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Per- and poly-fluoroalkyl substances (PFAS) accelerate biological aging mediated by increased C-reactive protein.
Zhao Z, Zhou J, Shi A, et al. Per- and poly-fluoroalkyl substances (PFAS) accelerate biological aging mediated by increased C-reactive protein. Journal of hazardous materials. 2024;480:136090. doi:10.1016/j.jhazmat.2024.136090DOIPubMedGoogle Scholar
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Per- and poly-fluoroalkyl substances (PFAS) accelerate biological aging mediated by increased C-reactive protein.
Zhao Z, Zhou J, Shi A, et al. Per- and poly-fluoroalkyl substances (PFAS) accelerate biological aging mediated by increased C-reactive protein. Journal of hazardous materials. 2024;480:136090. doi:10.1016/j.jhazmat.2024.136090DOIPubMedGoogle Scholar
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Genetic Predisposition to Elevated C-reactive Protein and Risk of Obstructive Sleep Apnea.
Huang T, Goodman M, Wang H, et al. Genetic Predisposition to Elevated C-reactive Protein and Risk of Obstructive Sleep Apnea. American journal of respiratory and critical care medicine. 2023. doi:10.1164/rccm.202307-1159LEDOIPubMedGoogle Scholar
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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
Ligthart S, Vaez A, Võsa U, et al. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. Am J Hum Genet. 2018;103(5):691-706. doi:10.1016/j.ajhg.2018.09.009DOIPubMedGoogle Scholar
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An interaction map of circulating metabolites, immune gene networks, and their genetic regulation.
Nath AP, Ritchie SC, Byars SG, et al. An interaction map of circulating metabolites, immune gene networks, and their genetic regulation. Genome Biol. 2017;18(1):146. doi:10.1186/s13059-017-1279-yDOIPubMedGoogle Scholar
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Genome-wide association study of bronchopulmonary dysplasia: a potential role for variants near the CRP gene.
Mahlman M, Karjalainen MK, Huusko JM, et al. Genome-wide association study of bronchopulmonary dysplasia: a potential role for variants near the CRP gene. Sci Rep. 2017;7(1):9271. doi:10.1038/s41598-017-08977-wDOIPubMedGoogle Scholar
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Posttraumatic stress disorder onset and inflammatory and endothelial function biomarkers in women.
Sumner JA, Chen Q, Roberts AL, et al. Posttraumatic stress disorder onset and inflammatory and endothelial function biomarkers in women. Brain Behav Immun. 2018;69:203-209. doi:10.1016/j.bbi.2017.11.013DOIPubMedGoogle Scholar
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Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-aged Adults in the Framingham Study.
Weinstein G, Zelber-Sagi S, Preis SR, et al. Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-aged Adults in the Framingham Study. JAMA Neurol. 2018;75(1):97-104. doi:10.1001/jamaneurol.2017.3229DOIPubMedGoogle Scholar
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Allelic Heterogeneity at the CRP Locus Identified by Whole-Genome Sequencing in Multi-ancestry Cohorts.
Raffield LM, Iyengar AK, Wang B, et al. Allelic Heterogeneity at the CRP Locus Identified by Whole-Genome Sequencing in Multi-ancestry Cohorts. Am J Hum Genet. 2020;106(1):112-120. doi:10.1016/j.ajhg.2019.12.002DOIPubMedGoogle Scholar
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Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community.
Schnabel RB, Yin X, Larson MG, et al. Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community. Arterioscler Thromb Vasc Biol. 2013;33(7):1728-33. doi:10.1161/ATVBAHA.112.301174DOIPubMedGoogle Scholar
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

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In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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