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Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia.
Ott CJ, Federation AJ, Schwartz LS, et al. Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia. Cancer Cell. 2018;34(6):982-995.e7. doi:10.1016/j.ccell.2018.11.001PubMedGoogle ScholarDOI
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Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies.
Hacken ET, Valentin R, Regis FFD, et al. Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies. JCI Insight. 2018;3(19). doi:10.1172/jci.insight.121438PubMedGoogle ScholarDOI
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A cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens.
Hu Z, Anandappa AJ, Sun J, et al. A cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens. Blood. 2018;132(18):1911-1921. doi:10.1182/blood-2018-04-843763PubMedGoogle ScholarDOI
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Understanding CLL biology through mouse models of human genetics.
Hacken ET, Wu CJ. Understanding CLL biology through mouse models of human genetics. Blood. 2021;138(25):2621-2631. doi:10.1182/blood.2021011993PubMedGoogle ScholarDOI
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The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy.
Landau DA, Sun C, Rosebrock D, et al. The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy. Nat Commun. 2017;8(1):2185. doi:10.1038/s41467-017-02329-yPubMedGoogle ScholarDOI
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Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia.
Wang L, Fan J, Francis JM, et al. Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia. Genome Res. 2017;27(8):1300-1311. doi:10.1101/gr.217331.116PubMedGoogle ScholarDOI
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Analysis of rare germ line variants in chronic lymphocytic leukemia.
Tiao G, Improgo R, Tausch E, et al. Analysis of rare germ line variants in chronic lymphocytic leukemia. Blood. 2017;130(22):2443-2444. doi:10.1182/blood-2017-08-800128PubMedGoogle ScholarDOI
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SnapShot: Chronic Lymphocytic Leukemia.
Hacken ET, Guièze R, Wu CJ. SnapShot: Chronic Lymphocytic Leukemia. Cancer Cell. 2017;32(5):716-716.e1. doi:10.1016/j.ccell.2017.10.015PubMedGoogle ScholarDOI
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A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia.
Chen X, Gustafsson S, Whitington T, et al. A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia. Hum Mol Genet. 2018;27(10):1809-1818. doi:10.1093/hmg/ddy094PubMedGoogle ScholarDOI
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Clinical Implications of Novel Genomic Discoveries in Chronic Lymphocytic Leukemia.
Lazarian G, Guièze R, Wu CJ. Clinical Implications of Novel Genomic Discoveries in Chronic Lymphocytic Leukemia. J Clin Oncol. 2017;35(9):984-993. doi:10.1200/JCO.2016.71.0822PubMedGoogle ScholarDOI
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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