Severe Mental Illness: From Polygenicity to Biology

This two-day symposium, chaired by Steve Hyman, Guoping Feng and Ben Neale, will bring together leading scientists working on the genetics, neurobiology, and treatment of schizophrenia, bipolar disorder, autism spectrum disorder, and related neuropsychiatric disorders.

The central theme this year will address the challenges of turning genetic results that reveal extreme polygenicity into useful biological insights that can help patients. Graduate students and postdoctoral associates are especially welcomed to this symposium in order to build this interdisciplinary field and address the unmet medical needs of patients and their families at a time of great opportunity and urgency.

 

Agenda

Day 1

Monday, September 16, 2019
Session 1: Genetics: Setting the Problem, revealing the challenge
Chair: Ben Neale
8:50 – 9:00 Welcome
Steve Hyman, Broad Institute
9:00 – 9:10 Session Introduction
Ben Neale, Massachusetts General Hospital/Broad Institute
9:10 – 9:40 Stephan Ripke, Charité University/Massachusetts General Hospital
9:40 – 10:10 Hilary Finucane, Broad Institute
10:10 – 10:40 Sarah Medland, QMIR Berghofer
10:40 – 11:00 Coffee Break
11:00 – 11:30 Kathryn Roeder, Carnegie Mellon University
11:30 – 12:00 Elise Robinson, Harvard T.H. Chan School of Public Health/Broad Institute
12:00 – 12:45 Panel Discussion: How do we put the genetics to work
Randy Buckner, Alicia Martin, Ken Kendler, Kevin Eggan, Anji Addington
12:45 – 1:15 Lunch
Short talks selected from submitted abstracts
1:15 – 1:20 Intro to short talks
Guoping Feng, MIT/Broad Institute
1:20 – 1:35 Short Talk I
1:35 – 1:50 Short Talk II
Session 2: Clinical Translation: phenotyping and patient stratification
Chair: TBC
1:50 – 2:00 Session Introduction
Chair
2:00 – 2:30 Carrie Bearden, UCLA
2:30 – 3:00 Henrik Zetterberg, University of Gothenburg
3:00 – 3:20 Coffee Break
3:20 – 3:50 Eric Minikel & Sonia Vallabh, Broad Institute
3:50 – 4:20 Sally John, Biogen
4:20 – 4:50 Flo Wagner, Broad Institute & Beth Stevens, Boston Children’s Hospital/Broad Institute
4:50 – 5:00 Closing remarks from session chair
Poster Session & Reception
5:15 – 7:00 McGovern Institute Atrium

 

 

Day 2

Tuesday, September 17, 2019
8:15 – 8:50 Breakfast in Lobby
Session 3: Enabling Technologies
Chair: Evan Macosko
8:50 – 9:00 Session Introduction
Evan Macosko, Harvard Medical School/Broad Institute
9:00 – 9:30 Ed Callaway, Salk Institute
9:30 – 10:00 Xiaowei Zhuang, Harvard University
10:00 – 10:20 Coffee Break
10:20 – 10:50 Karl Deisseroth, Stanford University
10:50 – 11:20 Kristin Branson, Janelia Research Campus
11:20 – 11:50 3 Teaser talks for poster session #2
11:50 – 1:00 Lunch and poster session round 2
Keynote
1:00 – 1:05 Keynote Introduction
Steve Hyman
1:05 – 2:00 Keynote
Marcus Raichle
Washington University in St Louis
Session 4: Biology enabled by new models
Chair: Paola Arlotta
2:00 – 2:10 Session Introduction
Paola Arlotta, Harvard University/Broad Institute
2:10 – 2:50 Grae Davis, UCSF
2:50 – 3:20 Bart de Strooper, VIB-KU Leuven 
3:20 – 3:40 Lindy Barrett, Broad Institute
3:40 – 4:00 Coffee Break
4:00 – 4:30 Ed Lein, Allen Institute
4:30 – 4:50 Fenna Krienen, Broad Institute
4:50 – 5:20 Panel Discussion: How do we get to quantitative biology; the role of the model organism
5:20 – 5:30 Concluding remarks from symposium chairs