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Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction.
Koblan LW, Doman JL, Wilson C, et al. Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction. Nat Biotechnol. 2018;36(9):843-846. doi:10.1038/nbt.4172PubMedDOIGoogle Scholar
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Overproduction of proteins using expression-cassette polymerase chain reaction.
MacFerrin KD, Chen L, Terranova MP, Schreiber SL, Verdine GL. Overproduction of proteins using expression-cassette polymerase chain reaction. Methods Enzymol. 1993;217:79-102.PubMedGoogle Scholar
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Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis.
Ma L, Huang DW, Cuomo CA, et al. Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis. FASEB J. 2013;27(5):1962-72. doi:10.1096/fj.12-224444PubMedDOIGoogle Scholar
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Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules.
Usanov DL, Chan AI, Maianti JP, Liu DR. Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules. Nat Chem. 2018;10(7):704-714. doi:10.1038/s41557-018-0033-8Google ScholarPubMedDOI
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Evolution of genes and genomes on the Drosophila phylogeny.
Drosophila 12 Genomes Consortium, Clark AG, Eisen MB, et al. Evolution of genes and genomes on the Drosophila phylogeny. Nature. 2007;450(7167):203-18. doi:10.1038/nature06341PubMedDOIGoogle Scholar
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Revisiting the protein-coding gene catalog of Drosophila melanogaster using 12 fly genomes.
Lin MF, Carlson JW, Crosby MA, et al. Revisiting the protein-coding gene catalog of Drosophila melanogaster using 12 fly genomes. Genome Res. 2007;17(12):1823-36. doi:10.1101/gr.6679507PubMedDOIGoogle Scholar
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Positive selection for unpreferred codon usage in eukaryotic genomes.
Neafsey DE, Galagan JE. Positive selection for unpreferred codon usage in eukaryotic genomes. BMC Evol Biol. 2007;7:119. doi:10.1186/1471-2148-7-119PubMedDOIGoogle Scholar
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Dual modes of natural selection on upstream open reading frames.
Neafsey DE, Galagan JE. Dual modes of natural selection on upstream open reading frames. Mol Biol Evol. 2007;24(8):1744-51. doi:10.1093/molbev/msm093PubMedDOIGoogle Scholar
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Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae.
Kellis M, Birren BW, Lander ES. Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae. Nature. 2004;428(6983):617-24. doi:10.1038/nature02424PubMedDOIGoogle Scholar
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Estimating selection on synonymous codon usage from noisy experimental data.
Wallace EWJ, Airoldi EM, Drummond A. Estimating selection on synonymous codon usage from noisy experimental data. Mol Biol Evol. 2013;30(6):1438-53. doi:10.1093/molbev/mst051PubMedDOIGoogle Scholar
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

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Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

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