This two-day symposium, chaired by Steve Hyman, Guoping Feng and Ben Neale, will bring together leading scientists working on the genetics, neurobiology, and treatment of schizophrenia, bipolar disorder, autism spectrum disorder, and related neuropsychiatric disorders.
The central theme this year will address the challenges of turning genetic results that reveal extreme polygenicity into useful biological insights that can help patients. Graduate students and postdoctoral associates are especially welcomed to this symposium in order to build this interdisciplinary field and address the unmet medical needs of patients and their families at a time of great opportunity and urgency.
Agenda
Day 1
| Monday, September 16, 2019 | |
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Session 1: Genetics: Setting the Problem, revealing the challenge Chair: Ben Neale |
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| 8:50 – 9:00 |
Welcome Steve Hyman, Broad Institute |
| 9:00 – 9:10 |
Session Introduction Ben Neale, Massachusetts General Hospital/Broad Institute |
| 9:10 – 9:40 | Stephan Ripke, Charité University/Massachusetts General Hospital |
| 9:40 – 10:10 | Hilary Finucane, Broad Institute |
| 10:10 – 10:40 | Sarah Medland, QMIR Berghofer |
| 10:40 – 11:00 | Coffee Break |
| 11:00 – 11:30 | Kathryn Roeder, Carnegie Mellon University |
| 11:30 – 12:00 | Elise Robinson, Harvard T.H. Chan School of Public Health/Broad Institute |
| 12:00 – 12:45 |
Panel Discussion: How do we put the genetics to work Randy Buckner, Alicia Martin, Ken Kendler, Kevin Eggan, Anji Addington |
| 12:45 – 1:15 | Lunch |
| Short talks selected from submitted abstracts | |
| 1:15 – 1:20 |
Intro to short talks Guoping Feng, MIT/Broad Institute |
| 1:20 – 1:35 | Short Talk I |
| 1:35 – 1:50 | Short Talk II |
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Session 2: Clinical Translation: phenotyping and patient stratification Chair: TBC |
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| 1:50 – 2:00 |
Session Introduction Chair |
| 2:00 – 2:30 | Carrie Bearden, UCLA |
| 2:30 – 3:00 | Henrik Zetterberg, University of Gothenburg |
| 3:00 – 3:20 | Coffee Break |
| 3:20 – 3:50 | Eric Minikel & Sonia Vallabh, Broad Institute |
| 3:50 – 4:20 | Sally John, Biogen |
| 4:20 – 4:50 | Flo Wagner, Broad Institute & Beth Stevens, Boston Children’s Hospital/Broad Institute |
| 4:50 – 5:00 | Closing remarks from session chair |
| Poster Session & Reception | |
| 5:15 – 7:00 | McGovern Institute Atrium |
Day 2
| Tuesday, September 17, 2019 | |
| 8:15 – 8:50 | Breakfast in Lobby |
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Session 3: Enabling Technologies Chair: Evan Macosko |
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| 8:50 – 9:00 |
Session Introduction Evan Macosko, Harvard Medical School/Broad Institute |
| 9:00 – 9:30 | Ed Callaway, Salk Institute |
| 9:30 – 10:00 | Xiaowei Zhuang, Harvard University |
| 10:00 – 10:20 | Coffee Break |
| 10:20 – 10:50 | Karl Deisseroth, Stanford University |
| 10:50 – 11:20 | Kristin Branson, Janelia Research Campus |
| 11:20 – 11:50 | 3 Teaser talks for poster session #2 |
| 11:50 – 1:00 | Lunch and poster session round 2 |
| Keynote | |
| 1:00 – 1:05 |
Keynote Introduction Steve Hyman |
| 1:05 – 2:00 |
Keynote Marcus Raichle Washington University in St Louis |
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Session 4: Biology enabled by new models Chair: Paola Arlotta |
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| 2:00 – 2:10 |
Session Introduction Paola Arlotta, Harvard University/Broad Institute |
| 2:10 – 2:50 | Grae Davis, UCSF |
| 2:50 – 3:20 | Bart de Strooper, VIB-KU Leuven |
| 3:20 – 3:40 | Lindy Barrett, Broad Institute |
| 3:40 – 4:00 | Coffee Break |
| 4:00 – 4:30 | Ed Lein, Allen Institute |
| 4:30 – 4:50 | Fenna Krienen, Broad Institute |
| 4:50 – 5:20 | Panel Discussion: How do we get to quantitative biology; the role of the model organism |
| 5:20 – 5:30 | Concluding remarks from symposium chairs |
