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Experimental Evolution Identifies Adaptive Aneuploidy as a Mechanism of Fluconazole Resistance in Candida auris.
Bing J, Hu T, Zheng Q, Muñoz JF, Cuomo CA, Huang G. Experimental Evolution Identifies Adaptive Aneuploidy as a Mechanism of Fluconazole Resistance in Candida auris. Antimicrob Agents Chemother. 2020;65(1). doi:10.1128/AAC.01466-20DOIPubMedGoogle Scholar
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Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.
Youngsaye W, Dockendorff C, Vincent B, et al. Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles. Bioorg Med Chem Lett. 2012;22(9):3362-5. doi:10.1016/j.bmcl.2012.02.035DOIPubMedGoogle Scholar
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Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. grubii and C. gattii.
Chen Y, Farrer RA, Giamberardino C, et al. Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. grubii and C. gattii. MBio. 2017;8(2). doi:10.1128/mBio.00166-17DOIPubMedGoogle Scholar
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Genetic Analysis of Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance.
Kim SH, Iyer KR, Pardeshi L, et al. Genetic Analysis of Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance. MBio. 2019;10(1). doi:10.1128/mBio.02529-18DOIPubMedGoogle Scholar
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Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy.
McLellan CA, Vincent BM, Solis NV, et al. Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy. Nat Chem Biol. 2018;14(2):135-141. doi:10.1038/nchembio.2534DOIPubMedGoogle Scholar
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Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris.
Rybak JM, Muñoz JF, Barker KS, et al. Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris. mBio. 2020;11(3). doi:10.1128/mBio.00365-20DOIPubMedGoogle Scholar
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MARDy: Mycology Antifungal Resistance Database.
Nash A, Sewell T, Farrer RA, et al. MARDy: Mycology Antifungal Resistance Database. Bioinformatics. 2018;34(18):3233-3234. doi:10.1093/bioinformatics/bty321DOIPubMedGoogle Scholar
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The evolution of drug resistance in clinical isolates of Candida albicans.
Ford CB, Funt JM, Abbey D, et al. The evolution of drug resistance in clinical isolates of Candida albicans. Elife. 2015;4:e00662. doi:10.7554/eLife.00662DOIPubMedGoogle Scholar
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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