saxton RA, et al. SAMTOR is an -adenosylmethionine sensor for the mTORC1 pathway. Science. 2017;358(6364):813-818. doi:10.1126/science.aao3265Google ScholarPubMedDOI
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Mechanisms and function of autophagy in intestinal disease.
Lassen KG, Xavier RJ. Mechanisms and function of autophagy in intestinal disease. Autophagy. 2018;14(2):216-220. doi:10.1080/15548627.2017.1389358Google ScholarPubMedDOI
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Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy.
Dvela-Levitt M, Kost-Alimova M, Emani M, et al. Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy. Cell. 2019;178(3):521-535.e23. doi:10.1016/j.cell.2019.07.002Google ScholarPubMedDOI
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Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.
Nguyen AD, Nguyen TA, Zhang J, et al. Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay. Proc Natl Acad Sci U S A. 2018;115(12):E2849-E2858. doi:10.1073/pnas.1722344115Google ScholarPubMedDOI
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NUFIP1 is a ribosome receptor for starvation-induced ribophagy.
Wyant GA, Abu-Remaileh M, Frenkel EM, et al. NUFIP1 is a ribosome receptor for starvation-induced ribophagy. Science. 2018;360(6390):751-758. doi:10.1126/science.aar2663Google ScholarPubMedDOI
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

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In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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