Severe Mental Illness: From Polygenicity to Biology

This two-day symposium, chaired by Steve Hyman, Guoping Feng and Ben Neale, will bring together leading scientists working on the genetics, neurobiology, and treatment of schizophrenia, bipolar disorder, autism spectrum disorder, and related neuropsychiatric disorders.

The central theme this year will address the challenges of turning genetic results that reveal extreme polygenicity into useful biological insights that can help patients. Graduate students and postdoctoral associates are especially welcomed to this symposium in order to build this interdisciplinary field and address the unmet medical needs of patients and their families at a time of great opportunity and urgency.

All sessions will be held in the auditorium of the Broad Institute, 415 Main Street, Cambridge MA 02142.

 

Agenda

Day 1

Monday, September 16, 2019

Chair: Ben Neale
8:15 – 8:50
8:50 – 9:00
Broad Institute
9:00 – 9:10
Session Introduction
Massachusetts General Hospital/Broad Institute
9:10 – 9:40
Common genetic variants associated with Schizophrenia: a Psychiatric Genomics Consortium (PGC) collaboration
Charité University/Massachusetts General Hospital
9:40 – 10:10
Leveraging polygenicity for biological insight from genome-wide association data
Broad Institute
10:10 – 10:40
ENIGMA at 10: What have we learned from a decade of large scale collaborative meta-analysis in neuroimaging
QIMR Berghofer
10:40 – 11:00
11:00 – 11:30
Adaptively using auxiliary data to discover risk genes provides powerful insights into mental illnesses
Carnegie Mellon University
11:30 – 12:00
Interpreting genetic associations with detailed human behavioral data
Harvard T.H. Chan School of Public Health/Broad Institute
12:45 – 1:15
1:15 – 1:20
Intro to short talks
MIT/Broad Institute
1:20 – 1:35
Short Talk I
Harvard University/Stanley Center for Psychiatric Research
1:35 – 1:50
Short Talk II
Boston Children’s Hospital/Harvard Medical School
Chair: Morgan Sheng
1:50 – 2:00
Session Introduction
Broad Institute
2:00 – 2:30
Clinical utility of polygenic risk for prediction in high risk populations
UCLA
2:30 – 3:00
Using fluid biomarkers to investigate brain disorders
University of Gothenburg
3:00 – 3:20
3:20 – 3:50
Primary prevention of brain disease
Broad Institute
3:50 – 4:20
Patient selection strategies for clinical trails in monogenic and complex neurological disease
Biogen
4:20 – 4:50
Designing Imaging Biomarkers for Microglia States
Broad Institute
&
Boston Children’s Hospital/Broad Institute
5:15 – 7:00
McGovern Institute Atrium

 

 

Day 2

Tuesday, September 17, 2019

Chair: Evan Macosko
8:15 – 8:50
8:50 – 9:00
Session Introduction
Harvard Medical School/Broad Institute
9:00 – 9:30
Dissecting Neural Circuits Across Model Systems with Cell Type and Single Cell Resolution
Salk Institute
9:30 – 10:00
Single-cell transcriptome imaging and cell atlas of brain tissues
Harvard University
10:00 – 10:20
10:20 – 10:50
The circuit dynamics of brain states
Stanford University
10:50 – 11:20
Analyzing animal behavior using machine vision and learning
Janelia Research Campus
11:20 – 11:30
3 Teaser talks for poster session #2
Massachusetts General Hospital
Stanley Center for Psychiatric Research on behalf of the SCHEMA consortium
11:30 – 11:40
Stanford University
University of Massachusetts Amherst
11:40 – 11:50
Sunovion Pharmaceuticals Inc.
1:00 – 1:05
Keynote Introduction
1:05 – 2:00
Chair: Paola Arlotta
2:00 – 2:10
Session Introduction
Harvard University/Broad Institute
2:10 – 2:50
Coupling Genotype to Phenotype: Genetic Buffering, Homeostatic Plasticity and a Phenotypic Spectrum
UCSF
2:50 – 3:20
Translating genetic risk of Alzheimer’s disease into mechanisms of disease
VIB-KU Leuven
3:20 – 3:40
Dissecting mechanisms of FMRP in RNA processing using human stem cell models
Broad Institute
3:40 – 4:00
4:00 – 4:20
Innovations in Primate Interneuron Repertoire
Broad Institute
4:20 – 4:50
Conservation and divergence of human brain cell types
Allen Institute
5:20 – 5:30
Concluding remarks from symposium chairs