Conserved Sequence | Broad Institute

MACF1 Mutations Encoding Highly Conserved Zinc-Binding Residues of the GAR Domain Cause Defects in Neuronal Migration and Axon Guidance.

Dobyns WB, Aldinger KA, Ishak GE, et al. MACF1 Mutations Encoding Highly Conserved Zinc-Binding Residues of the GAR Domain Cause Defects in Neuronal Migration and Axon Guidance. Am J Hum Genet. 2018;103(6):1009-1021. doi:10.1016/j.ajhg.2018.10.019PubMed Google Scholar DOI

Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition.

DeRan M, Pulvino M, Greene E, Su C, Zhao J. Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition. Mol Cell Biol. 2008;28(1):435-47. doi:10.1128/MCB.00607-07PubMed Google Scholar DOI

Whole-genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom.

Chheda H, Palta P, Pirinen M, et al. Whole-genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom. Eur J Hum Genet. 2017;25(4):477-484. doi:10.1038/ejhg.2016.205PubMed Google Scholar DOI

Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals.

Washietl S, Kellis M, Garber M. Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals. Genome Res. 2014;24(4):616-28. doi:10.1101/gr.165035.113PubMed Google Scholar DOI

Conserved loci of leaf and stem rust fungi of wheat share synteny interrupted by lineage-specific influx of repeat elements.

Fellers JP, Soltani BM, Bruce M, et al. Conserved loci of leaf and stem rust fungi of wheat share synteny interrupted by lineage-specific influx of repeat elements. BMC Genomics. 2013;14:60. doi:10.1186/1471-2164-14-60PubMed Google Scholar DOI

A putative Vibrio cholerae two-component system controls a conserved periplasmic protein in response to the antimicrobial peptide polymyxin B.

Matson JS, Livny J, DiRita VJ. A putative Vibrio cholerae two-component system controls a conserved periplasmic protein in response to the antimicrobial peptide polymyxin B. PLoS One. 2017;12(10):e0186199. doi:10.1371/journal.pone.0186199Google Scholar PubMed DOI

A mechanism for a single nucleotide intron shift.

Fekete E, Flipphi M, Ág N, et al. A mechanism for a single nucleotide intron shift. Nucleic Acids Res. 2017;45(15):9085-9092. doi:10.1093/nar/gkx520Google Scholar PubMed DOI

A highly conserved cysteine of neuronal calcium-sensing proteins controls cooperative binding of Ca2+ to recoverin.

Ranaghan MJ, Kumar RP, Chakrabarti KS, Buosi V, Kern D, Oprian DD. A highly conserved cysteine of neuronal calcium-sensing proteins controls cooperative binding of Ca2+ to recoverin. J Biol Chem. 2013;288(50):36160-7. doi:10.1074/jbc.M113.524355Google Scholar PubMed DOI

Lso2 is a conserved ribosome-bound protein required for translational recovery in yeast.

Wang YJ, Vaidyanathan PP, Rojas-Duran MF, et al. Lso2 is a conserved ribosome-bound protein required for translational recovery in yeast. PLoS Biol. 2018;16(9):e2005903. doi:10.1371/journal.pbio.2005903Google Scholar PubMed DOI

Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder.

An JY, Lin K, Zhu L, et al. Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder. Science. 2018;362(6420). doi:10.1126/science.aat6576Google Scholar PubMed DOI