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An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection.
Ziegler CGK, Owings AH, Galeas-Pena M, et al. An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection. Microbiology spectrum. 2024:e0351623. doi:10.1128/spectrum.03516-23DOIPubMedGoogle Scholar
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Genome-Wide Analysis of Experimentally Evolved Candida auris Reveals Multiple Novel Mechanisms of Multidrug Resistance.
Carolus H, Pierson S, Muñoz JF, et al. Genome-Wide Analysis of Experimentally Evolved Candida auris Reveals Multiple Novel Mechanisms of Multidrug Resistance. mBio. 2021;12(2). doi:10.1128/mBio.03333-20DOIPubMedGoogle Scholar
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Clade-specific chromosomal rearrangements and loss of subtelomeric adhesins in Candida auris.
Muñoz JF, Welsh RM, Shea T, et al. Clade-specific chromosomal rearrangements and loss of subtelomeric adhesins in Candida auris. Genetics. 2021;218(1). doi:10.1093/genetics/iyab029DOIPubMedGoogle Scholar
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An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris.
Iyer KR, Camara K, Daniel-Ivad M, et al. An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nat Commun. 2020;11(1):6429. doi:10.1038/s41467-020-20183-3DOIPubMedGoogle Scholar
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Experimental Evolution Identifies Adaptive Aneuploidy as a Mechanism of Fluconazole Resistance in Candida auris.
Bing J, Hu T, Zheng Q, Muñoz JF, Cuomo CA, Huang G. Experimental Evolution Identifies Adaptive Aneuploidy as a Mechanism of Fluconazole Resistance in Candida auris. Antimicrob Agents Chemother. 2020;65(1). doi:10.1128/AAC.01466-20DOIPubMedGoogle Scholar
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Identification of Inhibitors of Fungal Fatty Acid Biosynthesis.
DeJarnette C, Meyer CJ, Jenner AR, et al. Identification of Inhibitors of Fungal Fatty Acid Biosynthesis. ACS Infect Dis. 2021;7(12):3210-3223. doi:10.1021/acsinfecdis.1c00404DOIPubMedGoogle Scholar
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Whole Genome Sequence of the Heterozygous Clinical Isolate 81-B-5.
Cuomo CA, Shea T, Yang B, Rao R, Forche A. Whole Genome Sequence of the Heterozygous Clinical Isolate 81-B-5. G3 (Bethesda). 2017;7(9):2883-2889. doi:10.1534/g3.117.043547DOIPubMedGoogle Scholar
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Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris.
Rhodes J, Abdolrasouli A, Farrer RA, et al. Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris. Emerg Microbes Infect. 2018;7(1):43. doi:10.1038/s41426-018-0045-xDOIPubMedGoogle Scholar
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Genetic Analysis of Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance.
Kim SH, Iyer KR, Pardeshi L, et al. Genetic Analysis of Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance. MBio. 2019;10(1). doi:10.1128/mBio.02529-18DOIPubMedGoogle Scholar
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Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species.
Muñoz JF, Gade L, Chow NA, et al. Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species. Nat Commun. 2018;9(1):5346. doi:10.1038/s41467-018-07779-6DOIPubMedGoogle Scholar
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

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