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Technical variability across the 450K, EPICv1, and EPICv2 DNA methylation arrays: lessons learned for clinical and longitudinal studies.
Lussier AA, Schuurmans IK, Großbach A, et al. Technical variability across the 450K, EPICv1, and EPICv2 DNA methylation arrays: lessons learned for clinical and longitudinal studies. Clinical epigenetics. 2024;16(1):166. doi:10.1186/s13148-024-01761-4DOIGoogle ScholarPubMed
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Methylation Mesa define functional regulatory elements for targeted gene activation.
Liu Y V, Suryatenggara J, Wong H, et al. Methylation Mesa define functional regulatory elements for targeted gene activation. Research square. 2024. doi:10.21203/rs.3.rs-4359582/v1DOIGoogle ScholarPubMed
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Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts.
Wani AH, Katrinli S, Zhao X, et al. Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts. BMC medical genomics. 2024;17(1):235. doi:10.1186/s12920-024-02002-6DOIGoogle ScholarPubMed
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Subcellular one carbon metabolism in cancer, aging and epigenetics.
Bernasocchi T, Mostoslavsky R. Subcellular one carbon metabolism in cancer, aging and epigenetics. Frontiers in epigenetics and epigenomics. 2024;2. doi:10.3389/freae.2024.1451971DOIGoogle ScholarPubMed
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Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohorts.
Katrinli S, Wani AH, Maihofer AX, et al. Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohorts. medRxiv : the preprint server for health sciences. 2024. doi:10.1101/2024.07.15.24310422DOIGoogle ScholarPubMed
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Pathogenic variants in KMT2C result in a neurodevelopmental disorder distinct from Kleefstra and Kabuki syndromes.
Rots D, Choufani S, Faundes V, et al. Pathogenic variants in KMT2C result in a neurodevelopmental disorder distinct from Kleefstra and Kabuki syndromes. American journal of human genetics. 2024. doi:10.1016/j.ajhg.2024.06.009DOIGoogle ScholarPubMed
Read more
Pathogenic variants in KMT2C result in a neurodevelopmental disorder distinct from Kleefstra and Kabuki syndromes.
Rots D, Choufani S, Faundes V, et al. Pathogenic variants in KMT2C result in a neurodevelopmental disorder distinct from Kleefstra and Kabuki syndromes. American journal of human genetics. 2024. doi:10.1016/j.ajhg.2024.06.009DOIGoogle ScholarPubMed
Read more
Pathogenic variants in KMT2C result in a neurodevelopmental disorder distinct from Kleefstra and Kabuki syndromes.
Rots D, Choufani S, Faundes V, et al. Pathogenic variants in KMT2C result in a neurodevelopmental disorder distinct from Kleefstra and Kabuki syndromes. American journal of human genetics. 2024. doi:10.1016/j.ajhg.2024.06.009DOIGoogle ScholarPubMed
Read more
Pathogenic variants in KMT2C result in a neurodevelopmental disorder distinct from Kleefstra and Kabuki syndromes.
Rots D, Choufani S, Faundes V, et al. Pathogenic variants in KMT2C result in a neurodevelopmental disorder distinct from Kleefstra and Kabuki syndromes. American journal of human genetics. 2024. doi:10.1016/j.ajhg.2024.06.009DOIGoogle ScholarPubMed
Read more
Maximizing Insights from Longitudinal Epigenetic Age Data: Simulations, Applications, and Practical Guidance.
Großbach A, Suderman MJ, Hüls A, et al. Maximizing Insights from Longitudinal Epigenetic Age Data: Simulations, Applications, and Practical Guidance. Research square. 2024. doi:10.21203/rs.3.rs-4482915/v1DOIGoogle ScholarPubMed
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

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In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

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Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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