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Schizophrenia is Associated With an Aberrant Immune Response to Epstein-Barr Virus.
Dickerson F, Jones-Brando L, Ford G, et al. Schizophrenia is Associated With an Aberrant Immune Response to Epstein-Barr Virus. Schizophr Bull. 2019;45(5):1112-1119. doi:10.1093/schbul/sby164PubMedDOIGoogle Scholar
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Epigenetic crossroads of the Epstein-Barr virus B-cell relationship.
Frost TC, Gewurz BE. Epigenetic crossroads of the Epstein-Barr virus B-cell relationship. Curr Opin Virol. 2018;32:15-23. doi:10.1016/j.coviro.2018.08.012Google ScholarDOIPubMed
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CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors.
Ma Y, Walsh MJ, Bernhardt K, et al. CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors. Cell Host Microbe. 2017;21(5):580-591.e7. doi:10.1016/j.chom.2017.04.005Google ScholarDOIPubMed
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Early Epstein-Barr Virus Genomic Diversity and Convergence toward the B95.8 Genome in Primary Infection.
Weiss ER, Lamers SL, Henderson JL, et al. Early Epstein-Barr Virus Genomic Diversity and Convergence toward the B95.8 Genome in Primary Infection. J Virol. 2018;92(2). doi:10.1128/JVI.01466-17Google ScholarDOIPubMed
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CRISPR-Cas9 Genetic Analysis of Virus-Host Interactions.
Gebre M, Nomburg JL, Gewurz BE. CRISPR-Cas9 Genetic Analysis of Virus-Host Interactions. Viruses. 2018;10(2). doi:10.3390/v10020055Google ScholarDOIPubMed
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Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.
Choy E, Yelensky R, Bonakdar S, et al. Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines. PLoS Genet. 2008;4(11):e1000287. doi:10.1371/journal.pgen.1000287Google ScholarDOIPubMed
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IFN-alpha-stimulated genes and Epstein-Barr virus gene expression distinguish WHO type II and III nasopharyngeal carcinomas.
Pegtel M, Subramanian A, Meritt D, et al. IFN-alpha-stimulated genes and Epstein-Barr virus gene expression distinguish WHO type II and III nasopharyngeal carcinomas. Cancer Res. 2007;67(2):474-81. doi:10.1158/0008-5472.CAN-06-1882Google ScholarDOIPubMed
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Epstein-Barr-virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasis.
Pegtel DM, Subramanian A, Sheen TS, Tsai CH, Golub TR, Thorley-Lawson DA. Epstein-Barr-virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasis. J Virol. 2005;79(24):15430-42. doi:10.1128/JVI.79.24.15430-15442.2005Google ScholarDOIPubMed
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Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance.
Kang MS, Lee EK, Soni V, et al. Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance. J Virol. 2011;85(6):2859-68. doi:10.1128/JVI.01628-10Google ScholarDOIPubMed
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The tumor virus landscape of AIDS-related lymphomas.
Arvey A, Ojesina AI, Pedamallu CS, et al. The tumor virus landscape of AIDS-related lymphomas. Blood. 2015;125(20):e14-22. doi:10.1182/blood-2014-11-599951PubMedDOIGoogle Scholar
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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