Severe Mental Illness: From Genes to Models to Mechanism

This two-day symposium, chaired by Dr. Steve Hyman, Director of the Stanley Center for Psychiatric Research at Broad Institute, Dr. Guoping Feng of McGovern Institute at MIT and Director of the Neurobiology and Model Systems group of the Stanley Center, and Dr. Benjamin Neale of Massachusetts General Hospital and Director of Population Genetics at the Stanley Center, brought together leading scientists working on the genetics and neurobiology of schizophrenia, bipolar disorder, autism spectrum disorder and related neuropsychiatric disorders, with scientists working on translating genetic findings to models and mechanisms that will pave the way to effective therapeutics for these diseases.

Agenda

Day 1

Monday, September 25, 2017

Session 1: Recent Advances in Genetics Chair: Mark Daly
9:00 – 9:10	Welcome and Introduction Steve Hyman, Broad Institute
9:10 – 9:40	Ben Neale, Harvard Medical School
9:40 – 10:10	Mick O’Donovan, Cardiff
10:10 – 10:40	Tarjinder Singh, Broad Institute
10:40 – 11:00	Coffee Break
11:00 – 11:30	Lea Davis, Vanderbilt
11:30 – 12:00	David Goldstein, Columbia
Short talks selected from submitted abstracts
12:00 – 12:15	Short Talk I: Pim van Nierop, Vrije Universiteit, Amsterdam on behalf of the SynGO Consortium
12:15– 12:30	Short Talk II: Anthone Koleske, Yale University
12:30 – 1:30	Lunch
Session 2: The Challenge of Modeling Brain Disorders
2A. 2D and 3D cellular models Chair: Evan Macosko
1:30 – 2:00	Paola Arlotta, Harvard
2:00 – 2:30	Sally Temple, Neural Stem Cell Institute
2:30 – 3:00	Guo-Li Ming, Johns Hopkins
3:00 – 3:30	Sergiu Pasca, Stanford
3:30 – 4:00	Coffee Break
2B. Non-human primates and human experimental biology Chair: Guoping Feng
4:00 – 4:30	Alvaro Pascual-Leone, Harvard Medical School
4:30 – 4:45	Rogier Landman, Broad Institute
4:45 – 5:00	Reona Kobayashi, Keio University
5:00 – 5:30	Randy Buckner, Harvard
Poster session and reception
6:00 – 8:00	McGovern Institute Atrium

Day 2

Tuesday, September 26, 2017

Session 3: From genetics to mechanisms
3A. Synapses Chair: Steve McCarroll
9:00 – 9:45	Keynote Talk Roger Nicoll, UCSF
9:45 – 10:15	Beth Stevens, Harvard Medical School
10:15 – 10:30	Coffee Break
10:30 – 11:00	David Lewis, University of Pittsburgh
11:00 – 11:30	Amy Arnsten, Yale
Short talks selected from submitted abstracts
11:30 – 11:45	Short talk III: Jana Mitchell, Harvard University/Stanley Center for Psychiatric Research
11:45 – 12:00	Short talk IV: Dima Ter-Ovanesyan, Harvard University/Broad Institute
12:00 – 1:00	Lunch
3B. Circuits Chair: Bob Desimone
1:00 – 1:30	Russell Foster, Oxford
1:30 – 2:00	Zhanyan Fu, Broad Institute
2:00 – 2:30	Mike Halassa, NYU
2:30 – 3:00	Coffee Break
4. Biomarkers and Therapeutics Chair: Jeff Cottrell
3:00 – 3:45	Morgan Sheng, Genentech
3:45 – 4:15	Jacob Hooker, Massachusetts General Hospital
4:15 – 4:45	Mark Bear, MIT
4:45 – 5:00	Coffee Break

5:00 – 5:45	Panel discussion Steve Hyman, Harvard Bob Desimone, MIT Mark Daly, MGH/HMS Flo Wagner, Broad Institute Linda Brady, NIMH I-han Chou, Nature John Spiro, Simons Foundation
5:45 – 6:00	Closing remarks