# Aligned 3'UTR sequences of MECP2 in the order of human, mouse, rat, dog and opossum. # Predicted miRNA targeting sites are annotated on top of the alignment with miRNA seeds indicated. # Only miRNAs with seeds perfectly conserved in human,mouse,rat and dog are shown. # Only miRNAs with seeds prefectly conserved in all mammals including opossum are reported in the paper. # >MECP2.utr3 hg17.chrX:152807780-152816680,- mm7.chrX:69413162-69422081,- rn3.chrX:160046240-160055112,- canFam2.chrX:124907967-124917053,- monDom2.scaffold_216:154000-163859,- CGAGAGAGTTAGCTGACTTTACACGGAGCGGATTGCAAAGCAAACCAACA CGAGAGAGTTAGCTGACTTTACATAGAGCGGATTGCAAAGCAAACCAACA CGAGAGAGTTAGCTGACTTTACATAGAGCGGATTGCAAAGCAAACCAACA CGAGAGAGTTAGCTGACTTTACACAGAGCGGATTGCAAAGCAAACCAACA AGAGAGAGTTAGCTGACTTTTGAAAAAGTGGATTTAAAA--AAACAAA-- ******************* * ** ***** *** **** ** 50 GGCAGCT (miR-22) human/mouse/rat/dog/opossum AGAATAAAGGCAGCTGTTGTCTCTTCTCCTTATGGGTAGGGCTCTGACAA AGAATAAAGGCAGCTGTTGTCTCTTCTCCTTATGGGTAGGGCTCTGACAA AGAATAAAGGCAGCTGTTGTCTCTTCTCCTTATGGGTAGGGCTCTGACAA AGAATAAAGGCAGCTGTTGTCTCTTCTCCTTATGGGTAGGGCTCTGACAA AGAATAAAGGCAGCTGTTGTCTCTTCTCCTTCTGGGCAGGGCTCGGACAA ******************************* **** ******* ***** 100 TTCCCGA (miR-425) human/mouse/rat/dog/opossum ACTGAAA (miR-30a-3p,miR-30e-3p) human/mouse/rat/dog/opossum AGCTTCCCGATTAACTGaaataaaaaatatttttttttCTTTCAGTAAAC AGCTTCCCGATTAACTGaaataaaaaatatttttttttCTTTCAGTAAAC AGCTTCCCGATTAACTGAAATAAAAAATATTTTTTTTTCTTTCAGTAAAC AGCTTCCCGATTAACTGaaataaaaaatatttttttttCTTTCAGTAAAC AGCTTCCCGATTAACTGAAATTAAAAAGGGTTTTTTTTTTTTCAGTCAAC ********************* ***** ******** ******* *** 150 TTAGAGTTTCGTGGCTTCAGGGTGGGAGTAGTTGGAGCATTGGGGATGTT TTAGAGTTTCGTGGCTTCGGGGTGGGAGTAGTTGGAGCATTGGG-ATGTT TTAGAGTTTCGTGGCTTCGGGGTGGGAGTAGTTGGAGCATTGGG-ATGTT TTAGAGTTTCGTGGCTTCAGGGTGGGAGTAGTTGGAGCATTGGG-ATGTT TTAGAGTTTCGTGGCTTCAGGGTGGGAGTAGTTGGAGCACTT---AT--- ****************** ******************** * ** 200 AAGCACA (miR-218) human/mouse/rat/dog/opossum AGGGCCA (miR-328) human/mouse/rat/dog/opossum TTTCTTACCGACAAGCACAGTCAGGTTGAAGACCTAACCAGGGCCAGAAG TTTCTTACCGACAAGCACAGTCAGGTTGAAGACCTAACCAGGGCCAGAAG TTTCTTACCGACAAGCACAGTCAGGTTGAAGACCTAACCAGGGCCAGAAG TTTCTTACCGACAAGCACAGTCAGGTTGAAGACCTAACCAGGGCCAGAAG ---------GACAAGCACAGTCAGGTTGAAGACCTAACCAGGGCCAGAAG ***************************************** 250 TAGCTTT (miR-9*) human/mouse/rat/dog CTTTGCA (miR-527) human/mouse/rat/dog/opossum TTTGCAC (miR-19a,miR-19b) human/mouse/rat/dog/opossum TTGCACT (miR-130a,miR-301,miR-130b) human/mouse/rat/dog/opossum TGCACTT (miR-519c,miR-519b,miR-519a) human/mouse/rat/dog/opossum GCACTTT (miR-17-5p,miR-20a,miR-106a,miR-106b,miR-20b,miR-519d) human/mouse/rat/dog/opossum TAGCTTTGCACTTTTCTAAACTAGGCTCCTTCAACAAGGCTTGCTGCAGA TAGCTTTGCACTTTTCTAAACTAGGCTCCTTCAACAAGGCTTGCTGCAGA TAGCTTTGCACTTTTCTAAACTAGGCTCCTTCAACAAGGCTTGCTGCAGA TAGCTTTGCACTTTTCTAAACTAGGCTCCTTCAACAAGGCTTGCTGCAGA CAGCTTTGCACTTTTCTATAATAGGCTCCTTCAACAAGGCTTGCTGCATA ***************** * *************************** * 300 TACTACTGACCAGACAAGCTGTTGACCAGGC------------------A TACTACTGACCAGACAAGCTGTTGACCAGGC------------------A