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Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.
Dockendorff C, Faloon PW, Germain A, et al. Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. Bioorg Med Chem Lett. 2015;25(12):2594-8. doi:10.1016/j.bmcl.2015.03.074Google ScholarPubMedDOI
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Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer.
Rodriguez-Broadbent H, Law PJ, Sud A, et al. Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer. Int J Cancer. 2017;140(12):2701-2708. doi:10.1002/ijc.30709Google ScholarPubMedDOI
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Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity.
Joshi PK, Pirastu N, Kentistou KA, et al. Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. Nat Commun. 2017;8(1):910. doi:10.1038/s41467-017-00934-5Google ScholarPubMedDOI
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Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity.
Nieland TJF, Shaw JT, Jaipuri FA, et al. Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry. 2008;47(1):460-72. doi:10.1021/bi701277xGoogle ScholarPubMedDOI
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Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI.
Nieland TJF, Shaw JT, Jaipuri FA, et al. Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI. J Lipid Res. 2007;48(8):1832-45. doi:10.1194/jlr.M700209-JLR200Google ScholarPubMedDOI
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Exoplasmic cysteine Cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activity.
Yu M, Romer KA, Nieland TJF, et al. Exoplasmic cysteine Cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activity. Proc Natl Acad Sci U S A. 2011;108(30):12243-8. doi:10.1073/pnas.1109078108Google ScholarPubMedDOI
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APOL1 variants and kidney disease in people of recent African ancestry.
Genovese G, Friedman DJ, Pollak MR. APOL1 variants and kidney disease in people of recent African ancestry. Nat Rev Nephrol. 2013;9(4):240-4. doi:10.1038/nrneph.2013.34Google ScholarPubMedDOI
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Health disparities in kidney disease--emerging data from the human genome.
Williams WW, Pollak MR. Health disparities in kidney disease--emerging data from the human genome. N Engl J Med. 2013;369(23):2260-1. doi:10.1056/NEJMe1312797Google ScholarPubMedDOI
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Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1.
Nichols B, Jog P, Lee JH, et al. Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1. Kidney Int. 2015;87(2):332-42. doi:10.1038/ki.2014.270Google ScholarPubMedDOI
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Copy Number Variation at the APOL1 Locus.
Ruchi R, Genovese G, Lee J, et al. Copy Number Variation at the APOL1 Locus. PLoS One. 2015;10(5):e0125410. doi:10.1371/journal.pone.0125410Google ScholarPubMedDOI
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

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