This two-day symposium, chaired by Dr. Steve Hyman, Director of the Stanley Center for Psychiatric Research at Broad Institute, Dr. Guoping Feng of McGovern Institute at MIT and Director of the Neurobiology and Model Systems group of the Stanley Center, and Dr. Benjamin Neale of Massachusetts General Hospital and Director of Population Genetics at the Stanley Center, brought together leading scientists working on the genetics and neurobiology of schizophrenia, bipolar disorder, autism spectrum disorder and related neuropsychiatric disorders, with scientists working on translating genetic findings to models and mechanisms that will pave the way to effective therapeutics for these diseases.
Agenda
Day 1
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Session 1: Recent Advances in Genetics Chair: Mark Daly |
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| 9:00 – 9:10 |
Welcome and Introduction Steve Hyman, Broad Institute |
| 9:10 – 9:40 | Ben Neale, Harvard Medical School |
| 9:40 – 10:10 | Mick O’Donovan, Cardiff |
| 10:10 – 10:40 | Tarjinder Singh, Broad Institute |
| 10:40 – 11:00 | Coffee Break |
| 11:00 – 11:30 | Lea Davis, Vanderbilt |
| 11:30 – 12:00 | David Goldstein, Columbia |
| Short talks selected from submitted abstracts | |
| 12:00 – 12:15 | Short Talk I: Pim van Nierop, Vrije Universiteit, Amsterdam on behalf of the SynGO Consortium |
| 12:15– 12:30 | Short Talk II: Anthone Koleske, Yale University |
| 12:30 – 1:30 | Lunch |
| Session 2: The Challenge of Modeling Brain Disorders | |
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2A. 2D and 3D cellular models Chair: Evan Macosko |
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| 1:30 – 2:00 | Paola Arlotta, Harvard |
| 2:00 – 2:30 | Sally Temple, Neural Stem Cell Institute |
| 2:30 – 3:00 | Guo-Li Ming, Johns Hopkins |
| 3:00 – 3:30 | Sergiu Pasca, Stanford |
| 3:30 – 4:00 | Coffee Break |
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2B. Non-human primates and human experimental biology Chair: Guoping Feng |
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| 4:00 – 4:30 | Alvaro Pascual-Leone, Harvard Medical School |
| 4:30 – 4:45 | Rogier Landman, Broad Institute |
| 4:45 – 5:00 | Reona Kobayashi, Keio University |
| 5:00 – 5:30 | Randy Buckner, Harvard |
| Poster session and reception | |
| 6:00 – 8:00 | McGovern Institute Atrium |
Day 2
| Session 3: From genetics to mechanisms | |
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3A. Synapses Chair: Steve McCarroll |
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| 9:00 – 9:45 |
Keynote Talk Roger Nicoll, UCSF |
| 9:45 – 10:15 | Beth Stevens, Harvard Medical School |
| 10:15 – 10:30 | Coffee Break |
| 10:30 – 11:00 | David Lewis, University of Pittsburgh |
| 11:00 – 11:30 | Amy Arnsten, Yale |
| Short talks selected from submitted abstracts | |
| 11:30 – 11:45 | Short talk III: Jana Mitchell, Harvard University/Stanley Center for Psychiatric Research |
| 11:45 – 12:00 | Short talk IV: Dima Ter-Ovanesyan, Harvard University/Broad Institute |
| 12:00 – 1:00 | Lunch |
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3B. Circuits Chair: Bob Desimone |
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| 1:00 – 1:30 | Russell Foster, Oxford |
| 1:30 – 2:00 | Zhanyan Fu, Broad Institute |
| 2:00 – 2:30 | Mike Halassa, NYU |
| 2:30 – 3:00 | Coffee Break |
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4. Biomarkers and Therapeutics Chair: Jeff Cottrell |
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| 3:00 – 3:45 | Morgan Sheng, Genentech |
| 3:45 – 4:15 | Jacob Hooker, Massachusetts General Hospital |
| 4:15 – 4:45 | Mark Bear, MIT |
| 4:45 – 5:00 | Coffee Break |
| 5:00 – 5:45 |
Panel discussion
Steve Hyman, Harvard |
| 5:45 – 6:00 | Closing remarks |
