# Aligned 3'UTR sequences of REST in the order of human, mouse, rat, dog and opossum. # Predicted miRNA targeting sites are annotated on top of the alignment with miRNA seeds indicated. # Only miRNAs with seeds perfectly conserved in human,mouse,rat and dog are shown. # Only miRNAs with seeds prefectly conserved in all mammals including opossum are reported in the paper. # >REST.utr3 CTCAAGGGCAGGAGTAA----------------------------TGAAA CTGAGGAGCAGGAGGAGCAGGAGGAGCGGGAGGAGCAGGAGTAGCTGAGC CTGAGGAGCAGGAGTAG----------------------AGTAGCTGATC CTAAAGGGCAGGAGTAA----------------------------TTAAT CTAAGGAGTTAGAATAA----------------------------CTAAA ** * * * ** * * 50 C----TTTGAACAAGGTTTCAGTTCTTAGTTTGTAAGGTATATTACATTT C----TCGGCAGAAG--CACCGTGCAGACTTTGTGAG--------CATGC C----TCAGGAGAAG--CACAATGCGGACTTTGTAAG----CATGCCTCT C----TTAGGATAAGGCTTCAGTTCTTAGTTTATGCGATCTATTACATTT CTCTATTTGAATAAGCCTACAATTCT---TTCATCAGATCTCTTCTGTTT * * * * *** * * * ** * * * 100 TATATTCATTTATGATAGCAGACAACC-------TTTTAAGATTGCTTTA AATTTTAATTT------GTAGACAAAC---------GCAAGCTTGCTTTA AATTTTAGTTT--GACTGTAGACAAAT---------GTAAG-TTGCTTTG AATATTCATTTATAGCTGTAGACAACCTTTTGTTTTTTTAAATTGCTTTA TGTGGATAATTATTATATTAGACACCT-------TTTTTTCA--GTTCGG * ** ***** * * 150 ATTAGTATCTGATGTTGATTTTTAAGTGGCATTCTTTTCCTTAGGACTTT ATTAGTCTCCAAGGCTGAGTTTTCAGTAACATTCTTTTTCTTAGGACTGT GTCAGTCTCCAGTGCTG--TCTTCAGTAACATTCTTTTTCTTAT------ ATTAGTGTCCAATGTTGATTTTTAAGTGGCACTCTTTTCCTTAGGACTCT ACTAGTATCTGA---TGATTTGGGGTAGATACTTTTTTCTTCA--ACCTT *** ** ** * * * **** * * 200 TTATGTATACCTGTTGATTGTTGTGTAAATTT---------TAGTAAATC ACATCTAT--TTAGTGTTTGTTGCATAAATCT---------TAGCAAATC ----------TTAGTGGTTGTTGGATAAATCT---------TAGCAAATT GTATATCT--------ATTGATGGATAAATTT---------TAGCAAATC GTATG--------------ATAGTTTAAAACTTGCTACAACTAGTGAATC * **** * *** *** 250 TAAGAG----AGTG-------------TACTAAACCAGCA---------- CTCGGGAGTTAATG-------------TAAGAG---GACA---------- CTAGAGAGTTGGTG-------------TAAGGA---GACA---------- CAAGGAAGTTAGTG-------------TACTAAACCAGCA---------- CAAGGA----ATCGTTTTTCTCTTTTCTACTCATCTAGCACTAGTGAAAG * * ** ** 300 ---GGTATCT------GT----TAGCTTATGTGTTTAATTGAAATTAGAA ---GATATGTA-----AC----TAGCTCGTGCAGGCAGGTGCAAGGAGAA ---GATACCTA-----AC----CAAATCATGCAGTCGGGTGCAAGGAGAA ---GATACCTAAATCTGT----TAGTTTATACATTTAATTGAAATGAGAA ACTAGTAGCC------TTTGCATAAATTATTTTTAAAGTAAGATTTAGAA ** * * * * **** 350 GGCTAAGATGGTATAACAGCATTTTATTGCTTTGTCCAGCTACAACTTGT GGGTAAGATGGTGGAACA-CACCAC-TTGCCTTGTCTGCCTACAACCTGT GGGTAAGATGGTGGAACA--------CGCCCTTGTCTGCCTACAA----- GGCCAAGGTGGTATTGTAGCATTCTGTTGCTTTGTCTGGCTGTAACTTGT AACTAAGATTATACACAAACGTTCTATTGA-TCATACAGTTATTAGCAGT *** * * * * * * * 400 CATTTTTTTCTCCATGTCTTATCTTCCTGTTTCACTTTAGTTT---ATTC TGGGTTTTCT-------------------TTTCACGGTAGTTCCTAATTT -GTGTTTTCTGTCAGGTTTTCTGTTCT--TTTCACTGTAGTTCCTAATTT CACTTTTCTTGCCATGTC-TGTCTTCTTGTTTCGCTTTAGTTT---TTTC AGTTCATTTTCTCATTTCTAGTC-TCTAGTTTTA-------TG---GTTC * *** * ** 450 TTCGTTTTTTATTGAGATCTATAAAAAATTGGCTTACTT-AATAGCAAAT TTAGTTACTTGTTTAGATCGAT-AAAAATTGGCT--------TAGTAAAT TTAGTT-CTTGTTTAGATTGAT-AAAAATTGGCT--------TAGTAAAT TTAGTTCTTTGTTTAGTTCTAT-AAAAATTGGCATACTTAAATAGCAAAT CTTGTTTAGTTAGGAGG-----GATAAATCAGCATA-TT-AGTAGCAAAT * *** * ** * **** ** *** **** 500 TAC-------------TTGAAGAATTTGCC-TGCTTTATATA----AAGT TAC-------------TTGAAGAATTTGCC-TGCTTTATATAAATTAAGT TAC-------------TTGAAGAATTTGCC-TGCTTTATATAAAT-AAGT TAC-------------TT---GAATTTGCC-TGCTTTATATA----AAGT TACTCAATGGTTTTCTTTGAGGAATCTGATGTGTCTTTCAGA----CAAT *** ** **** ** ** ** * * * * 550 AGCACTT (miR-93,miR-302a,miR-302b,miR-302c,miR-302d,miR-372,miR-373,miR-520e,miR-520a,miR-526b*,miR-520b,miR-520c,miR-520d) human/mouse/rat/dog/opossum GCACTTT (miR-17-5p,miR-20a,miR-106a,miR-106b,miR-20b,miR-519d) human/mouse/rat/dog/opossum TAGCACTTT-----AAGAT-------TTTTTTTTTTAGAGATG----AGA TAGCACTTT-----ACAG-----------TTTCTTTAGAGATGAAAAAAA TAGCACTTT-----ACAG-----------TTTCTTTAGAGATG----AAA TAGCACTTT-----AAAA-----------TTTTTTTAGAGATG--AGAAG TAGCACTTTTAACAAAAACAGCCACAATGCGGCTGAAAAAATG----AAC ********* * * * * *** * 600 AGACATTTAAATTGAAGAAA-------AATTCCCCCAGCAATAGACAGTC AGAGATTTTAATTGGAGAGA-------AATT--CTCAACATTGGACATTG AAGGATTTAAATTGGAGAGA-------AATT--TCCTACATTGGACATTG AGACATTTAAATTGAAGAAA-------AATTCTCCCAACAGTGGACATTG AGTCAT---AATTTTAAAAATGTTTTTGTTTCTCCCTATAATGGACAGTG * ** **** * * * ** * * * **** * 650 TA-TCAGTCCA--------AGTATTTACTTCCTGAGTTTTGATCAATATT TA-TCTGTCCA--------GGTAATTGCTTCCTAACTTGCTATCAATATT TA-TCTGTCCA--------GATAATGGCTTCCTAACTTGCTATCAATATT TA-TCAGTCCA--------GGTATTTACTTACTGAGTTTTGATCAATATT AATTTCGTCCACATTTATTAGTCTTTTTTCTTT---TTTTAATTAAAATT * * ***** * * * * ** ** ** *** 700 TTTTATTTGTGTATGTTAATCGTCATAAA--------AACAGTGATTTT- TTGTGTT--TATATGTTAATCGTTATAAA--------A--AGTGATTTT- CTGTGTT--TATATGTTAATCATTATAAA--------A--AGTGATTTT- TCTTATTTGTGTATGTTAATCGTCATAAA--------AACAATGATTTT- TCTGATTTGTATATGTCAATCTTCATAAAAATATTATAACAATGGTTTTT ** * ***** **** * ***** * * ** **** 750 ------------------GGT-------GTG------------------- ------------------TGTTTTTTGGGTA------------------- ------------------TG--------GTA------------------- ------------------GGT-------GTG---ttttttttttctttca AATTGTGGGAAGTAAAGGGGA-------GTGTTC---------------- * ** 800 TGGTGCT (miR-29a,miR-29b,miR-29c) human/mouse/rat/dog/opossum -------------TTTTTTATTT----TGGTGCTTTAATGGCTTAAGATG -------------TTTTTTATTT----TGGTGCTTTTCTGGCTTAAGATG -------------TTTTTTACTT----TGGTGCTTTTCTGGCTTAAGATG agttttttttttttttttttttt----tGGTGCTTTAATGGCTTAAGATG -------------TTTTTTATTTTTGGTGGTGCTTTAATGGCTTAAAATG ****** ** ********* ******** *** 850 CTATGCA (miR-153) human/mouse/rat/dog/opossum ATGCAGT (miR-217) human/mouse/rat/dog/opossum TTGCACATTTTTTTTTTCTTTTGGTTTCTGTTTATGTTTTTTT-GCCTAT TTGCACA--------------TGGTTCTTGTTTTTGTTTCTTTAACCTAT TTGCACA--------------TGGTTCTTGTTTTTGTTTCTTTAACCTAT TTGCACA-TTG--------------TTTTGTTT---TTTTTTTAACCTAT TTGCACATTGTGTTTTTGATT-------------TTTTTTTTT-ACCTAT ******* *** *** ***** 900 GCAGTTAAATT---TTTCCTAGAAATAGCA-TTTGTGTTGAACAGTAACA GCAGTTAATCTCCCTTCCCCTGAAACAGCG--TTGTGTTAAATAGTAACA GCAGTTAATCTCCCTTCCCCAGAAACAGCA--TTGTGTTAAATAGTAACA GCAGTTCAATT--TTTTTCTAGAAATAGTA-TTCGTGTTGAACAGTAACA GCAGTGTAATC---TTT--TAGAAATAGCATTTTTTGCtgtacaggaaca ***** * ** **** ** * ** * * ** **** 950 CTTTATA--------------------------------CATATATATAT CTATACA--------------------------------GATATATGCAT CTAGACA--------------------------------TATATATGCAT CTTTATA--------------------------------CATATAT--AT ctttatatatatatgtgtgtgtgtgtatatatatatctgcatatatatat ** * * ****** ** 1000 GCATGTTTATTTTGTTTG----------------GCGTCTTTGGAGGGAT GGTTTTTTTTTTTGTTTGTTTGTTTGTTTGTTTTTCCTTTTTGGAGGGAT GGTTTTTGTTTTT---------------------CCCTTTTTGGAGGGAT GCATGTTTATTTTG--------------------TCCTCTTTCGAGGGAT gcgtgtttatTTTGATTG----------------A----TTTAAAAAAA- * * ** **** *** * * 1050 GCTTTTAGACTTGT---TTGCAAAAGGGCA---------GTTTTCTTTTT GCTTTTAGGCTTGT---TTGC-AAAGGGCC---------ATTTTCCTTTT GCTTTTAGGCTTGT---TTGC-AAAGGGCC---------ATTTTCCTTTT GCTTTTAGTCTTGT---TTGCAAAAGGGCA---------GTTTTCTTTTT -CTTTCAGGTTTGTTGCTTACCACAGAGCAGGTGTTTTCGTGTTCATTTC **** ** **** ** * * ** ** * *** *** 