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Postmortem neuropathology in early Huntington disease.
Hedreen JC, Berretta S, White CL Iii. Postmortem neuropathology in early Huntington disease. Journal of neuropathology and experimental neurology. 2024. doi:10.1093/jnen/nlae022DOIPubMedGoogle Scholar
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Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages.
Floto A, Sarkar S, Perlstein EO, Kampmann B, Schreiber SL, Rubinsztein DC. Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington’s disease models and enhance killing of mycobacteria by macrophages. Autophagy. 2007;3(6):620-2.PubMedGoogle Scholar
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Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.
Sarkar S, Perlstein EO, Imarisio S, et al. Small molecules enhance autophagy and reduce toxicity in Huntington’s disease models. Nat Chem Biol. 2007;3(6):331-8. doi:10.1038/nchembio883DOIPubMedGoogle Scholar
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A modifier of Huntington's disease onset at the MLH1 locus.
Lee JM, Chao MJ, Harold D, et al. A modifier of Huntington’s disease onset at the MLH1 locus. Hum Mol Genet. 2017;26(19):3859-3867. doi:10.1093/hmg/ddx286DOIPubMedGoogle Scholar
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Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements.
Pirhaji L, Milani P, Dalin S, et al. Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements. Nat Commun. 2017;8(1):623. doi:10.1038/s41467-017-00353-6DOIPubMedGoogle Scholar
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Genetic Modification of Huntington Disease Acts Early in the Prediagnosis Phase.
Long JD, Lee JM, Aylward EH, et al. Genetic Modification of Huntington Disease Acts Early in the Prediagnosis Phase. Am J Hum Genet. 2018;103(3):349-357. doi:10.1016/j.ajhg.2018.07.017DOIPubMedGoogle Scholar
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Haplotype-based stratification of Huntington's disease.
Chao MJ, Gillis T, Atwal RS, et al. Haplotype-based stratification of Huntington’s disease. Eur J Hum Genet. 2017;25(11):1202-1209. doi:10.1038/ejhg.2017.125DOIPubMedGoogle Scholar
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Control of Huntington's Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2.
Hachigian LJ, Carmona V, Fenster RJ, et al. Control of Huntington’s Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2. Cell Rep. 2017;21(10):2688-2695. doi:10.1016/j.celrep.2017.11.018DOIPubMedGoogle Scholar
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Population-specific genetic modification of Huntington's disease in Venezuela.
Chao MJ, Kim KH, Shin JW, et al. Population-specific genetic modification of Huntington’s disease in Venezuela. PLoS Genet. 2018;14(5):e1007274. doi:10.1371/journal.pgen.1007274DOIPubMedGoogle Scholar
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Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region.
Lee JM, Gillis T, Mysore JS, et al. Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region. Am J Hum Genet. 2012;90(3):434-44. doi:10.1016/j.ajhg.2012.01.005DOIPubMedGoogle Scholar
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

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