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Regulated GATA1 expression as a universal gene therapy for Diamond-Blackfan anemia.
Voit RA, Liao X, Caulier A, et al. Regulated GATA1 expression as a universal gene therapy for Diamond-Blackfan anemia. Cell stem cell. 2024. doi:10.1016/j.stem.2024.10.012PubMedDOIGoogle Scholar
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Modular vector assembly enables rapid assessment of emerging CRISPR technologies.
McGee A V, Liu Y V, Griffith AL, et al. Modular vector assembly enables rapid assessment of emerging CRISPR technologies. Cell genomics. 2024;4(3):100519. doi:10.1016/j.xgen.2024.100519PubMedDOIGoogle Scholar
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Getting Past HSC Security: Cyclosporine H Gives Lentiviruses an Entry Pass.
Bauer DE, Pai SY. Getting Past HSC Security: Cyclosporine H Gives Lentiviruses an Entry Pass. Cell Stem Cell. 2018;23(6):775-776. doi:10.1016/j.stem.2018.11.008PubMedDOIGoogle Scholar
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A case of mistaken identity.
Hanna RE, Doench JG. A case of mistaken identity. Nat Biotechnol. 2018;36(9):802-804. doi:10.1038/nbt.4208PubMedDOIGoogle Scholar
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Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens.
Hegde M, Strand C, Hanna RE, Doench JG. Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens. PLoS One. 2018;13(5):e0197547. doi:10.1371/journal.pone.0197547PubMedDOIGoogle Scholar
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CPF-DD is an inhibitor of infection by human immunodeficiency virus and other enveloped viruses in vitro.
Moore JP, Simpson G, McKeating JA, Burakoff SJ, Schreiber SL, Weiss RA. CPF-DD is an inhibitor of infection by human immunodeficiency virus and other enveloped viruses in vitro. Virology. 1992;188(2):537-44.PubMedGoogle Scholar
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Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening.
Joung J, Konermann S, Gootenberg JS, et al. Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening. Nat Protoc. 2017;12(4):828-863. doi:10.1038/nprot.2017.016PubMedDOIGoogle Scholar
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Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2.
Loebrich S, Djukic B, Tong ZJ, Cottrell JR, Turrigiano GG, Nedivi E. Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2. Proc Natl Acad Sci U S A. 2013;110(47):E4548-56. doi:10.1073/pnas.1318860110Google ScholarPubMedDOI
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Pooled Lentiviral-Delivery Genetic Screens.
Piccioni F, Younger ST, Root DE. Pooled Lentiviral-Delivery Genetic Screens. Curr Protoc Mol Biol. 2018;121:32.1.1-32.1.21. doi:10.1002/cpmb.52PubMedDOIGoogle Scholar
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Genome-scale loss-of-function screening with a lentiviral RNAi library.
Root DE, Hacohen N, Hahn WC, Lander ES, Sabatini DM. Genome-scale loss-of-function screening with a lentiviral RNAi library. Nat Methods. 2006;3(9):715-9. doi:10.1038/nmeth924PubMedDOIGoogle Scholar
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

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In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

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Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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