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Query Chem: a Google-powered web search combining text and chemical structures.
Klekota J, Roth FP, Schreiber SL. Query Chem: a Google-powered web search combining text and chemical structures. Bioinformatics. 2006;22(13):1670-3. doi:10.1093/bioinformatics/btl155PubMedDOIGoogle Scholar
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A library of spirooxindoles based on a stereoselective three-component coupling reaction.
Lo MMC, Neumann CS, Nagayama S, Perlstein EO, Schreiber SL. A library of spirooxindoles based on a stereoselective three-component coupling reaction. J Am Chem Soc. 2004;126(49):16077-86. doi:10.1021/ja045089dPubMedDOIGoogle Scholar
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Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.
Youngsaye W, Dockendorff C, Vincent B, et al. Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles. Bioorg Med Chem Lett. 2012;22(9):3362-5. doi:10.1016/j.bmcl.2012.02.035PubMedDOIGoogle Scholar
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A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
Chen S, Borowiak M, Fox JL, et al. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009;5(4):258-65. doi:10.1038/nchembio.154PubMedDOIGoogle Scholar
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Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood.
Joung J, Engreitz JM, Konermann S, et al. Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood. Nature. 2017;548(7667):343-346. doi:10.1038/nature23451PubMedDOIGoogle Scholar
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Balancing selection shapes density-dependent foraging behaviour.
Greene JS, Brown M, Dobosiewicz M, et al. Balancing selection shapes density-dependent foraging behaviour. Nature. 2016;539(7628):254-258. doi:10.1038/nature19848PubMedDOIGoogle Scholar
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Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.
Wlodarska M, Luo C, Kolde R, et al. Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation. Cell Host Microbe. 2017;22(1):25-37.e6. doi:10.1016/j.chom.2017.06.007PubMedDOIGoogle Scholar
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Glycogen synthase kinase 3-β inhibition induces lymphangiogenesis through β-catenin-dependent and mTOR-independent pathways.
Stump B, Shrestha S, Lamattina AM, et al. Glycogen synthase kinase 3-β inhibition induces lymphangiogenesis through β-catenin-dependent and mTOR-independent pathways. PLoS One. 2019;14(4):e0213831. doi:10.1371/journal.pone.0213831PubMedDOIGoogle Scholar
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Using Automated Live Cell Imaging to Reveal Early Changes during Human Motor Neuron Degeneration.
Shin HY, Pfaff KL, Davidow LS, et al. Using Automated Live Cell Imaging to Reveal Early Changes during Human Motor Neuron Degeneration. eNeuro. 2018;5(3). doi:10.1523/ENEURO.0001-18.2018PubMedDOIGoogle Scholar
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Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity.
Posfai D, Eubanks AL, Keim AI, et al. Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity. Antimicrob Agents Chemother. 2018;62(4). doi:10.1128/AAC.01799-17PubMedDOIGoogle Scholar
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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