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Contemporary Prognostic Signatures and Refined Risk Stratification of Gliomas: An Analysis of 4,400 Tumors.
Ghosh HS, Patel R V, Woodward E, et al. Contemporary Prognostic Signatures and Refined Risk Stratification of Gliomas: An Analysis of 4,400 Tumors. Neuro-oncology. 2024. doi:10.1093/neuonc/noae164PubMedDOIGoogle Scholar
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Contemporary Prognostic Signatures and Refined Risk Stratification of Gliomas: An Analysis of 4,400 Tumors.
Ghosh HS, Patel R V, Woodward E, et al. Contemporary Prognostic Signatures and Refined Risk Stratification of Gliomas: An Analysis of 4,400 Tumors. Neuro-oncology. 2024. doi:10.1093/neuonc/noae164Google ScholarPubMedDOI
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Genome-wide Polygenic Risk Scores Predict Risk of Glioma and Molecular Subtypes.
Nakase T, Guerra GA, Ostrom QT, et al. Genome-wide Polygenic Risk Scores Predict Risk of Glioma and Molecular Subtypes. Neuro-oncology. 2024. doi:10.1093/neuonc/noae112PubMedDOIGoogle Scholar
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Genome-wide Polygenic Risk Scores Predict Risk of Glioma and Molecular Subtypes.
Nakase T, Guerra GA, Ostrom QT, et al. Genome-wide Polygenic Risk Scores Predict Risk of Glioma and Molecular Subtypes. Neuro-oncology. 2024. doi:10.1093/neuonc/noae112Google ScholarPubMedDOI
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Integrative spatial analysis reveals a multi-layered organization of glioblastoma.
Greenwald AC, Darnell NG, Hoefflin R, et al. Integrative spatial analysis reveals a multi-layered organization of glioblastoma. Cell. 2024. doi:10.1016/j.cell.2024.03.029PubMedDOIGoogle Scholar
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Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma.
Spitzer A, Gritsch S, Nomura M, et al. Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma. Cancer cell. 2024. doi:10.1016/j.ccell.2024.03.008PubMedDOIGoogle Scholar
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Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes.
Ganz J, Luquette LJ, Bizzotto S, et al. Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes. Cell. 2024. doi:10.1016/j.cell.2024.02.025PubMedDOIGoogle Scholar
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Genome-wide Polygenic Risk Scores Predict Risk of Glioma and Molecular Subtypes.
Nakase T, Guerra G, Ostrom QT, et al. Genome-wide Polygenic Risk Scores Predict Risk of Glioma and Molecular Subtypes. medRxiv : the preprint server for health sciences. 2024. doi:10.1101/2024.01.10.24301112PubMedDOIGoogle Scholar
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An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma.
Casillo SM, Gatesman TA, Chilukuri A, et al. An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma. Cell reports. 2023;43(1):113557. doi:10.1016/j.celrep.2023.113557PubMedDOIGoogle Scholar
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Temporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma.
Drexler R, Khatri R, Schüller U, et al. Temporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma. Acta neuropathologica. 2024;147(1):21. doi:10.1007/s00401-023-02677-8PubMedGoogle ScholarDOI
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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