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Editorial: Zoonotic diseases: epidemiology, multi-omics, and host-pathogen interactions.
Deng L, Yin H, Tan KSW, Tsaousis AD. Editorial: Zoonotic diseases: epidemiology, multi-omics, and host-pathogen interactions. Frontiers in microbiology. 2024;15:1454659. doi:10.3389/fmicb.2024.1454659DOIGoogle ScholarPubMed
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Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through B cell knockout models.
Hogan CH, Owens SM, Reynoso G V, et al. Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through B cell knockout models. mBio. 2024:e0299823. doi:10.1128/mbio.02998-23DOIGoogle ScholarPubMed
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Protease activity sensors noninvasively classify bacterial infections and antibiotic responses.
Buss CG, Dudani JS, Akana RTK, Fleming HE, Bhatia SN. Protease activity sensors noninvasively classify bacterial infections and antibiotic responses. EBioMedicine. 2018;38:248-256. doi:10.1016/j.ebiom.2018.11.031DOIGoogle ScholarPubMed
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Dissecting clinical outcome of porcine circovirus type 2 with in vivo derived transcriptomic signatures of host tissue responses.
Van Renne N, Wei R, Pochet N, Nauwynck HJ. Dissecting clinical outcome of porcine circovirus type 2 with in vivo derived transcriptomic signatures of host tissue responses. BMC Genomics. 2018;19(1):831. doi:10.1186/s12864-018-5217-5DOIGoogle ScholarPubMed
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Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of transcripts under balancing selection.
Ye CJ, Chen J, Villani AC, et al. Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of transcripts under balancing selection. Genome Res. 2018;28(12):1812-1825. doi:10.1101/gr.240390.118DOIGoogle ScholarPubMed
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Genomic insights into the host specific adaptation of the Pneumocystis genus.
Cissé OH, Ma L, Dekker JP, et al. Genomic insights into the host specific adaptation of the Pneumocystis genus. Commun Biol. 2021;4(1):305. doi:10.1038/s42003-021-01799-7DOIGoogle ScholarPubMed
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Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies.
Parada-Kusz M, Penaranda C, Hagedorn EJ, et al. Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies. Dis Model Mech. 2018;11(11). doi:10.1242/dmm.034876DOIGoogle ScholarPubMed
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Phagosomal Copper-Promoted Oxidative Attack on Intracellular Mycobacterium tuberculosis.
Libardo DJ, de la Fuente-Núñez C, Anand K, et al. Phagosomal Copper-Promoted Oxidative Attack on Intracellular Mycobacterium tuberculosis. ACS Infect Dis. 2018;4(11):1623-1634. doi:10.1021/acsinfecdis.8b00171DOIGoogle ScholarPubMed
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Epigenetic crossroads of the Epstein-Barr virus B-cell relationship.
Frost TC, Gewurz BE. Epigenetic crossroads of the Epstein-Barr virus B-cell relationship. Curr Opin Virol. 2018;32:15-23. doi:10.1016/j.coviro.2018.08.012DOIGoogle ScholarPubMed
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Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators.
Hommel B, Mukaremera L, Cordero RJB, et al. Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators. PLoS Pathog. 2018;14(5):e1006982. doi:10.1371/journal.ppat.1006982DOIGoogle ScholarPubMed
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

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In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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