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Functional genomics of human skeletal development and the patterning of height heritability.
Richard D, Muthuirulan P, Young M, et al. Functional genomics of human skeletal development and the patterning of height heritability. Cell. 2024. doi:10.1016/j.cell.2024.10.040PubMedDOIGoogle Scholar
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Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma.
Zarif TE, Semaan K, Eid M, et al. Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma. Cell reports. 2024;43(6):114350. doi:10.1016/j.celrep.2024.114350Google ScholarPubMedDOI
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Single-cell multi-scale footprinting reveals the modular organization of DNA regulatory elements.
Hu Y, Ma S, Kartha VK, et al. Single-cell multi-scale footprinting reveals the modular organization of DNA regulatory elements. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.28.533945Google ScholarPubMedDOI
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Single-cell multi-scale footprinting reveals the modular organization of DNA regulatory elements.
Hu Y, Ma S, Kartha VK, et al. Single-cell multi-scale footprinting reveals the modular organization of DNA regulatory elements. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.28.533945PubMedDOIGoogle Scholar
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Cardiovascular Disease Knowledge Portal: A Community Resource for Cardiovascular Disease Research.
Costanzo MC, Roselli C, Brandes M, et al. Cardiovascular Disease Knowledge Portal: A Community Resource for Cardiovascular Disease Research. Circulation. Genomic and precision medicine. 2023:e004181. doi:10.1161/CIRCGEN.123.004181Google ScholarPubMedDOI
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Genetic and Epigenetic Determinants of Aggressiveness in Cribriform Carcinoma of the Prostate.
Elfandy H, Armenia J, Pederzoli F, et al. Genetic and Epigenetic Determinants of Aggressiveness in Cribriform Carcinoma of the Prostate. Mol Cancer Res. 2019;17(2):446-456. doi:10.1158/1541-7786.MCR-18-0440PubMedDOIGoogle Scholar
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Epigenetics and Epigenomics: Implications for Diabetes and Obesity.
Rosen ED, Kaestner KH, Natarajan R, et al. Epigenetics and Epigenomics: Implications for Diabetes and Obesity. Diabetes. 2018;67(10):1923-1931. doi:10.2337/db18-0537PubMedDOIGoogle Scholar
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diffloop: a computational framework for identifying and analyzing differential DNA loops from sequencing data.
Lareau CA, Aryee MJ. diffloop: a computational framework for identifying and analyzing differential DNA loops from sequencing data. Bioinformatics. 2018;34(4):672-674. doi:10.1093/bioinformatics/btx623Google ScholarPubMedDOI
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What is the epigenome and is it involved in multiple sclerosis?
Lee JY, De Jager PL. What is the epigenome and is it involved in multiple sclerosis?. Mult Scler. 2018;24(3):268-269. doi:10.1177/1352458517750769PubMedDOIGoogle Scholar
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Advancing drug discovery for schizophrenia.
Marder SR, Roth B, Sullivan PF, et al. Advancing drug discovery for schizophrenia. Ann N Y Acad Sci. 2011;1236:30-43. doi:10.1111/j.1749-6632.2011.06216.xPubMedDOIGoogle Scholar
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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