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Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?
Kaminski JA, Schlagenhauf F, Rapp M, et al. Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?. Transl Psychiatry. 2018;8(1):169. doi:10.1038/s41398-018-0222-7DOIGoogle ScholarPubMed
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A Polygenic Score for Higher Educational Attainment is Associated with Larger Brains.
Elliott ML, Belsky DW, Anderson K, et al. A Polygenic Score for Higher Educational Attainment is Associated with Larger Brains. Cereb Cortex. 2019;29(8):3496-3504. doi:10.1093/cercor/bhy219DOIGoogle ScholarPubMed
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Identification of Developmental and Behavioral Markers Associated With Genetic Abnormalities in Autism Spectrum Disorder.
Bishop SL, Farmer C, Bal V, et al. Identification of Developmental and Behavioral Markers Associated With Genetic Abnormalities in Autism Spectrum Disorder. Am J Psychiatry. 2017;174(6):576-585. doi:10.1176/appi.ajp.2017.16101115DOIGoogle ScholarPubMed
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Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders.
Weiner DJ, Wigdor EM, Ripke S, et al. Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders. Nat Genet. 2017;49(7):978-985. doi:10.1038/ng.3863DOIGoogle ScholarPubMed
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Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence.
Fernández E, Collins MO, Frank RAW, et al. Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence. Cell Rep. 2017;21(3):679-691. doi:10.1016/j.celrep.2017.09.045DOIGoogle ScholarPubMed
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Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.
Savage JE, Jansen PR, Stringer S, et al. Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nat Genet. 2018;50(7):912-919. doi:10.1038/s41588-018-0152-6DOIGoogle ScholarPubMed
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Evidence of Common Genetic Overlap Between Schizophrenia and Cognition.
Hubbard L, Tansey KE, Rai D, et al. Evidence of Common Genetic Overlap Between Schizophrenia and Cognition. Schizophr Bull. 2016;42(3):832-42. doi:10.1093/schbul/sbv168DOIGoogle ScholarPubMed
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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