1100 -CTTTGCTGCAGTT-------------------GTCT----ATTTTGCAG -CTTTGCTGCAGTT-------------------GTCT----TTTTTGCAG -CTTTGCTGCAATT-------------------GTCT----TTTTTGCAG CCTTTGCTGCAATT-------------------GTCT----TTTTTGCAG -CTTTGCTGCAGTTTAATCTTTTTTCATGGGGAGTCTTTTGAGTTTGCTA ********** ** **** ***** 1150 AA---------TAATAGT--GTGTGCAAG-------------TTTGTGAG AA---------CAATAGT--GTGTGAAAG-------------TTTATAAG AA---------CAATAGTGCGTGTGCAAG-------------TTTATAAA AA---------TATTAGT--GTGTGCAAA-------------TTTGTGAG AAATTAAGAATTATTTGT--GTGTATATGTGCTAATGTATCATTTGTGAG ** * * ** **** * *** * * 1200 CAAATGAA--ATATGCAGGTTC-AATCTATTG-ATTTTG----------- C-AATGGA--ACATGCAGGTTC-AATCCATTG-TTTTGGGTTTTGTTTTG C-AATGGA--ACATGCAGGTTC-AATCCATTG-TTTTGGGTTTTGTTTTA CAAATGAA--ACATGCAGGTTC-AATCCATTG-ATTTTG----------- CAGATGAAGCAAATGCAGATTCAAATCCATTATATTTTG----------- * *** * * ****** *** **** *** *** * 1250 ----ATTTTTACATCTTA-------------TATCTATGCCAGAATCTGT TTTTATTTTTTTATTTTA-AATTTCACCACTTATCTATGCCAGAATTAG- TT--ATTTTTTTATTTTAAA-TTTCACCTCTTACCTATGCCAGGATTAG- ----AATTTCACATCTTA-------------TATCTATGCCAGAATCTGT ----ATTTTTACATCTGA-------------TGCATAT--TAGAATCTGT * *** ** * * * *** ** ** * 1300 ATTTCATA-TAACTTATTTATTTCGAATGG-------ATGTAGTAAATTC -TTTCATA-TA----AGTTATTTTGAATGGTGAGGATATGT-GTAATTCC -TTTCATA-TA----AGTTATTTTGAATGGTGAAGAAATGT-GTAATTCC ATTTCACA-TAAGTTATTTATTTTAAATGG-------ATGTAGTGAATTC GTTTCATGTTAATTTAT---TTTTAAACGG-------CTGTAGTAAATTG ***** ** * *** ** ** *** ** * * 1350 ACAGCTATC-------AGTTTTGA-------------------------- ACAGCTTTCCAGTCTGATTTTTTT-------------------------- ACAGCTTTCCAGTCTGAGATATATATATATATATATTATATATAATATAT ACAGCTCTC-------ATTTTGAC-------------------------- GCACTCCTT-------GGTTTTGA-------------------------- ** * * 1400 ------------------TTTTGCAATAAATAAACCACTAGGTTGCATGT ------------------TTTTCCCCCCAGTAAGTCACTAGA-TGCATAT ATATATTATATATATATATTTTG---GCAGTAAGCCATTAGA-TGCATAT ------------------CTTTA----CAATAAACCACTAGACTCTATAT ------------------TTTCACAATCATTATGCAATTTGGCTGTATAT ** * ** * * * * ** * 1450 CGAACAAATTTTT--------------------ATCTCAAATACCAACCA TGAACAAATATTT--------------------GTCTCAAAAATCAGCCA TGAACAAA-ATTT--------------------GTCTCGAAAATCAGCCA TAGACAGATTTTT--------------------ATCTCAGATACCAACCA TGTATATATATGTTTGATAGACTTGTGAGTAAAGTGTCACATAGCAAACA * * * * * * ** * * ** ** 1500 TCA--GT-------TTTTTTTTTC-----ATGTGTTTTGGTACAGCTAAT CCA--GT-------GTTCTTTTGC--------TGTTT--------CTAGC TCAAGAG-------TTTATTTTGC--------TGTTT--------CTAGC TGA--GT---AAAAATTTTTGGCT--------TGTTTTAGTAGAACTACT TCA--ATAGA----TTTTCTTTTCCCTCAGTCCGTTTTGGTACGGCTGCT * ** * **** ** 1550 TCC-T-AATTGTAGAGTGTTA----A-----ATGTTTGAGGAGAACCTTT TC-----ATTACAGAGCGATC----A-----TCCTTTGAGGAG---TTGT TT-----ATTACAGAGTGATC----A-----TCCTTTGAGGAG---TTCT TCCTT-AAATGTGCAGTGTTA----AGTCATATCTTTGAGGAAAACCTTT TCC-CAAACTGCATAGTATAAATCGA-----ATCTTTCAAGTAAACATTT * * * ** * *** * * * * 1600 TCTCA-TAGATGGTTGGTGTTCATATGGCTACTTTACAATAAAGAGAACT CTTCAGGAGATGGTTG--------ATGGTTACTCCACTGAGTAGAGACCT CTTCAGTAGATGGTTGATGTTGGGATCAT--CTGTACTGAGTAGA----- CTGCA-TAGATGGTTGGTGTCCATATGGCTACTCAGCTGAATAAAGAACT TTTCA-TGGATGGTTAATGTCCATATAGCCAC----CAATCCAAATAAGT ** ******* ** * * * * 1650 GTAAGTGATATTTGGAAACTACAAACCTGGAATTAGGAGATATAA----- CCAAGTGGTA-TTGGAAGCAGCAAACCTGGAGT---GAGACATAA----- --------TATTTGGAAGCAG-AAACCTGGAAG---GAGACATAA----- GTAAGTGATATTTGGAAACTGCAAACCTGGAATTAGGAGGCATAA----- ATAA--TATGCTGGTAAGTAGCAAACCTGGAATTGGAAAAGAAGAGAGGG * * * ** ********* * * * 1700 --------------TTATTCCTTCAAGTTTTATAGAATATCACTTGGGAG --------------TTA-TCCTTCAGA--CTGGAGACTGTCAGTTGTGAG --------------TTA-TCCTTCAGA--CTGTAGACCATCAGCTGTGAG --------------TTACTCCTTTAAGTTATACAGAATATCGGTTGTGAG GAATTGTCTCTTCCTTTTTCATTCAAGTTATACAGA-----GCCTTGAAA ** ** ** * * *** * * 1750 AT--TCCAAAGCCATAGCTATTACGCGGCAAACCTAGGATAAGAAAG--- -------AAAGCCACTGTGGTCACATGGCTAGGCTAGTTGAA-------- -------AAAGCCATTATGGTCACATGACTAGTCTAGTTTA--------- AT--TCCAAAGCCATAGCAATTACACAGAAAACCTAGGTTGAGAGAGGTA ATCCTCTAAGGTTTCAGCT------------------------------- ** * 1800 GTAGTA-TGAG-TGCTGGTAGACCAGCTGCA---ACTTTCCT-------A --AGTGCCGAG-TTCCAGCAGG-CGGCTGCT---GCTGTT---------- --AGTGCTGAG-TCCCAGCAAG-CAGCTGCT---GCTTCT---------- GTAGTA-TGAG-TGCTGGTAGACCAGCTGCT---ACTTCCTTCCTATGAA GGAGTA-AGAGCTGCTTGTAAATCGGCCCCATGTCCTTTTGA-------A *** *** * * * * * ** * ** 1850 TACAGTGA------AAAAGGCTGGT----GAAA--CAAGTACAGT----- TCCAGTGAGTACTGAAAAGGCTGATGTTAGAAC--TGAGTATAGT----- TCCAGTGAGTACTGAAAAGGCTGGTGT--TAAC--TAAGTACAGT----- TACAATGA------AAAAGGCAGGT----GAAACTCAAGTACAGT----- GAGAATGA------ACAGGGC----------AT--CCAGTACAGTTTACT * *** * * *** * **** *** 1900 ------CCAGATTTTTTAAAATCATACTTTCTCAGGGATCTCCACAA--- ------CCGGA-GTTTAAGCATCATATTTTCTCAGGGATCTCCACAA--- ------CCGGA-TTTTAAGTATCACATTTTCTCAGGGATCTCCACAA--- ------CCAGA-TTTTTAAAATCATACTTTCTCAGGGATCTCCACAA--- CTAACCTCAGGTACCATCCAGATAGACACTCTGAGGACACATTACTAGTT * * * * *** *** * ** * 1950 --ACTGGTGGGTGTCCTGGCTG---T--CTGTGTGATAG-CCTCTT---- --ACTAGCGGGTGTCCTCGCTG---TCCCTGTGAGACAG-CCTCTG---- --ACTAGTGGGTGTCCTCGCTG---TCCCTGTGAGACAG-CCTCTG---- --ACTAGTGGGTGTCCTGGCTG---T--CCCTGTGACAGCCCTCTT---- CCAGTGCTGTGTGCCCTGGCTTGCCC--CCCTGCAGCAG-CCTGCTGGTG * * * *** *** *** * ** ** *** 2000 -TCTATAGGTGAGGCCTCAAATGAATTGCAGCTATCCTGGT-----GTTC ---TACAGGAGAGGCCTTAAGTGAATTGTCACTGTCCTGGA-----GGTC ---TACAGGAGAGGCCTTAAGTGATTTGTAGCTGTCCTGGT-----GTTC -TCTACAGGTGAGGCCTCAGATGAATTGCAGCTATCCTGGT-----GTTC GGATGTGGATGGGGAAACAAACCACTCAGATTCACAATGGGCAGTAGACA * * * ** * * * *** * 2050 CTATGAGGGCA--CTTTGTATGAAAAAGGGC----ATGTACTCCAAAA-- CTCTGGAGACA--C------TGAGAAGCTGCATGTATGTACTCCAGAG-- CTCTGGGGACA--C------TGAGAAACTGC----ATGTACTCCAGAA-- CTGTGGGGGCA--CTTTGTATTAAGAAAGA-----GTGTACTTCTAAA-- GTAGAAGGGAAGTCTCTTTTCAGGATAGAGT----GTCTTCTTCTTAATG * * * * * * ** * * 2100 ---C---ATTTTTGTAGGTTCTTTGGCCAGTTGCCAAAGAGTGTGAAAGA ---CCTGGTTTCTGT--GCTCTCC-------------AGAACATGAAAGC ---CAGGTTCTCAGT--GTTCTCC-------------AGAGTGTGACAGA ---CT--TTCTTGGTAGGTTCTTTGGCCAGTTGCCAAAGA--CTGAAAGA GCCC---TTTTTTGTAGGTTCTTTGGCTAACTGTCAAAGACCA-GAAGTA * * * ** * *** *** ** 2150 ATCC--AATAGAGGATTTTTCTTACTGATAGCAGTC-ATTCATTGCAGTA GCCC--AGCAT-GGACGTTGCTTACTGGGAGTAGT--------------- GCCC--AGCAT-GGAC-TTTCTTACTGGTAGTAGT--------------- ATCC--AACA--GGATTTTTCTTGCTGATAGCAGTTAATTCATTGCAGT- ATTTTGACTTAAAGGTTTGTTTTGTTGGAATTGAAA-AGTTTTCAGAGCA * * * ** ** * 2200 AAATA---AAATATGATCCCATTAGGG-----------------AATCTT AAATT---AAGTATGAGCCCAGTAGGG-----------------AGTTGT -AATG---AAGTACGATCCCCGTAGGG-----------------ATTTGT ---CA---AAGTATGATCCCAGTAGGG-----------------AATCTT AATGACATAGATTTGAGCACAGTAGGGGAGGGGAAAAAAAAACAAACCCT * * ** * * ***** * * 2250 G---A---ATTCTGA-CCTCCCATACTCCGTTTTGA---AATAACCACTT G---A-----------------------CGTTTTGATGGAATAACCTC-G G---A-----------------------CATTTTGCTGGAATAACCTCTG G---AACAATTCTGATCCTCCCATGTTCTATTCTGA---AATAACCACTT GAGAA---ATCCTAA-TCTTGCAT------TTCTGG---AATAGTCACTT * * ** ** **** * * 2300 TATATTTCA-------TTTTTT---AAAAATCTGA--TGATC-------- TGTATTTCA-------TTTATT------TTCCTGG--CGATC-------- TGTATTTCA-------CTTATT-----TTACCTGG--CGATC-------- TATATTTCA-------TTTATTTTCTTTTATCTGG--TGATC-------- TAATGTTTAGGTTCTCTTCTTT---AAACATGGGACCTGATCATGGAATG * ** * * ** * **** 2350 -----------TCTTTGAGGCAGGTTTC---AGA-TTTGGCAGTACAACA -----------TCT---GAGCAGGCTTC---AGATTTTGACAGT----TA -----------TCT---GAGCAGGCTTC---AGATTTTGACAGT---TCA -----------TCTTTGAGGCAGGCTTC---AGAGTTTGGCAATGCAACA AGTTTTGGCCATATTTTGGTCATGTTCCTAAATG-TGTAGCAGTACAACT * * ** * * * * * * ** * 2400 TG-AAAGATTAGGAAA-----------------AGCAT------TAATAA TG-AAAGATC----CA-----------------AGCAT------TAAT-- TG-AAAGAT-ATGACG-----------------AGCAT------TAAT-- TGAAAAGAATAGGAAA-----------------AGCAT------TGATGA TG-AATGAATGGGGAAGCTGGAGGGGGGAGGGGGGCGTAGAGGACAGGGA ** ** ** ** * 2450 CGTGTGG-GTGGAAAGCTTGTT-----AAAAATCTGAGAGTGAAGTTTGA -GTGTGG-GTGAAAAGCTTGGT-----GAAATTCT--GAGTGAAGTCTTA -GTGTGG-GTGAAAAGCTTGGT-----GAAATTCT--GAGTGAAGTTTTA AGTGTGG-TTGGAAA-CTTGTT-----AAATATCTGAGAGTGAAGTTTGA CACATGACGAGGGATGCTTCTTTTGGCAGTGATCTGAGAATGAGTTTTAG ** * * *** * *** ** *** * * 2500 GTTAAAAGTTGTTTGAACATGGCATTG--ACTGGGAGGCCAAAGATTTAA GTT-AAAGTTGGTTGAACTTGGAATTG--ACTGGGAGGCCAAAGATTTAA GTT-AAAGTTGGTTGAACTTGGAATTG--ACTGGGAGGCCAAAGATTTAA GTTAAAAGACATTTGAACTTGGGATTG--ACTGGGAGGCCAAAGATTTAA ATTAAAGGGTG-TGGAACTTGGTATCGGTATCAGGAGGCCAAAGATTGAA ** ** * * **** *** ** * * ************** ** 2550 TGTGTGA (miR-377) human/mouse/rat/dog/opossum AGAAGCGGAAGATTCTTCTCTTAAGACATG--AGGAGTAAGTTGTGTGAT A-AAGCAGA------TTTTCTCAAGACAC----------AGTTGTGTGAT A-AAGCAGAAGA---TTCTCTCAAGACAC---------AAGTTGTGTGAT A-GAAGAGAAGA---TTCTCTCAAGACACG--AGGAGTAAGTTGTGTGTT GGAAGCAGAAAAATCT----------CATGGCAGGAGTAAGTTGTGTGAT * ** * ** ********* * 2600 AATGGTATGTGTTTTGTGTGCATGAATG-GACATTGTAA---A----TGT AATGGTGTGTGCTTCGTGTGTGTGCGTGAGACTTTGTAA---A----TGT GATGGTGTGTGTTTTATGTGTGTGCATGAGACTTTGTAA---A----TGT AATGGTGTGTGTTTTGTGTGCATGAATG-GGAATTATAAATGA----TGT -GTAGCATGTGTTCTGTGTGCATGAATG-GATATGATTC---AATGGTGT * * **** * **** ** ** * * * * *** 2650 GACAATC (miR-219) human/mouse/rat/dog/opossum TGAATTCTA-----------GGCTCCGACAATCATTGTCAACAGAAGATC TGAATTCTA-----------GGCTCCGACAATCATTGT--AGTGCAGATC TGAATTCTA-----------GGCTCCGACAATCATTGT--AGTGCAGATC TGAATTCTAGGTGAATTCACGGCTCCGACAATCATTGTCAACAGAAGATC TGAATACTA-----------GGCTCTGACAATCATTGTCAACATAAGATC ***** *** ***** ************ * ***** 2700 AAGCTGCA-A--ATATTTATGTTTTAAAA-CTTAAATTATAAAGCTAGTT AGACTGCAGA--ATATTTATGTTTT-AAA-TTTAAATTATAAAGCTAGTT AGACTGCA-A--GTATTTATGTTTT-AAA-TTTAAATTATAAAGCTAGTT AAGCTGCA-A--ATATTTATGTTTTAAAA-CTTAAATTATAAAGCTAGTT AAGTTGCA-ACTATATTTATGTTTAAAACTTTTTAATAATGAAACTAGTT * **** * *********** ** ** *** ** ** ****** 2750 AAGTCTTTCT-------AATGACTAGTTTTAATGTTCATGGGTACAT-TT AAGTC-TTCT-------AACAACTAGTTTTAATGTTCATGAGCAAAT-TT AAGTCTTTCT-------AACAACTAGTTTTAATGTTTATGAGCAGATGTT AAATCTTTCT-------AACCACTAGTTTTAATGTTCATGGGTACAT-TT ATGTCTTCCTTTAAAAAAACACCTAGTTTTAATATTCATGAGTACAT-TT * ** * ** ** *********** ** *** * * ** ** 2800 TACCTAAGTTACCGTTTACATTGTATAGA---AAAAGAT--ACATCT-TA TGCCTACATTACCTTTT-CAAGATGTTGA---AAAAGAT--GCTTCCGCA TGCCTACATTACCTTTT-CAAGATGTTGA---GAAAGAT--GCTTTG-CA TATGTAAGTTACCTTTTACATTCTATATG---AAAAGAC--TCATGT-TA TA-TTGGGTTTCTTTTTATAGTATATGAATATAAAAAATTGCCATCT-T- * * ** * *** * * * *** * * * 2850 AGCACAGATTGGTTATTA----------------GGAA---TTAG----- AGCCCAGGTTGGAAGCTG----------------GGAG---GTGGGTGGT AGCACAGGTTGGAGGCTG----------------GGAG---CTGGTTGGT AGTACAGATTGGAGATTG----------------GGAA---TCAG----- --------TTGGTAATTATTTAGCAGAGACCTATAGAAACCTTAG----- **** * ** * 2900 TTTGGGGAAGAGGTTTTTTTGTGGATTCTTTCATACTGCAAAGAAAAACC TCTAGGAGAGA----TCTTTGTGGATTCATTCTTACT-CAA--------- TCTTACTAAGG-----TTTTGTGAAGTCTT---TGTTGCAGAGGAAAACA