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Reconstruction of single-cell lineage trajectories and identification of diversity in fates during the epithelial-to-mesenchymal transition.
Cheng YC, Zhang Y, Tripathi S, et al. Reconstruction of single-cell lineage trajectories and identification of diversity in fates during the epithelial-to-mesenchymal transition. Proceedings of the National Academy of Sciences of the United States of America. 2024;121(32):e2406842121. doi:10.1073/pnas.2406842121DOIGoogle ScholarPubMed
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Primary nasal influenza infection rewires tissue-scale memory response dynamics.
Kazer SW, Match CM, Langan EM, et al. Primary nasal influenza infection rewires tissue-scale memory response dynamics. Immunity. 2024. doi:10.1016/j.immuni.2024.06.005DOIGoogle ScholarPubMed
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Cellular dynamics in pig-to-human kidney xenotransplantation.
Pan W, Zhang W, Zheng B, et al. Cellular dynamics in pig-to-human kidney xenotransplantation. Med (New York, N.Y.). 2024. doi:10.1016/j.medj.2024.05.003DOIGoogle ScholarPubMed
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Single-cell RNA sequencing data imputation using bi-level feature propagation.
Lee J, Yun S, Kim Y, Chen T, Kellis M, Park C. Single-cell RNA sequencing data imputation using bi-level feature propagation. Briefings in bioinformatics. 2024;25(3). doi:10.1093/bib/bbae209DOIGoogle ScholarPubMed
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An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection.
Ziegler CGK, Owings AH, Galeas-Pena M, et al. An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection. Microbiology spectrum. 2024:e0351623. doi:10.1128/spectrum.03516-23DOIGoogle ScholarPubMed
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Single cell multi-omics of fibrotic kidney reveal epigenetic regulation of antioxidation and apoptosis within proximal tubule.
Chen Z, Ye L, Zhu M, et al. Single cell multi-omics of fibrotic kidney reveal epigenetic regulation of antioxidation and apoptosis within proximal tubule. Cellular and molecular life sciences : CMLS. 2024;81(1):56. doi:10.1007/s00018-024-05118-1DOIGoogle ScholarPubMed
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Positional influence on cellular transcriptional identity revealed through spatially segmented single-cell transcriptomics.
Morse DB, Michalowski AM, Ceribelli M, et al. Positional influence on cellular transcriptional identity revealed through spatially segmented single-cell transcriptomics. Cell systems. 2023;14(6):464-481.e7. doi:10.1016/j.cels.2023.05.003DOIGoogle ScholarPubMed
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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