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"Monitoring inflammatory, immune system mediators, and mitochondrial changes related to brain metabolism during space flight".
Tocci D, Ducai T, Stoute CAB, et al. "Monitoring inflammatory, immune system mediators, and mitochondrial changes related to brain metabolism during space flight". Frontiers in immunology. 2024;15:1422864. doi:10.3389/fimmu.2024.1422864PubMedDOIGoogle Scholar
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Stress molecular signaling in interaction with cognition.
Lugenbühl JF, Viho EMG, Binder EB, Daskalakis NP. Stress molecular signaling in interaction with cognition. Biological psychiatry. 2024. doi:10.1016/j.biopsych.2024.09.023PubMedDOIGoogle Scholar
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Inhibition of GSK3α,β rescues cognitive phenotypes in a preclinical mouse model of CTNNB1 syndrome.
Alexander JM, Vazquez-Ramirez L, Lin C, et al. Inhibition of GSK3α,β rescues cognitive phenotypes in a preclinical mouse model of CTNNB1 syndrome. EMBO molecular medicine. 2024. doi:10.1038/s44321-024-00110-5PubMedDOIGoogle Scholar
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Inhibition of GSK3α,β rescues cognitive phenotypes in a preclinical mouse model of CTNNB1 syndrome.
Alexander JM, Vazquez-Ramirez L, Lin C, et al. Inhibition of GSK3α,β rescues cognitive phenotypes in a preclinical mouse model of CTNNB1 syndrome. EMBO molecular medicine. 2024. doi:10.1038/s44321-024-00110-5PubMedDOIGoogle Scholar
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Delineating cognitive resilience using fractal regulation: Cross-sectional and longitudinal evidence from the Rush Memory and Aging Project.
Li P, Gao C, Yu L, et al. Delineating cognitive resilience using fractal regulation: Cross-sectional and longitudinal evidence from the Rush Memory and Aging Project. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2024. doi:10.1002/alz.13747PubMedDOIGoogle Scholar
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Polygenic burden and its association with baseline cognitive function and postoperative cognitive outcome in temporal lobe epilepsy.
Arrotta K, Ferguson L, Thompson N, et al. Polygenic burden and its association with baseline cognitive function and postoperative cognitive outcome in temporal lobe epilepsy. Epilepsy & behavior : E&B. 2024;153:109692. doi:10.1016/j.yebeh.2024.109692PubMedDOIGoogle Scholar
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Associations of brain morphology with cortical proteins of cognitive resilience.
Poole VN, Ridwan AR, Arfanakis K, et al. Associations of brain morphology with cortical proteins of cognitive resilience. Neurobiology of aging. 2024;137:1-7. doi:10.1016/j.neurobiolaging.2024.02.005PubMedDOIGoogle Scholar
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TWINGEN - protocol for an observational clinical biobank recall and biomarker study to identify individuals with high risk of Alzheimer's disease.
Vuoksimaa E, Saari TT, Aaltonen A, et al. TWINGEN - protocol for an observational clinical biobank recall and biomarker study to identify individuals with high risk of Alzheimer’s disease. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.11.03.23298018PubMedDOIGoogle Scholar
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The Shared Genetic Basis of Educational Attainment and Cerebral Cortical Morphology.
Ge T, Chen CY, Doyle AE, et al. The Shared Genetic Basis of Educational Attainment and Cerebral Cortical Morphology. Cereb Cortex. 2019;29(8):3471-3481. doi:10.1093/cercor/bhy216PubMedDOIGoogle Scholar
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A Polygenic Score for Higher Educational Attainment is Associated with Larger Brains.
Elliott ML, Belsky DW, Anderson K, et al. A Polygenic Score for Higher Educational Attainment is Associated with Larger Brains. Cereb Cortex. 2019;29(8):3496-3504. doi:10.1093/cercor/bhy219PubMedDOIGoogle Scholar
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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