TTTGGGGAAGAGA---TTTTGTGGATTCTTTCATCCTACAAAAGAGAAAA TTCTGGAAAGAGGTTTTATTA-GGACCCTTCACATCTCTTAAGCAAGAAA * ** ** * * * * * 2950 ATTTGCC---------TTTTGGGGAA-TTGAGCTAA-CTTCTAATCTAGT ---TGCC---------TTCTGGG--A-TTGAG-TAA-GTTTTAATCTATT A--TGCC---------TTCTGGGG-C-TTGA--CTA-GTTTTAATCTAGT ATTAGAT---------GTCTGGGGAA-TTGGACTAATTTTCTTATCTAGT ATTTGCCATCTACAGATGTTGAAGAGCTTTAGTAAT-ATTCTAATCCAGT * ** ** ** * *** * * 3000 CT-TAAGACTAGAATGC-TAAAAACAA----AAACATGAAGGAAATTAA- CTGTAAGATTAAAAGGA-AAAAAACAA----AAACACAATGGAAATTAA- CTTTAAGATTAGAAGTA-AAAAAACAA----AAATACAAAGGAAATTAA- TTTTAAGACTAGAATGCTAAAAAACAA----AAATATGAAGGAAATTAA- TT-TAAGACTAGTCTG---AAAAACAAAGTTAAATGTAACAGAAATTAAC * ***** ** ******** *** * ******** 3050 ----AACCCCTTATTATTAAATTGATTTGTAAAAACATTGTTACTGGAAA ----AACCTC-----ATTAAATTAGTCTTTAAAAACATTGTTACCTGAGA ----AACCTC-----ATTAAATTAGTCTTTAAAAACATTGTTACCTGAAA ----AACCCCTTATTATTAAATTGATCTGTGAAAACATTGTTACTGGAAA AAATAACTC--GATCATTAAATTGAT---CAAGACCTATGTTGCTGCAAG *** ******** * * * * **** * * 3100 -------TTTA-T-----------------TGGACTT---GAGGCCTTCC -------TTGAGT-----------------GGGACTTTTGAGGGCTTTGT -------TTGAGT-----------------GGGACTTTTGAGGGCTTTCT -------TTGAGT-----------------GGGACTT--GAGGCCTTTCT ATAACTTTTTG-TTTTCCTGGGTAGTAGGCTGAACTT---TAGGCCTTTC ** * * **** * * ** 3150 T-CCAGAAAATAAGGACT---TGATTGTCAGGCCTATATTAGGTTCTGAA T-CCAGAAAACAAGGACC---GGGTCCTCGGGCCTACATTAGG--CCTGA T-CCAGAAAACAAGGACT---TGGTCCTCAGGCCTATATTAGG-CCTGAC T-CCAGAAAACAAGGACT---TGATTGTCAGGCCTATATTAGGTTCTGAA TCCCAGCAAGCAAGGACTTTGTGACAGTCAGGCCTATATTAGGTACTGTC * **** ** ****** * ** ****** ****** * 3200 CCTTAATGCCATGTATTTGTACTTACTAAAAATTGTTTCAATGAAAAGTA CCCCGGAGCCATGTGTTTGTGCCT----AAAATCATCTCAGTGGGAAGTA CCTTGGTGCCATGTAAGTGTACTT----AAAGTCTTTTCAGTGGAAAGTA CCTTAATGCCATGTATTTGTACTTGTTAAAAATTGTTTCAATGAAAAATA CTTTATTGCTATGTATTTTTGCTTA------------TCGATTTAAAGTA * ** **** * * * * ** * ** ** 3250 CATTAGCAG---TATGAACTTCTGG--TCCAGT---TGGAAGTTTTTCCA TCTTAGTGACTCTAGAGACTCCCGG--GACAGT---GGGGGGGTCTTCCA TCTTAGCGA---TCGGAACTTCTAG--TACAGT---TGGGAGTTCTTCCA TATTAGTAA---TATGAACTTCTGG--TTTAGT---TGGGAGTTCTTCCA AATCAGTAA---TTCCAAATACAGATTTCCAGTAAATAGAAATTTT---A * ** * * * * *** * * * * 3300 TTTGAAAAATGTGATGTTTGCATGGAACTGTTTGAAACTTTTTTATTTTC TTTGAAAACTGTGATACTTGCATGGGATTGTTTGAA----TCTTGTTTCC TTTGAAAC---TGATATTTGCATGGGATTGTTTGAA----TCTTGTTTTC TTTGAAAAATGTGATATTTGCATGGAACTGTTTGAA---TCTTTGTTTTC TTTGGAATAGGTAGTATTTGCATGAAAATGTCT--CATCTTTCAGTTTTT **** ** * * ******* * *** * *** 3350 T-AGTCCCCC--TCCCCCACACTG----GATAGAATTTAGCCTAGAATTT T-AGTCTCCCTTTCCCCATCACTACCCTCATAGTCTGAAG-GTAGATTTT T-AGTCTCTC---CCCCATCACTACCCTCATAGTCTCAAG-GTAGATTTT TCAGTTTCCC------CTCCACTG----GATAGAATTGAAACTAGAATTT T-ACT-----------------TG----GATAGAAGTGAAGCTAGAATTT * * * * **** * **** *** 3400 TC-------CCTTTGGATAAAAGAACA--AAAATTGAACATGTTATT--- TC-------TCTT--GATAAAGGAACAC-AAAAATGAACATCTTACT--- TT-------TCTCTTGATAAAGGAACACAAAAAACGAACAT----CT--- TC-------CCTTTTGTTAAAGGAATA--AAAAGTGAATATGTTATT--- TTGGCAGTATATTAAGAGAAAGTAACA--AGAAAATAACATTCTATTCAT * * * *** ** * * ** ** ** * 3450 ---TGTAAATTGATGTTTA---GTAATTAGTGATAAACT--TGAAATACT ---TGTAAATTGATATCTA---GTAACTAGTGGTAAACT--TGAAATGGT ---TGTAAATTGATATTTA---GTAACTAGTGGTAAACG--TGAAATGGT ---TGTAAATTGATGTTTA---GTAACTAGAGATAAACT--TGAAATACT ATGTGTAAGTTGACACTTCTGTATTATTGGTAACAAACTACCGAAATACT ***** **** * * * * * **** ***** * 3500 AGCATATATTATAAGCCTTAAT---CTT----AGGTAGTCTTATGAAA-A AGCATTCTTTACAG--CTTAAT---CCT----AGGTAGCCTTAGAGAA-A AGAATTCTTTACAG--CCTAAT---CCT----AGGTAGCCTTAGAGCA-A