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Circulating PACAP levels are associated with altered imaging measures of entorhinal cortex neurite density in posttraumatic stress disorder.
Granger SJ, May V, Hammack SE, et al. Circulating PACAP levels are associated with altered imaging measures of entorhinal cortex neurite density in posttraumatic stress disorder. European journal of psychotraumatology. 2024;15(1):2335793. doi:10.1080/20008066.2024.2335793PubMedDOIGoogle Scholar
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Circulating PACAP levels are associated with altered imaging measures of entorhinal cortex neurite density in posttraumatic stress disorder.
Granger SJ, May V, Hammack SE, et al. Circulating PACAP levels are associated with altered imaging measures of entorhinal cortex neurite density in posttraumatic stress disorder. European journal of psychotraumatology. 2024;15(1):2335793. doi:10.1080/20008066.2024.2335793PubMedDOIGoogle Scholar
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An inhibitory circuit-based enhancer of DYRK1A function reverses Dyrk1a-associated impairment in social recognition.
Shih YT, Alipio JB, Sahay A. An inhibitory circuit-based enhancer of DYRK1A function reverses Dyrk1a-associated impairment in social recognition. Neuron. 2023;111(19):3084-3101.e5. doi:10.1016/j.neuron.2023.09.009PubMedDOIGoogle Scholar
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Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models.
Brown EA, Lautz JD, Davis TR, et al. Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models. Mol Autism. 2018;9:48. doi:10.1186/s13229-018-0229-1PubMedDOIGoogle Scholar
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Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon.
Godbole G, Shetty AS, Roy A, et al. Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon. Development. 2018;145(1). doi:10.1242/dev.154583PubMedDOIGoogle Scholar
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Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline.
Yu L, Dawe RJ, Boyle PA, et al. Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline. JAMA Neurol. 2017;74(12):1473-1480. doi:10.1001/jamaneurol.2017.2807PubMedDOIGoogle Scholar
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Helicobacter pylori infection and low dietary iron alter behavior, induce iron deficiency anemia, and modulate hippocampal gene expression in female C57BL/6 mice.
Burns M, Amaya A, Bodi C, et al. Helicobacter pylori infection and low dietary iron alter behavior, induce iron deficiency anemia, and modulate hippocampal gene expression in female C57BL/6 mice. PLoS One. 2017;12(3):e0173108. doi:10.1371/journal.pone.0173108PubMedDOIGoogle Scholar
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Neural Circuits Serve as Periscopes for NSCs.
Guo N, Sahay A. Neural Circuits Serve as Periscopes for NSCs. Cell Stem Cell. 2017;21(5):557-559. doi:10.1016/j.stem.2017.10.007PubMedDOIGoogle Scholar
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AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.
Pan JQ, Lewis MC, Ketterman JK, et al. AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Neuropsychopharmacology. 2011;36(7):1397-411. doi:10.1038/npp.2011.24PubMedDOIGoogle Scholar
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Aging and neurodegeneration are associated with increased mutations in single human neurons.
Lodato MA, Rodin RE, Bohrson CL, et al. Aging and neurodegeneration are associated with increased mutations in single human neurons. Science. 2018;359(6375):555-559. doi:10.1126/science.aao4426PubMedDOIGoogle Scholar
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

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In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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