TACTACTGACCAGACAAGCTGTTGACCAGGC------------------A TACTACTGACCAGACAAGCTGTTGACCAGGCTTCTTAGGGTATGCCTGCA TACTACTGACCAGACAAGCTGTTTATCAGGCTTTTTAGGATACACCAGCA *********************** * ***** * 350 C--------------------CTCCCCTCC--CGCCCAAACCTTT----- CTCCCCCCAACAATATCCTCCCTCTTCCCC--CCCCCCACCCCCG----- CTCCCCACAACAACAACC-CCCTCCCTCCT--CACCCCACCCCTA----- C--------------------CTCCCCTCC--CACCCAGACCTCCCCCCA C--------------------CTGCCCTCCAT------------------ * ** * 400 -CCCCC-AT-------------------------------GTGGTCGTTA -CCCC--GT-------------------------------GTGCTCGTTA -TCCCCTGT-------------------------------GTGCTCATTA CCCCCC-AT-------------------------------GTGCTCATTA ---------...............................GTTGTCACTA ** ** ** 450 ACACTCC (miR-122a) human/mouse/rat/dog GAGACAGAGCGAC---A--GAGCAGT-TGAGAGGACACTCCCGTTTTCGG G-------------------GGCAAT-TGAGAGGACACTCCCATTTTTGG GA--------GA-------GGGCAAT-TGAGAGGACACTCCCATTTTTGG GG--------GAC---AGAGAGTGGT-TGAGAGGACACTCCCAGTCTCAG GA--------GACCTAACAGAGTAGGGTTAGTGGGAGCTTACATTTTCAG * * * ** ** ** * * * * 500 TGCCAT----------CAGTGCCCCGTCTACA---GCTCCCCCAGCTCCC TGCCAT----------TGATGCCCTGTCCATAATAGCTTCCCTGACTTTT TGCCAC----------TGATGCCCTGTCCATA---GCTTCCCTGACTTTT CTCTCCTCTCCTCCCGCCCTGCCCCACCC-CC---ATCCCCCCAGCTCCT TGCCAT----------TAACATTC------TA---GT---CCAAGGTCTT * * ** * 550 CCCACCTCCCCCACTCCCAACCACGTT--GGGACAGGG------------ AC-ACCACCCCAACTCCCAATCTGA----AGGACTGGG------------ AC-ACCACCCCAACTCCCAATCTGA----GGGACTGGG------------ CC-ACCTTCCCCATCCCTACCCACATT--GGGACAAGG------------ AA-ATT-------------ATTATGTTGGGGGATTTGGGTTTTGTTTTGT * *** ** 600 -------AGGTGTGAGGCAGGAGAGACAGTT--GGATTCTTTAGAGAA-- -------AGGTGTGATGCAGGAGAAACTATG--GGACTCTTGGGAGAA-- -------AGGTGTGACGCAGGAGAAACTATATAGGACTCTTGGGAGAA-- -------AGGTGTGAGGCAGGAGAGACAGTT--GGATTCTTTAGAGAAAA TTTCCTGAGGGGGGTCGGGGGAGGGGGGATT--CTATTCCTTAGGAAA-- *** * * * **** * * ** * * ** 650 -GA---TGGATATGACCAGTGGCTATGGCCTGTGCGATCCCACCCGTGGT -GACTATGGAGTTGGCCAGTGATTAAGGCCCA-GTAATTCCAACTGTGGT -GACTATAGAGTTGGCAAGTGATTGCGCCCCA-GTAATTCCAACTGTGGT AGA---CAGAGATGGCCAGTGGCTACAGCCTGTGTGATCTCACCCATGGT -GA---GGGTCAAGTCAGACGACAGAGCGCAGAGCAGTTGGCTCTGGGGG ** * * * * * * * * ** 700 GGCTCAAGTCT---GGCCCCACACCAGCCCC-AATCCAAAACTGG--CAA AGCACAGATCT---GGCTCCACATCAACCC--AATCCAAAACTGA--CAA AGCACAAGTCT---GGCTCCACACCAACCC--AATCCAAAACTGA--CAA GGCACAAATCT---GGCCCCACGCCAGCCCC-AATCCAAAACTGA--CTA AGACCTTGACTAGGGGCCAGGTGGCATCATCTAATCCCAAGGGGCTCCAA * * ** *** ** * ***** ** * * * 750 GGACGCTTCACAGGACAGGAAAGTGGCACCTGTCTGCTCCAGCTCTGGCA GGATATTTTGCAAAAAAAGAAAGTGGCACCTGTCTGATCCAGCTCTGACA GGACATTTTGCAAAAAATGAAAGTGGCATTTGTCTGATCCAGCTCTGGCA GGACATTTCACAGGACAGGGAAGTAGTACCTGTTCACTCCAGTTCTGGCA GTGAGTGTTAGGGTAGGGAAAGATGTTACG-------------------- * * * * * * 800 TGGCTAGGAGGGGGGAG-----------TCCCTTGAACT------ACTGG TGGCTAGAGGTGAGTC----------------CTAAACT------GATGG TGGCTAGAGATGAGTC----------------TTAAACT------GTTGG TGGCTAGGAGGGAGTCA----------GTCCTTTGAGCT------GCTGG ---CTAGGAGAGAAGCCTAAAAGAAGAGTGGTTAGAACCCTTCCCACTGG **** * * * *** 850 -GTGTAGACTGGCCTGAACCACAGGAGAGGATGGCCCAGGGTGAGGTGGC CTTATAAACTAGCCTGAGCCACAGAAGAGTATGGCCCAGAGTGAAGTGTC