AGAATACACTATAAG-CCTAAT---CCT----AGGTAGTCTTATGAAA-A ATAGTGTGTGA----CCCTAATTAACTTATACAGTTGGTCTTCTAAAATA * * * * **** * * ** * * *** * * 3550 TGAATCTCTTAACTATCTTTTGAAC----CTGTAT-TCACATTGGTT-TT TG--TGTCTTTATTAT-TTCTGAAC----CTGCAT-CCATCTTGTCTGCC TG--TATCTTAATTAT-TTTTGAAC----CTGTAT-TCTCCTTGTCTTTT TGTATCTCTTT-TTATCTTCTGAACCTATCTATAT-TCACATTGCTC-TT TGTATTTCCT--TTGCCCTTTAAAC----TTAAGTACCATATTGGTT-C- ** * ** * * * * *** * * * *** 3600 CAAGATATTTTAAGTTATATTTTTTCCTCTTTTCAGAGCTGCTTCTTATT CAAGCTGTCTTAAGTTATG---TTTCCTTTTTTCAGAGCTGCTTTTTATT CAAGATATCTTAAGTTATA---TTTTCT-TTTTCAGAGCTGCTTTTTATT CAAGATATCTTAAGTTATATTTTTTCCTCTTTTCAGAGCTGCTTC---TT -------------------TTCCCCCCCCATCCCA----TCCCCAGTATT * * ** * * ** 3650 CTGGGGCTACTTTTT-TTTTTAGTT-------GTGTAATTCACAAAGGGC TTGGGGCTACTTTTT-TTTTTTTTTAATTGAGGCGTAAATCATAAAAGAC TTGGGGCTACTTTTT-TTTAAAAAT---TGAGGCGTAATTCATAA--GAC TGGGGGCTACTTTTT-TTTTTATTG-----AGGTGTAATTCATAAGGGGC TTCAATTTATTTTTTAGTTCTATTT-------TTATTTTCCAGTCATAGG ** ***** ** * ** 3700 TGCattttttttt-----ttttttaat--aaGG---CTTATAACTAT--- TACA--------T-----TGCTTTGATGAGAGA---CTTTTTACACC--- TACA--------C-----TGCTTTGAC--GAGA---CTTTTTACAACTTA TA----------C-----TTTTCTGAT--AAGG---CTTCTTATAACTAT TGCTTCTTTTTCTAGAGGCTTGTTGAT--GATGCCTCTTGTAGATAT--- * * * * *** * 3750 GGCTGGATCTTTTGCTCTAGTCTTCTAAGAAGGGCCATTTTATT-TTTTA GTCAGGTTGTCTTTGTCTAGTCTTCCAAGAAGGGTCATTGTGCT-TTTTT GTCAGGTTGTCTTTGTCCAGTCTTCCAAGAAGGGTCATTTTACTGTTTTA GGCTGGATGTTTTGTTCTAGTCTTCCAAGAAGGGCCATTTTATT-TTTTA AAA-------TCTGCTCTTGTCTTTCATGCTTGGCC-----CAT-TTCTG * ** ***** * * ** * * ** * 3800 GAGTCACTTCTAAAGTC-------------------ATGTGGTAATTAAC AGATAAATCCTGA---C-------------------ATGGGCTACTT--- GATTTACTTTTAAAGTC-------------------ATGGGTTACTT--- GAGTCACTTCTAAAGTC-------------------ATGTGGTCTTTAAC GAGCCACTTCTCAGTTTGAACTATGTTGGGGGGAAGATATATTAATTGAC * * * * ** * ** 3850 -TTTGGAGACTGTTTTGCGTATGAGTGCTGATACAAA-----TTAAAACC ---------------------------CAGATGCAAA-----GTAAAACC -------------------CAAATGTAGAAATGCAAA-----GTAAAGCC -TTTGGGGACTATTTTGCATATAAGTGCTAATGCAAATAAATTTAAACCC TTTTGGAGGTC--------------------CATAAC-----TTTACACA ** * * * 3900 CAAGTAGACCTCA--TTGCATGTC-ACCCTATGAATGTTGACAATGGAAG CAAGC---TCTCACCTCACGTGTT-TCACTCTGAATGTGGCCAGCGGAAG CAAGCTCACCTCA--TCG---GTT-TCGCTCTGAATGTGGACAACGGAAG CAAGTAGACCTCA--TCACATGTC-ACCCCATGAATGTTGACAATGGAAG GAAGCAACCCCCA--TAGCATATTGGCCCTGTGTGTTTTGAATGAGGAAT *** * ** * * * * ** * * * **** 3950 GAATACCTTGCCTG-TAGTATA-CTGTCACTTCTGGATTGATAAGCTGAG ACACGACTTGCCTGTTAGCACA-CTGTTACTTGTAAACGGAAATGCT--- GAACGACCTACCTGTTAGCATC-CTGTTACTCGTAAACTGAAACGCT--- GAATACCTTGCCTG-TAGTATA-ATATCAGTTCTGGACTGAAAAGCTGGG TTGAAACTTGCTGT-TAGTGTAGTTCTCAATTCTGGACAGAGGCTCAAAG * * * *** * * * * * * ** * 4000 GAAGAAAGTTAAGTTTCTTTTTTACATAAGTCA---------GAAAAACT GAAGACACTCAGCTTTCTTT----------ACA---------GAAAA--- GAAGAAACTCCGTTTTCTTT----------GCA---------GAAAT--- GAAGAAAAT----TTTCTTTTTTGCATAAACCA---------GAAAA--- GCTGAAGTTTTTCTTTTTTTTTTATATAAACTGCAAAACGGTGAAAACTT * ** * *** *** **** 4050 TACAGCTGGTGTTCCTAGTTTCCTGGTTGACCTCAGCAGATGAAGTGAAC ------------TCAAGGTTTCCTGAT--GACTGGGCACATGAGGTGAGC --CAAGGTCTATCTAAGGTTTCCTGACT-GCCTGAGCACATGAGGTGAGC -ACCGCTAGTGTGC--AGTTTCCTTGTTGACCTCAGCAGATGAACTGAGC GACAGCCTATGTG--TTGTCACCTTGCTGACCTCAGCAGAATAACTGAGC ** *** ** *** * * *** * 4100 AGATAGTGTTAATTCAGATTGAAGAAATTATCTGAATCTTGGTTTGTGTA TGACAGTCTTGGTTCAGGGTGA----------------TCGGATTGTGTA TGAC-GTCTTAGTTCAGAACAA----------------TCTGAC--TGTA TGATAGTGTTATTTCAGATTCGCGAAATTATCTGAATCTCGGTTTGTGTA TTATAGTGTT-ACTCAAATTCAAGGAATTCCTTGAGTATTGGTTTGTGTA * ** ** *** * * **** 4150 GATTTACAATCTACATGCAATATTAACTAA----A-TCAGATAGCTTTTA GACTGACAGTCT--GTGTACTGCTGGCTAA----G-TGTGATAGCATCTG GATT--CAGTGT--GTGTCCTGCTGGCTGAGGGCA-AGCGAGGGCTTCTA GACTTGCAATCTACATGCAATTTTAACTAA----A-TCAGATAGCTTTTA GATCCACAGTCTACATGCAATATTAACCGA----ATTCAGATAGCTAATG ** ** * * ** * * * * ** ** * 4200 CAGTT-TCACATGTGT-ACATAGGTTCCCTCCCGGTCCCTTCCATA---- CAGTT-CT----------------CTCCCTCCCGG--------------- CAGCT-GTGTGTATGTCCCGCAGG----CTCCCGT--------------- CATTT-TCAC-TTTGT-ACATAGGCTCTC-CCCACCCTTTTCAACA---- CAGTTGTTTCACATGT-ACATATGCT---------TTGTTTTTGTAAGAC ** * 4250 TCCATTAGTT-ATTGAACTTTC-T-AAACTGGCATTGAAACA-TTACAAC -----TAGTT-ACTGAACTCTT-TAAAACTGGTATTGTGACG-TTACAAC -----CAGTT-ACTGGACTCTC-A-GAACTGGTCTTGTGACA-TCACAAC TCCATTAGTTAATTGATCTTTG-T-AAACTGGCATTGAAACA-TTACAAC TACACTAGTT-ATTGAACTTTTGT-AAGCTGGCACCGAAACATTTTTTAT **** * ** ** * * **** * ** * * 4300 GTGCAAT (miR-25,miR-32,miR-92,miR-363,miR-367) human/mouse/rat/dog/opossum AATGTTTTGTTGCACCAATTTTATAAACTTAAGCAGTGCAATACGTGT-T AATGTT---TTGCGCCAATTTTATAAACCTTTACAGTGCAATATGTGT-T AATGCT---TTGCGCCAATTTTATAAACCTTTACAGTGCAATATGTGT-T AATGTTTTGTTGCACCAATTTTATAAACTTTTACAGTGCAATACGTGT-T AATGTTCTGTTGCACCATGTTTG-AAGCTTTTACAGTGCAATAAATGTAT **** * **** *** *** ** * * ********** *** * 4350 ACCAAAG (miR-9) human/mouse/rat/dog/opossum ACTTTTCTGAGGCAAACCAAAGGTAAATTTCTCAAGGTTCTTGCTGCCTT ACTTTTCTGAGGCAAACCAAAGGTATATTTCTCAAGGTTC-TGCTGCCAT ACTTTCCTGAGGCAAACCAAAGGTATATTTCTCAAGGTTC-TGCTGCCTT ATTTTTCCGAGACAAACCAAAGGTTAACTTCTCAAGGTTCTTGCTGCCTG TATTTTCTGAAGTAAACCAAAGGTAAATCTCTCATGGTTCTTGCTGCCTG *** * ** *********** * ***** ***** ******* 4400 CTTTAGCAGCATTTGATGGAAGA---TCTTTTATACATTTGTAATAGAT- C---AGCAGCATTTGATGGAGGA-TTTTTTTTATACATTTGTAATAGGT- C---AGCAGCATTTGATGGAAGATTTTTTTTTATACATTTGTAACAG--- CTTTAGCAGCATTTGATGGGAGGATCTTTTATATACATTTGTAATAGAT- CTAGAGCAGCACTT----GAGGA---TCTTTTATACATTTGTAATAGATG * ******* ** * * * ** ************* ** 4450 AAAAATAAACCAGATTGCAA----------------ATCCT--------- AGAGATGAAACAGATTGCAGTTTGTTTTTTGTTATTTTTTT--------- ----ATGAAGCAGATTGCAGTTTGTTTTTTGTTATTATTTT--------- GAA---AAACCAGATTGCAAATCCttttttt-----ttttt--------- AAAAATAAACCAGATttcaa----------------atcctgtttgggtt ** ****** ** * * 4500 -----------------TTTTTAAAATCCTAAACCATGTACCAAGTTTTT -----------------TTTTTTAAATTGTAAACCATGTACCAGGTTTCT -----------------TTTTT-AAATTGTAAACCATGTACCAAGTTTCT -----------------ttttttaaaGCTTAAACCATGTACCAAGTTTTT ttttttgttttgttttgtttttaaa--cctaaaccatgta-caagtcttt ***** ** *********** ** ** * * 4550 GGTCCAAATTATGTAGGATAAGTTAAACTTAAATTGCATTCTATTAACCA GGTCAAGATTGTGTAGGATAAGTTAAACAT-AATTGCATTCTATTAACCA GGTCAAGACTGTATAGGATAAGTTGAACGT-GATTGCATTCTATTAACCG GGTCCAAATTGTGTAGGATAAGTTAAACTTAAATTGCATTCTATTAACCA ggtccaaat--tgtagtgtaaagttaaactaAATTGCATTATATTAACCC **** * * * *** *** * ** * ******** ******** 4600 ATATGAGTGTATTTC-TGTAAGCATAGTTATGTTGAAATAAAGTT--TTA ATATGAGTGTATTTCTTATGCATATAGTTACATTGAAATAAAGTT--CTA ATATGAGTGTGTTTCCTATGCATATAGTTACATTGAAATAAAGTT--CT- ATATGAGTGTATTTC-TGTAAGCATAGTTATGTTGAAATAAAGTT--TTA ATATGAGTGTATTTC-CCTAAGTATAGTTATGTTGAAATAAACTTTATTA ********** **** * ******* ********** ** * 4650 AAAACCA-TGATGCCTTTGTTTATTA-TTGGTATATCCAGAATGTAGGAA AAAACTA-TCGGACCTTTGTTTATTA-TTGGTGTGTC--------AAAGA -AAACCA-TCAGACCTTTGT---TTA-CTGGTGTGTC--------GAAGA AAAAGCATTTATGCCTTTGTTTATTATTTGGTAGGTC----------AAA AAAAGTG-TATTGCCTTGGTGTA--------------------------- *** * **** ** 4700 AGCCAA----ATTTATGTTGCTGGA AGCCGATATCACCTCTTTTG-TGTA AGCCAACAGCACTTG------TGTA TATCAAACCGAATTATTTTGCTAGA ------------------------- 4750