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Nucleic acid detection with CRISPR-Cas13a/C2c2.
Gootenberg JS, Abudayyeh OO, Lee JW, et al. Nucleic acid detection with CRISPR-Cas13a/C2c2. Science. 2017;356(6336):438-442. doi:10.1126/science.aam9321DOIGoogle ScholarPubMed
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Field-deployable viral diagnostics using CRISPR-Cas13.
Myhrvold C, Freije CA, Gootenberg JS, et al. Field-deployable viral diagnostics using CRISPR-Cas13. Science. 2018;360(6387):444-448. doi:10.1126/science.aas8836DOIGoogle ScholarPubMed
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Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity.
OhAinle M, Balmaseda A, Macalalad AR, et al. Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity. Sci Transl Med. 2011;3(114):114ra128. doi:10.1126/scitranslmed.3003084DOIGoogle ScholarPubMed
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High-resolution analysis of intrahost genetic diversity in dengue virus serotype 1 infection identifies mixed infections.
Thai KTD, Henn MR, Zody MC, et al. High-resolution analysis of intrahost genetic diversity in dengue virus serotype 1 infection identifies mixed infections. J Virol. 2012;86(2):835-43. doi:10.1128/JVI.05985-11DOIGoogle ScholarPubMed
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A phylogenetic analysis using full-length viral genomes of South American dengue serotype 3 in consecutive Venezuelan outbreaks reveals a novel NS5 mutation.
Schmidt DJ, Pickett BE, Camacho D, et al. A phylogenetic analysis using full-length viral genomes of South American dengue serotype 3 in consecutive Venezuelan outbreaks reveals a novel NS5 mutation. Infect Genet Evol. 2011;11(8):2011-9. doi:10.1016/j.meegid.2011.09.010DOIGoogle ScholarPubMed
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Genetic diversity and lineage dynamic of dengue virus serotype 1 (DENV-1) in Cambodia.
Duong V, Simmons C, Gavotte L, et al. Genetic diversity and lineage dynamic of dengue virus serotype 1 (DENV-1) in Cambodia. Infect Genet Evol. 2013;15:59-68. doi:10.1016/j.meegid.2011.06.019DOIGoogle ScholarPubMed
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Endemic dengue associated with the co-circulation of multiple viral lineages and localized density-dependent transmission.
Raghwani J, Rambaut A, Holmes EC, et al. Endemic dengue associated with the co-circulation of multiple viral lineages and localized density-dependent transmission. PLoS Pathog. 2011;7(6):e1002064. doi:10.1371/journal.ppat.1002064DOIGoogle ScholarPubMed
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Endurance, refuge, and reemergence of dengue virus type 2, Puerto Rico, 1986-2007.
McElroy KL, Santiago GA, Lennon NJ, Birren BW, Henn MR, Muñoz-Jordán JL. Endurance, refuge, and reemergence of dengue virus type 2, Puerto Rico, 1986-2007. Emerg Infect Dis. 2011;17(1):64-71. doi:10.3201/eid1701.100961DOIGoogle ScholarPubMed
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Emergence of the Asian 1 genotype of dengue virus serotype 2 in viet nam: in vivo fitness advantage and lineage replacement in South-East Asia.
Vu TTH, Holmes EC, Duong V, et al. Emergence of the Asian 1 genotype of dengue virus serotype 2 in viet nam: in vivo fitness advantage and lineage replacement in South-East Asia. PLoS Negl Trop Dis. 2010;4(7):e757. doi:10.1371/journal.pntd.0000757DOIGoogle ScholarPubMed
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Index cluster study of dengue virus infection in Nicaragua.
Reyes M, Mercado JC, Standish K, et al. Index cluster study of dengue virus infection in Nicaragua. Am J Trop Med Hyg. 2010;83(3):683-9. doi:10.4269/ajtmh.2010.10-0023DOIGoogle ScholarPubMed
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

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Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

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