CTTATAAACTGGCCTGAGCAACAGAAGAGGATGGCCCAGAGTAAAGTGTC -GTGTAGACTGGCCTGAGCCAGAGGAGAGGATGGCCGAGGGC-------- -GAGTTGACTT--------------GGAAGTAGGCCC------------- * *** ** **** 900 ATGGTCCATTCTCAAGGGACG-TCCTCCAACGGGTGGCGCTAGAG----- ATCATCTGTTCACAAGGCATGCTCCCCTAGAAGATAATGCTAAAGAG--- ATCATCTGTTCACAAGGCATGCTCCCCTAGAAGTTCATGCTAAAGAA--- -------------------CG-TTCTCCAGTGGGTGGCgagagagagaga --------oooooooooooooooooooooooooooooooooooooooooo 950 ----------------------------------GCC-ATGGAGGCAGTA --------------------------------GTGCC-ATGGAGGCAGCA --------------------------------GTGCC-ATGGAGGCAGCA gagagagagagagagagagagagag---------GCC-GTGGAAGCAACG oooooooooooooooooooooooooooooooooooooooooooooooooo 1000 GGACAAGGTGCAGGCAGGCTGGCCTGGGG---TCAGGCCGGGCAGAGCAC GGACAAAGTACAGGCAGGCTAGG-TGGAG---TCAAGCCAGGCCTAGTGC GGACAAAGTACAGGC----TAGG-TGGAG---TCAAGCCAGGCCTAGTGC GGACAAGGCGTAGGCAGGCTGGCCCCGGGCTCCTGGGCTCCTCCGGGTGG ooooooooooooooooooooooooooooooooooooooooooooooGTAT * 1050 AGCGGGGTGAGAGG--------GATTCCTAATCACTCAGAGCAGTCTGTG CACAGAACAAGAG--------------------------AGCAGTCT--G CACAGAGCAAGAG--------------------------AGCAGTCTCTG CACAGAGCAGTGGGGCTCATGGAATTCCTAGTTGCTCAGAGCAGTCTGTG GTCCGGATGAGAG-------------------TGCACAGGGTGGGCT--- * * * * * ** 1100 AC--------------TTAGTGGACAGGGGAGGGGGCAAAGGGGGAGGAG AC---------------TAGTAA-------------TTAAGAGGGAAGAA AC---------------TAGTAG-------------TTAAGGGGGAAGAA ACTGGTAGGTAGAGGCCTAGTGGACAGGTTGGGGGGCCAGGGGGAAGTAG -------------------------------------------GGGAGAA * * 1150 AAGAAAATGTTCTTCCAGTTACTTTCCAATTCT---CCTTTAGGGACAGC AGGAAAATATTCTTCCAATTACTTTCCAGTTCT---CCTTTAGGGACAGC AGAAAAATATTCTTCCAATTGCTTTCCAGTTCT---CCTTTAGGGACAGC GGGAAAATGTTCTTCCAAA-ACTTTCCAATTCTACTCCTTTAGGGACAGC AGAAAAATGTTCTTCCAATTCTCTTCCAGTGCTATTAGCTTAGGGACAGG ***** ******** ***** * ** ********** 1200 TTTGCAC (miR-19a,miR-19b) human/mouse/rat/dog/opossum TTGCACT (miR-130a,miR-301,miR-130b) human/mouse/rat/dog TTAGAATTATTTGCACTATTGAGTC----TTCATGTTCCCACTTCAAAAC TTAGAATTATTTGCACTATTGAGTC----TTCATGTTCCCACTTCAAAAC TTAGAATTATTTGCACTATTGAGTC----TTCATGTTCCCACTTCAAAAC TTAGAACTATTTGCACTATTGAGTC----TTCATGTTCCCACTTCAAAAC TTAGAAGTATTTGCACAATTGTGTGATCGTTCCCATCCCCACTTCAAAAC ****** ********* **** ** *** * ************* 1250 GCTTGAA (miR-498) human/mouse/rat/dog AAACAG------ATGCTCTGAGAGCAAACTGGCTTGAATTGGTGA----C AAACAG------ATGCTCTGAAAGCAAACTGGCTTGAAATGGTGA----C AAATAG------ATGCTCTGAAAGCAAACTGGCTTGAAATGGTGA----C AAACA--------TGCTCTGAGAGCAAACTGGCTTGAATTGGTGA----C AAACTGGCTGAAATGCTC-AACAGAAGACTGGCTTCAATGGGCGATCTGC *** ***** * ** * ******** ** ** ** * 1300 ACTACCT (miR-196a,miR-196b) human/mouse/rat/dog ATTT---AGTCCCTCAAGCCACCAGATG-TGACAGTGTTGAGAACTACCT ACT-----GTCCCACAAGCCACCAGACA-TGGCAGTGTTCAGAACTACCT ACT-----GTCCCACAAGCCACCAGACAATGGCAGTGTTCAGAACTACCT ACTT---TGTCCCTCAAGCCACCAGACA-TGACGGTGTTTAGAACTACCT CCTTGCCACTCACCCAAGACACT-GGCT-TGATGGGGTTCTGAATTCCCT * ** * **** *** * ** * *** *** * *** 1350 GGATTTGTATATATACCTGCGCTTGTTTTAAAGTGGGCT--CAGCACATA GTATCTGTATATA--CCTGCGCTTGTTTTAAAGTGGGCT--CAGCACATA GTATATGTATATA--CCTGGGCTTGTTTTAAAGTGGGCT--CAGCACATA GGATCTGTATATA--CCTGCGCTTGTTTTAAAGTGGGCT--CAGCACATA ----------CTA--TCTGCGCTTGTTTTCAAGTGGGATATTAGCACACA ** *** ********* ******* * ****** * 1400 GGGTTCCCACGAAGCTCCGAAACTCTAAGTGTTTGCTGCAATTTTATAAG GGATTCCCAAGAAGCTCCGAAACTCTAAGTGTTTGCTGCAATTTTATAAG GGGTTCCCACGAAGCTCCGAAACTCTAAGTGTTTGCTGCAATTTTATAAG GGGTTCCCACGAAGCTCCGAAACTCTAAGTGTTTGCTGCAATTTTATAAG GGGTTCCCACGAAGCTTCGAAACTCTAAGTGTT-GCTGCAGTTTTATAAG ** ****** ****** **************** ****** ********* 1450 GACTTCCTGATTGGT-TTCTcttctccccttccatttctgccttttgttc GACTTCCTGATTGCT-TTCTCTCTCGTCCTTCCATTTCTTCCTTCCTTCC GACTTCCTGATTGCT-TTCTCTTTTGTCCTTCCATTTCTTCCTTCC---- GACTTCCTGATTGGT-TTCTcttctgtccttccatctctgccttctttca GACTTCCTGACCATTCTTTTTTTCTTCCCTTCTGTTTCTCCTTTCC---- ********** * ** * * ***** * *** * ** 1500 atttcatcctttcacttctttcccttcctccatcctcctccttcctagtt ATTTCATGCTTTCATTTCTT--------------CCCCTAGCTTCTAGTT ATTTCATGTTTTCATTTCTT--------------CCCCTAGCTTCTAGTT t--ccatcctttcatttctt--------cccctcctcgttcatcc----- TTTACA-------AACTCTTT----------------------------T ** * **** 1550 catcccttctcttccAGGCAGCCGCGGTG-----------CCCAACCACA GTTTCTT-CTGTTCCAGGCAGCTGCAGTG-----------CTGAACCACA GTTTCT----GTTCCAGGCAGCTGCAGTG-----------CCCAACCACA -----cttcTGTACCAGGCACCCACAGTT-----------CCAAGCTTTA GCCCCCT----CTCTAGGCATCAGCAGTGAGTGCTCTCAATTTAGTTGCA * ***** * * ** * * 1600 CTT-----------------GTCGGCTCCAGTCCCCAGAACTCT--GCCT TGGTTACCTAAC----AGCAGTCAGCTGCAG-CCCTAGGATTCT--TCCT TGCTTACCTGAC----AGCAGTCAGCTGCAG-TCCTAGGATTCT--CTCT CCT-GAGCTGAT----GCTGGTCAGCTCAGGCCCCCAGATCTCA--CCCT CATTGAACTAACTGGCCCTTGTAGGCTCCTAGCTGGGTAATCCTAACCGA ** *** * 1650 GCCCTTTGTCCTCCTGCTGCCAGTACCAGCC-----CCACCCTGTTTTGA GCCCTTTAACTTCCCATTGCCAGTGCCAGGT-------ATCATATTTAA- GCCCTTTAACTTCCCAGTGCCAGTGCCAGGT-------ATCATGTTTAA- GCCCTTGGCCTTCCCACTGCCAGCCCTAGCCCCGACCCAGCCCATTCTGA GCCCTGGGACATGT--------ACACCTGGT-----CACTTACTTTCTTG ***** * * * * ** 1700 GCCCTGAGGAGGCCTTGGGCTCTGCTGAGTCCGAC-------------CT -CCTTGAGCAAGAGCTGGGCTCTTTTGAGCCCTCC-------------CT -CCTTGAGCAAGCGATGGGCTCTTCTGAGCCCTCC-------------CT GGCCTGAGGAAAACCCGGGCTCTGCTGAGTCCACCTGGCCCTAGCACCCT CCAGTAAGGAAAATC----ATTTGATGAATCTGGT-------------CA * ** * * * *** * * 1750 ----GGCCTGTCTGTGAAGAG---CAAGAGAGCAGCAAGGTC-------- ----AACCT--CTGTGAAGAAGAACAAGAAGGTAGGAAGCTC-------- ----AGCCT--CTGTGAAGAA---CAAGAAGGTAGGAAGCTC-------- ----GGCCT--CTCCGAAGGG---CAAGAGAGCAGCAAGATC-------- TAAGAGTTT-------GAGGC---CCAGCAAACACAAAAATCATAAACCT * ** * ** * ** ** 1800 --TTGCTCTCCTAGGTAGCCCCCTCTTCCCTGGTAAGAAAAA-GCAAAAG --TTGCTCT---------------------TGCTAAGAAAAATGTCAAAA --TTGCTCT---------------------TGCTAAGAAAAAAGTCAAAA --TTGCTCTCTGAGGGAGCTCCCTTCCC--TGG----------------- AGTTGCCCT--------GCCCTACCCCCCCCCAAAAAAAAAAA------- **** ** 1850 GCATTTCCCACCCTGAACAACGAGCCTTTTCACCCTTCTACTCTAGAGAA GGCTTTCAGACCTTAAACAATGAGCCTTTTCACCTT-TTACTCTAGAAAA GGCTTTCAGACCCTAAACAATAAGTCTTTTTACCTT-CTACTTTAGAAAA -----TCAGACCCTGGATTCTGGGCCTTCTCGACCTTCTATCCAAGAAAA ----------------------AGCCTTTCCAGGCTTTGATTACTTAGAA * *** * * * ** 1900 GTGGACTGGAGGAGCTGGGCCC--------GATTTGG------TAGTTGA GTGGACTAGAAAATCTGGGTCA--------CATTGGG------TAGCTGA GTGGACTAGAGCATCTGGGTCA--------CATGTGG------TAGCTCA GCAAGCAGGAGAAGTTGGACA---------GATTTGGATTTGGAAGCTGA GCAAA--AGAGAAGTTTAGAAAACCACTTCACTCTGA------GGCCTGC * ** * * * * * 1950 GGAAAGCACAGAGGCCTCCTGTGGCCTGCCAG------------------ AGGAGATACAGAGGCC-CCTATGGCCTGCCAGAG---------------- AGGAGATACAGAGGCC-CATATGGCCTGCCAGAA---------------- GGGTAGCACAGAGGCC-CCCATGGCCTGCCATAG---------------- CAGAGTGACAAAGGAATCCTTCTGCCTACCAAAGCGATGAAACAAACCTC *** *** * **** *** 2000 --TCATCGAGTGGCCCAACAGGGGCTCCATG---------CCAGCCGACC --TCGTTGCATGGCCCAACAGGGGCTCCATG---------CCCACTACCC --TCATTGCATGGCCCAACAGGGGCTCCAGG---------CCCATTACCC --TCACCGAGTAGCCCAGC------------------------CCTGACC CTTAGCCAAGTGG-ACAGCACAATCACAATGCTTTTTTCTCCTCTCCATT * * * ** * 2050 TTGACCTCACTCAGAAGTCCAG--AGTCTAGCGTAGTG-CAGCAGGGCAG TTGACCCTACTCAGAAATCTAA--TGTCATACTTAGTGTGGGCAGGGGAC TCAACCCTACTCAGAAGTCTAA--TGCCAAGCTTAGTGTGGGCAGGGTAC TTGACCTCGCC---AGGCCCAGCCAGCATAGTGCAGTG-CAATGGGGCGG TTGGCCTT--TCAAAGGTCACA--AGCTGGTCCTCTTA-GGGCACAG--- * ** * * * * * 2100 TAG-CGGTACCAA-TGCAGAA---CTCCCAAGACCCGAGCTGG-GACCAG CTGTCAGGACAGA-TGCAGAC-------------CTAAGCAGG-GAGTGA CTGTCAGGACAGA-TGGAGAC-------------CTGAGCATG-GAATGA CAGGTGGGAAGAAATGCAGAC---GCCCC-AGACCTGAGCTGG-GACGGG ----TGTTACAAA-TAAAGAGAACACTCCAAGATCTGGTCCATAATCTTG * * * *** * * 2150 TACCT--------GGGTCCCCAGCCCTTCCTCTGCT-------------- CACCA--------GGGCCCTTGGCCCTTCTTCTGAC-------------- CACCA--------GGGCCCCTGGCCCTTCTTCTGACGTGCGCGCGTGCGC CACCTAGACCCCTGGCCCCTCGGCTCCTCCTATAAG-------------- AGCCC--------AGCTCCCGGAGCACATACCTGCT-------------- ** * ** * 2200 ------------CCCCCTTTTCCCTC-------GGAGTTCTTCTTGAATG ------------AAACATACACATCC-------CAAGTCTTTTTCTAGTG GCACACACACACAGACACACACACACACACACACAAGTTTTTTTCTAGTG -------------------TTAACCA-------TGAGTTCTTTTCTGATG ------------CTTCCCACTTCCCA-------TGAGCTCTCCTCTGATG ** * * ** 2250 GCAA-TGTTTTGCTT-----TTGCTCGATGCAGACAG---GGGGCCAGAA GAAT-TCTTAACCTC-----TTGCTCACTGGGGACTGGGAAGCATCAGCA GGAT-TCTTAACCTC-----TTGCTCACTGGGGACTGGGCAGTGTCAGCA GAAAATGCCTGGCTT-----TTGCTTGCTGGAGACTGGGTGAGGCCAGCA GCAG-ATTTGGGCTTGAACCCTTTTTCAGAGAGGTTGAATAAGGCCATTT * * ** * * * * ** 2300 CACCACACATTTCACTGTCTGTCTGGTCCATAGCTGTGGTGTAGGGGCTT CATCCCATATTTCAAA----CTCTGCTCCATAAGTACAGTGGTGAATTTT CATCCCATATTTCAAC----CTCTGCTCCATAAGTATAGTGGTGAATTTT TATCACACATCTCCAC----ATCTGTGCCAGGGGAATGGTGTGGGGGCCG C---------TTCCAT----GTCTG------AATCTTGGTGGGAGG---- ** **** *** 2350 AGAGGCATGGGCTTGCTGTGGGTTTTTAATTGATCAGTTTTCATGT---- ATAGACTTGACTTTGCTGTGGGGTTTTAATTGGTCAGTTTTAATTT---- ATAAACTTGACTTTGCTGTGGGATTTTAATTGGTCAGTTTTCATTT---- AGAGGCTTGGGTTTGCTATGGG-TGTTCATTGATCAATCTCCACTT---- ----GGCAGGGCTTGC-------TTTCCATCTGCCTATTTTTTTTTTCAT * **** * * ** * * * * 2400 -----------GGGATCCCATCTTTTTAACCTCT------GTTCAGGAAG -----------GGGATCCCAAAGTTTTAACCTCC------ATTCAGGAAG -----------GGGAT---------TTAACCTCT------GTTCAGGAAG -----------AGGACCCCATCCTGTCATTCTGT------GTTCAGGAAG TTGTTTGGGGAAGGTTTATATCTTTTTAACCTTGCTGGGGGTTCAGGAAG ** * * ** ********* 2450 TGTTTAC (miR-30a-5p,miR-30c,miR-30d,miR-30b,miR-30e-5p) human/mouse/rat/dog/opossum TCCTTATCTAGCTGCATATCTTCATCATATTGGTATATCCTTTTCTGTGT TCCTTATCTAGCTGCATATCTTCATCATATTGGTATATCCTTTTCTGTGT TCCTTATCTAGCTGCATATCTTCATCATATTGGTATATCCTTTTCTGTGT TCCTTATCTAGCTGCATATCTTCATCATATTGGTATATCCTTTTCTGTGT