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Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays.
Haggarty SJ, Koeller KM, Wong JC, Butcher RA, Schreiber SL. Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays. Chem Biol. 2003;10(5):383-96.Google ScholarPubMed
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From knowing to controlling: a path from genomics to drugs using small molecule probes.
Strausberg RL, Schreiber SL. From knowing to controlling: a path from genomics to drugs using small molecule probes. Science. 2003;300(5617):294-5. doi:10.1126/science.1083395DOIGoogle ScholarPubMed
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Pathway development and pilot library realization in diversity-oriented synthesis: exploring Ferrier and Pauson-Khand reactions on a glycal template.
Kubota H, Lim J, Depew KM, Schreiber SL. Pathway development and pilot library realization in diversity-oriented synthesis: exploring Ferrier and Pauson-Khand reactions on a glycal template. Chem Biol. 2002;9(2):265-76.Google ScholarPubMed
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A one-bead, one-stock solution approach to chemical genetics: part 1.
Blackwell HE, Pérez L, Stavenger RA, et al. A one-bead, one-stock solution approach to chemical genetics: part 1. Chem Biol. 2001;8(12):1167-82.Google ScholarPubMed
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Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts.
Zhong C, Wang Y, Hung AW, Schreiber SL, Young DW. Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts. Org Lett. 2011;13(20):5556-9. doi:10.1021/ol202276hDOIGoogle ScholarPubMed
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Ligand design by a combinatorial approach based on modeling and experiment: application to HLA-DR4.
Evensen E, Joseph-McCarthy D, Weiss GA, Schreiber SL, Karplus M. Ligand design by a combinatorial approach based on modeling and experiment: application to HLA-DR4. J Comput Aided Mol Des. 2007;21(7):395-418. doi:10.1007/s10822-007-9119-xDOIGoogle ScholarPubMed
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The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core.
Zhou G, Ferrer M, Chopra R, et al. The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core. Bioorg Med Chem. 2000;8(9):2219-27.Google ScholarPubMed
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Synthesis and cellular profiling of diverse organosilicon small molecules.
Franz AK, Dreyfuss PD, Schreiber SL. Synthesis and cellular profiling of diverse organosilicon small molecules. J Am Chem Soc. 2007;129(5):1020-1. doi:10.1021/ja067552nDOIGoogle ScholarPubMed
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Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements.
Ferrer M, Kapoor TM, Strassmaier T, et al. Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements. Nat Struct Biol. 1999;6(10):953-60. doi:10.1038/13324DOIGoogle ScholarPubMed
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Small-molecule diversity using a skeletal transformation strategy.
Kumar N, Kiuchi M, Tallarico JA, Schreiber SL. Small-molecule diversity using a skeletal transformation strategy. Org Lett. 2005;7(13):2535-8. doi:10.1021/ol0504345DOIGoogle ScholarPubMed
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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