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Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening.
Gentili M, Carlson RJ, Liu B, et al. Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening. Cell systems. 2024. doi:10.1016/j.cels.2024.11.004DOIPubMedGoogle Scholar
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Soluble Human Lectins at the Host-Microbe Interface.
Peiffer AL, Dugan AE, Kiessling LL. Soluble Human Lectins at the Host-Microbe Interface. Annual review of biochemistry. 2024;93(1):565-601. doi:10.1146/annurev-biochem-062917-012322DOIGoogle ScholarPubMed
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SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses.
Chiu HP, Yeo YY, Lai TY, et al. SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.09.05.611469DOIGoogle ScholarPubMed
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SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses.
Chiu HP, Yeo YY, Lai TY, et al. SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.09.05.611469DOIGoogle ScholarPubMed
Read more
SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses.
Chiu HP, Yeo YY, Lai TY, et al. SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.09.05.611469DOIGoogle ScholarPubMed
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An essential role for Cmtr2 in mammalian embryonic development.
Yermalovich A V, Mohsenin Z, Cowdin M, et al. An essential role for Cmtr2 in mammalian embryonic development. Developmental biology. 2024. doi:10.1016/j.ydbio.2024.07.019DOIGoogle ScholarPubMed
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Host innate immune systems gather intel on invading microbes via pathogen-derived extracellular vesicles.
Kwaku GN, Ward RA, Vyas JM, Harding HB. Host innate immune systems gather intel on invading microbes via pathogen-derived extracellular vesicles. Extracellular vesicle. 2024;3. doi:10.1016/j.vesic.2024.100043DOIGoogle ScholarPubMed
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Correction of age-associated defects in dendritic cells enables CD4 T cells to eradicate tumors.
Zhivaki D, Kennedy SN, Park J, et al. Correction of age-associated defects in dendritic cells enables CD4 T cells to eradicate tumors. Cell. 2024. doi:10.1016/j.cell.2024.05.026DOIGoogle ScholarPubMed
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Integrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality.
Gygi JP, Maguire C, Patel RK, et al. Integrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality. The Journal of clinical investigation. 2024;134(9). doi:10.1172/JCI176640DOIGoogle ScholarPubMed
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Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine.
Senkpeil L, Bhardwaj J, Little MR, et al. Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine. JCI insight. 2024. doi:10.1172/jci.insight.167408DOIGoogle ScholarPubMed
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In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Broad Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

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Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

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In November 2022, Broad’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Broad’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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