TCCTTATCCTGCTGTATACCTTCATCATATTGGTATCTCCTTGTCTGTGT ******** **** *** ***************** ***** ******* 2500 TTACAGAGATGTCTCTTAT--ATCTAAATCTGTCCAACTGAGAAGTACCT TTACAGAGATGTCTCATATCTATCGAAATCTGTCTGA----GAAGTACCT TTACAGAGATGTCTCATATCTATCGAAATCTGTCTGACTGAGAAGTACCT TTACAGAGATGTCTCTTAT--ATCTAAATCTGTCCAACTGAGAAGTACCT TTACAGAGATGTCTCTTGT--ATAGAAATCTATCAAACTGCGAAGCACCT *************** * * ** ****** ** * **** **** 2550 AGTCTTA (miR-499) human/mouse/rat/dog TATCAAAGTAGCAAA-TGAGACAGCAGTCTTATGCTTCCAGAAACACCCA TATCAAAGTAGCAAA-TGAGACAGCAGTCTTATGCTTCCAGAAACACCCA TATCAAAGTAGCAAA-TGAGACAGCAGTCTTACGCTTCCAGAAACACCCA TATCAAAGTAGCAAA-TGAGACAGCAGTCTTATGCTTCCAGAAACACCCA TATCAAACAGTTAAAATGAGAGCGCAGCTTTCTGCTTCTacacacactca ******* *** ***** **** ** ***** * * **** ** 2600 CAGGCATGTCC--------------CATGTGAGCTGCTGCCATGAACTGT CAGGCACGTCC--------------CATGTGAGCTGCTGCCATGAACTGT CAGGCACGTCC--------------CATGTGAGCTGCTGCCATGAACTGT CAAGCACGTCC--------------CATGCGAGCTGCTGCCATGAACTGT catacatgcacacacacatataATACATGTGAGCTGCTGCAGTGAACTGT ** ** * * **** ********** ******** 2650 CAAGTGTGTGTTGTCTTGTGTATTTC-AGTTATTGT-CCCTGGCTTCCTT CGAGTGTGTATTGTCTTGTGTATTTT-CGTTAACGTTCCCCAGCTTCCTT CAAGTGTGTGTTGTCTTGTGTATTTT-CACTAACGTTCCCCAGCTTCCTT CAAGTGCGTGTTGTCTCGTGTATTTC-AGTTATTGTCCCCTGGCTTCCTT CAAATATGTGCCATCTAGTCTCTTTCCAGTCATTATTCCCCAGCTTCCTT * * * ** *** ** * *** * * *** ******** 2700 AGCACTT (miR-93,miR-302a,miR-302b,miR-302c,miR-302d,miR-372,miR-373,miR-520e,miR-520a,miR-526b*,miR-520b,miR-520c,miR-520d) human/mouse/rat/dog ACTATGGTGTAATCATGAAGGAGTGAAACATCATAGAAACTGTCTAGCAC CCTGCGGTGTAATCATGGAAGAGTGAAACATCATAGAAATCGTCTAGCAC CCTGCGGTGTAATCATGGAAGAGTGAAACATCATAGAATTCGTCTAGCAC ATTGCGGTGTAACCATGAAGGAGTGAAACATCCTAAAAACCGTCTAGCAC AGGAGGATGTAACCACAAAGGATCGAACTATTATCAAAATTATATTGCAT * ***** ** * ** *** ** * ** * * *** 2750 TTCCTTG-CCAGTCTTTAGTGATCAGGAACCATAGTTGACAGTTCCAATC TTCCTGG-CCAGTCCTTAGTGATCAGGAACCGTAGTTGACAGTTCCAATT TTCCTGG-CCAGTCTTTAGTGATCAGGAACCGTAGTTGACAGTTCGAATT TTCCTTG-CCAGTCCTTAGTGATCAGGAACCATAGTTGACAGTTCCAATC TTTCTTGATTAATCTTTGGTAACCAGGAACCATAGTTGACAGTTCCAATC ** ** * * ** ** ** * ******** ************* *** 2800 AGTAGCTTAAGAAAAA----ACCGTGTTTGTCTCTTCTGGAATGGTT--A GATAGCTTAAGATAAA----ACCATGTTTGTCTCTTATGGAATGGTT--A GATAGCTTAAGATACA----ACCATGTTTGTCTCTTATGGAATGGTTTTA AGTAGCTTAAGAAAAAAAAAAACGCGTTTGTCTCTTCCGGAATGGTT--A AGTA----------------AC-----------------------TT--C ** * ** 2850 GAA----GTGAGGGAGTTTGCCC---C-GTTCTGTTTGTAGAGTCTCATA GAACTAAGTGAGAGATCTTGCCC---C-ATTCTGTTTGCCGAATC--ATA GAACTAAGTGAGAGATCTTGCCC---C-ATTCTGTTTGCCGAATC--ATA GAA----GCAAGGGAGTTTGCCC---CCATTCTGTTTGCAGAATC--ATA CAA-------AGGGAGTTTGTCCTTTC-GGTCTTTCTGCAG------TTG ** ** ** *** ** * *** * ** * * 2900 GTTGGACTTTCTAGCATATATGTGTCCATTTCCTTATGCTGTAAAAGCAA GTTGGACTTT-TAGTGTATTTGTATCCATTTCCTTGTGCTATAAAAGCAA GCTGGACTTTCTAGTGTATTTGTATCCATTTCCTTGTGCTATAAAAGCAA GTTGGCCTTTGTAGCATTTTTGTACCCATTTCCTTATGCTGCAAAAGCAA TTCAGCCTTT--AGTAGATTTGTCTCAATTT------GCTGAACATCATA * **** ** * *** * **** *** * * * 2950 GTCCTGCAACCAAA--CTCCCATCAGCCCAATCCCTGATCCCTGATCCCT ACCCTGCAACCAGC--TTTCTGTCAGGC----------------AGTCCT ACCCTGCAACCAGC--TTTCTGTCAGGC----------------AATCCT