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Helicobacter pylori expresses an autolytic enzyme: gene identification, cloning, and theoretical protein structure.
Marsich E, Zuccato P, Rizzi S, Vetere A, Tonin E, Paoletti S. Helicobacter pylori expresses an autolytic enzyme: gene identification, cloning, and theoretical protein structure. J Bacteriol. 2002;184(22):6270-9.Google ScholarPubMed
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Comparative genomic and transcriptomic analysis of wangiella dermatitidis, a major cause of phaeohyphomycosis and a model black yeast human pathogen.
Chen Z, Martinez DA, Gujja S, et al. Comparative genomic and transcriptomic analysis of wangiella dermatitidis, a major cause of phaeohyphomycosis and a model black yeast human pathogen. G3 (Bethesda). 2014;4(4):561-78. doi:10.1534/g3.113.009241PubMedDOIGoogle Scholar
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Coordinated host-pathogen transcriptional dynamics revealed using sorted subpopulations and single macrophages infected with Candida albicans.
Muñoz JF, Delorey T, Ford CB, et al. Coordinated host-pathogen transcriptional dynamics revealed using sorted subpopulations and single macrophages infected with Candida albicans. Nat Commun. 2019;10(1):1607. doi:10.1038/s41467-019-09599-8Google ScholarPubMedDOI
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The Expanding Diversity of Mycobacterium tuberculosis Drug Targets.
Wellington S, Hung DT. The Expanding Diversity of Mycobacterium tuberculosis Drug Targets. ACS Infect Dis. 2018;4(5):696-714. doi:10.1021/acsinfecdis.7b00255PubMedDOIGoogle Scholar
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Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.
Stanley SA, Grant SS, Kawate T, et al. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem Biol. 2012;7(8):1377-84. doi:10.1021/cb300151mPubMedDOIGoogle Scholar
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Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.
Ma L, Chen Z, Huang DW, et al. Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts. Nat Commun. 2016;7:10740. doi:10.1038/ncomms10740PubMedDOIGoogle Scholar
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Populations of latent Mycobacterium tuberculosis lack a cell wall: Isolation, visualization, and whole-genome characterization.
Velayati AA, Abeel T, Shea T, et al. Populations of latent Mycobacterium tuberculosis lack a cell wall: Isolation, visualization, and whole-genome characterization. Int J Mycobacteriol. 2016;5(1):66-73. doi:10.1016/j.ijmyco.2015.12.001PubMedDOIGoogle Scholar
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Comparative genomics of enterococci: variation in Enterococcus faecalis, clade structure in E. faecium, and defining characteristics of E. gallinarum and E. casseliflavus.
Palmer KL, Godfrey P, Griggs A, et al. Comparative genomics of enterococci: variation in Enterococcus faecalis, clade structure in E. faecium, and defining characteristics of E. gallinarum and E. casseliflavus. MBio. 2012;3(1):e00318-11. doi:10.1128/mBio.00318-11PubMedGoogle ScholarDOI
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Whole genome characterization of the mechanisms of daptomycin resistance in clinical and laboratory derived isolates of Staphylococcus aureus.
Peleg AY, Miyakis S, Ward DV, et al. Whole genome characterization of the mechanisms of daptomycin resistance in clinical and laboratory derived isolates of Staphylococcus aureus. PLoS One. 2012;7(1):e28316. doi:10.1371/journal.pone.0028316PubMedGoogle ScholarDOI
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An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode.
Larsen NA, Nash TJ, Morningstar M, et al. An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode. Biochem J. 2012;446(3):405-13. doi:10.1042/BJ20120596PubMedDOIGoogle Scholar
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research.

In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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