Longevity

Brighter nights and darker days predict higher mortality risk: A prospective analysis of personal light exposure in >88,000 individuals.

Windred DP, Burns AC, Lane JM, et al. Brighter nights and darker days predict higher mortality risk: A prospective analysis of personal light exposure in >88,000 individuals. Proceedings of the National Academy of Sciences of the United States of America. 2024;121(43):e2405924121. doi:10.1073/pnas.2405924121PubMed DOI Google Scholar

Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies.

Tessier AJ, Wang F, Liang L, et al. Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies. Med (New York, N.Y.). 2024. doi:10.1016/j.medj.2024.01.010PubMed DOI Google Scholar

EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation.

Silva J, Aivio S, Knobel PA, et al. EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation. Nat Cell Biol. 2018;20(2):162-174. doi:10.1038/s41556-017-0016-9PubMed DOI Google Scholar

Quantitative analysis of population-scale family trees with millions of relatives.

Kaplanis J, Gordon A, Shor T, et al. Quantitative analysis of population-scale family trees with millions of relatives. Science. 2018;360(6385):171-175. doi:10.1126/science.aam9309PubMed DOI Google Scholar

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity.

Joshi PK, Pirastu N, Kentistou KA, et al. Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. Nat Commun. 2017;8(1):910. doi:10.1038/s41467-017-00934-5PubMed DOI Google Scholar

Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins.

Charles KN, Li MD, Engin F, Arruda AP, Inouye K, Hotamışlıgil GS. Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins. Cell Rep. 2017;21(2):393-402. doi:10.1016/j.celrep.2017.09.051PubMed DOI Google Scholar

Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy.

Naryshkin NA, Weetall M, Dakka A, et al. Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy. Science. 2014;345(6197):688-93. doi:10.1126/science.1250127PubMed DOI Google Scholar

Enrichment of longevity phenotype in mtDNA haplogroups D4b2b, D4a, and D5 in the Japanese population.

Alexe G, Fuku N, Bilal E, et al. Enrichment of longevity phenotype in mtDNA haplogroups D4b2b, D4a, and D5 in the Japanese population. Hum Genet. 2007;121(3-4):347-56. doi:10.1007/s00439-007-0330-6PubMed DOI Google Scholar

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

Yilmaz Ömer H, Katajisto P, Lamming DW, et al. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature. 2012;486(7404):490-5. doi:10.1038/nature11163PubMed DOI Google Scholar

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.

Lamming DW, Ye L, Astle CM, Baur JA, Sabatini DM, Harrison DE. Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive. Aging Cell. 2013;12(4):712-8. doi:10.1111/acel.12097PubMed DOI Google Scholar