GTCCCACA-CCAG------------------------------------- GGACTACCACAAAAAACTCTCATTGGTCCC--------------AGCCCT * * * * 3000 TCCACCTGCTCTGCTGATGACCCCCCCAGCTTCACTTCTGACTCTTCCCC TTTGCCTGCTCTGCTTTTGATCCTCTTAGTCTTGCTTCTGGTTCCTCCCT TTTGCCTGCTCTGCTTTTGATCCTCTTAGTCTTGCTTCTGATTCCTCCCT ---ACCTGCTCTGCTGTTGACCCTCTGGGCTTCACTGCTGACTCCTCCCC TAGGCCCTTACCACTTTTCAATCTTCCTGCTTCACTGCTGATAACACCCC ** * ** * * * * * ** *** *** 3050 AGGAAGGGAA-GGGGG----------GTCAGA-----------AGAG--- GGAGAGGGAG-GAGGG----------GTCAGAAGAGGAATTCTGGAGGAT GGAGAGGGAG-GAGGG----------GTTGGAAGAGGAACTCTGGAGGGT AGGAAAGGAAAGGGGG----------GTCGGA-----------GGAG--- CCCAAAGGGA-GGGGGTTTATGGGTTGTCCTA-----------GGAG--- * ** * *** ** * *** 3100 --AGGGTGAGTCCTCCAGAACTC----TTCCTCC------AAGGACAGAA CCAGGATATGTCCTTCTGAACTCCTGCTTCTTCC------AGTGACAAAA CCAGGATATGTCCTTCTGAACTCCTGCTTCTTCC------AATGACAAAA --GGGGCGAGTCCTTCAGGACCCCTC-TTCCTTC------AAGGACAAAA --GGTGTAATTCCTTTGTAGCACCTC-TTCCACCTTCTCTAAGGAGAAAC * **** * * *** * * ** * * 3150 GGCTCCTGCC--CCCATAGTGGCCTCGAACTCCTG--------------- GGCCCCTACTGCCCCACCCCAACCT---GCCCCAT--------------- GGCCCCTGCAACCCCACCCCAACCT---GCCCCAT--------------- GGCTCCTGAC--CCCAAAGTGGCCTGTCACTCCTG--------------- GGCTCCCAAG--CCTACCACGTCTCCTCGCTCTGGATTTGTGTGTTCCTT *** ** ** * * * * 3200 -----------------------------GCACTACCAAAGGACACTTAT -----------------------------GCACTCCTCTAGGACACCTTT -----------------------------GCACTCTTCAAGGACACTTTT -----------------------------GCACCCACAAAGGATGCCTAG AAGTCCTTTTTTAATGGTGGATTTCTAATGGGCCTCCAGAGGACA----C * * **** 3250 CCACGAGAGC-GCAGCATCCGACCAGGTT--------------GTCACTG CCATACTTTTCACAACACCTAGCCAGGTT--------------GACACC- CCATACCCTT-ATAGCACCTAGCCAGGTT--------------GACACC- CCACACGAGT-ACAGTGTCCGGCCAGTTT--------------GCCATGG CCACATGTGC-ACTTTAACTAGTCTGTTTCTTGAAGCCCCTTTATCATTG *** * * * ** ** 3300 AGAAGATGTTTATT--------TTGGTCAGTTGGGTTTTTATGTATTATA --AAGTTGTTTATTG-------TGGTCTGCTTGGAATTTTACCTGTTAGG --AAGTTGTCTATTG-------TGGTTTGCTTGGGATTTTGCCTGTTATG AGACACCGGCCGTT--------TTGGTCTGTTGGGTTTTTATCCATTACA GAAAGGGATATTTTTAGTGTTTTGGTTTGGTTTGGTTTTTGCTTGTTATA * ** * * ** * **** *** 3350 CTT-----------AGTCAAATGTAATGTGGCTTCTGGAATCATTGTCCA CTTA-------CTTAGTCCAATCAAATG-GACTCC--------------- CTTA-------CTTAGTCCAATAAAATG-GACTCCT-------------- CTT-----------AGCCCAATGGAATGTGACTCCCGGAACCGGTGTCAA CTTCAAGTATTCTTAGACTAGTAGAATTGAGCTCTTGGGACCATCATCAG *** ** * * * *** ** 3400 GAGCTG-CTTCCCCGTCACCTGGGCGTC-------ATCTGGT--CCTGGT -AAGT---------------TGGGTATC--------CCTCAT--CTTTGG -AAGT---------------TGGGGATC--------CCTCAT--CCTTGG GAGCTGGCCTCTCCATAAGCTCAGTACC-------ATCTGGT--CCTGGG GGAAGG---------ATAGTTCAGTGTTTCACCCTATCTGATTCCCTGGA * * ** * * * * 3450 AAGAGGAGTGCGTGG-CCCACCAGGCCCCC------------CTGTCACC AAGA------------CAACCTAGGCTGAT------------TAGATATT AAGA------------CAACCTAGATTGAT------------TAGACATT AAGAGGAGTGCAGGG-CCCTCCATGCCCCC------------CTTTCACC AAGAGGAGTCTCTGGTCCCCACAGAGTCCCATTGGACTCTTTCTGACGCA **** * * 3500 CATGACAGTTCATTCAGGG-CCGATGGGGCAGTCGTGGTTGGGAACACAG TACTT---------------------------------TTGGGATTGCAG TACAG---------------------------------TTGGGATCGAAG TGTGACC----ATTCAGGGGCTGACCGGGCATTGGTGGTTGAGCACATC- CGCTTCACCTCATTCAAGGGTATTTTAGACAGGGGAGGT-------ACAG * 3550 CATTTCAA---GCGTCACTTT-ATTTCATTCGGGCCCCAC-CTGCAGCTC CACTTTGG---GTGCCGTTTTTCTTTTACTTGGGTTTTAT-CTGCAGCTC CACTTTGG---GTGCCATTTT-CTTTTATTTGGGCTTTAT-CTACAGCCC -ATTTCAA---GTGTCATTTT-CTCTCGGCCTGTCCTGAC-CTGCAGCCC CACTTGAAAATGAGAATCTTT-CCTCTGGATGAGTCAAATTCTGCAGCCC * ** * * *** * ** **** * 3600 CCTCAAAGAGGCAGTT-----------GCCCAGCCTCTTTCCCTTC-CAG CCTC---------ACCACCACCACCACCCCCCACTTACCTGTATGTAGAA CCTC---------ACT-----------CCCCCACTTTCCTGTATGTAGAA CT------------------------------------------------ CCCT---------AC------------CTCCCTCTTCCTTCACT---GAA * 3650 TTTATTCCAGAGCTGCCAGTGGGG---CCTGAGGCTCCTTAGG------- CTGATTTCAAAACTGCAGGTGGTGGTAACTGCAGCTTCTTAGG------- CTGATTTCAAAACTGCAGGTGGTGGTACCTGCAGCTCCTTAGG------- ------------------------------GAGGCTCCATAGG------- ATG--TCTAAAGCTGCAGGTGGTG---ACCAGGGCTCTTTACATTTCTGG *** ** 3700 -------GTTTTCTCTCTATTTCCCCCTTTCTTCCTCATTCCCTCGTCTT -------GTTTTCTT--CACTTCTTGCTTCTTTCCCCATTCCCTCATC-- -------GATTTCTT--CACTTCCTCCTTCTTTCCCCATTCCCTCATC-- -------GTTTTCTCTCC-TTACGCCCTTTCTTCCACATTCCCTCTTC-- TGGTTTTGTTTTTCCTCCTCCTCCTCTTTCTTCCAACCTTTCCTCTCCTC * *** * ** * * * ** **** * 3750 TCCCA---AA----GGCATCACGAGTCAGTCGCCTTTCAGCAGGCAGCCT -CACA---AATAAGGGCATCACAAGTCAGTCTCCTTTAAGCAGGCAGCTT -CACA---AA-----------CTAGTCAGTCTCCTTTAAGCAGGCAGCTT -TTCACCTAATAAAGGCATCACAAGTAAGTCACCATTAAGCAGGTCGCCT CCGCA---GCCAGAAGGGGCCTGAGTCAGGCCCCCTTCAGGAGACT---- ** *** ** * ** ** ** ** 3800 TG-GCGGTTTATCGC--CCTGGCAGGCAGGGGCCCTGC------AGCTCT TGGTGGGGTTTTTCC--CCTGGAAGCCAGGGACCCTGT------------ TGGTGGGGTTTTTCC--CCTGGAAGCCAGGGACCCTGTATAGCTAGCTCT TG-GTGGTTTGTTCC--CCTGGCAGGCAGGGGCTCTGC------AGCTGC ---GAGATTTCTCCCTCCCTTGAAGG----------GC------AGTTGG * ** * * *** * ** * 3850 CATGCTGCCCCTGCCTTGGGGTCAGGTTGACAGGAGGTTGGAGGGAAA-G CAGGCTGCCTCTGCCTTGTGGTCAGGTTGACAGGAGGTTGGAGGGAAAAG CAGGCTGCCTCTGCCTTGCAGTCAGGTTGACGGAAGGTTGGAGGGAAAAG CGTGCCACCCGTGTCCTGG-GTCGGGTTGACAGGAGTTTGGAGTGAAA-G CATGGTCTCCTTGCATTTATTT----TTCACCGTGGCTCAAA----AA-T * * * ** * * ** ** * * * * ** 3900 CCTTA---AGCTGCAGGATTCTCA-CCAGCTGTGTCC----GGCCCAGT- CCTTA---AGTCATGGGATTCTCA-CCAGCTGTGTCT----GGCTCAGA- CCTTATTAAGTCATGGGATTCTTAACCAGCTATGTCT----GGCTCAAA- CCA-----GGCAGTGGGGTTCTCA-CCAGCTGTATCC----AGCCCAGT- TCTCTCC-AGCTGTGGGGTACTTT-CCATCTTTTGCTCTGAGGCCCAGTG * * ** * ** *** ** * * ** ** 3950 -----TTTGGGGTGTGACCTCAATTTCAATTTTGTCTGTACTTGAACATT -----CCTGGAATGTGACCTTTATTT------TGT-TGTATTTGAACATT -----CCTGGAGTGTGACCTTTATTT------TGT-TGTATTTGAACATT -----TTGGGGGTGTGACCTCGATTT------TGTGTGTACTTGAACATC TCACATCTGGGAAATGAGCToooooooooooooooooooooooooooooo ** *** ** 4000 ATGAAGAT---GGGGGCCTCTTTCAGTGAATTTGTGAACAGCA---GAAT GTAAAGTGT-GGGTGGTACCTTAAACTGAATATGTGAAGAATCCAGAAAC GTAAAGTAT-GGGTGGTATCTTTCGCTGAATATGTGAAGAATACAGAAAC ACGAAGAT--GGCGGGCATCTTTTAGGGACTGTGTGAAGAATATAGAAAT oooooooooooooooooooooooooooooooooooooooooooooooooo 4050 TAGGTCA (miR-192,miR-215) human/mouse/rat/dog TGACCG-ACAGCTTTCCAGTACCCATGGGGCTAGGTCATTAAGGCCACAT TGACCA-ACAGCTTTCAGATACC--TGGGGCTAGGTCACTAAGGTCACAT TGACCA-ACAGCTTTCAGATACC--TGGGGCTAGGTCACTAAGGTCACAT TGACCC-ACAGCTCTCAGACACCTGTTCGCCTAGGTCAC-ACAGTCCCTT oooooooooooooooooooooooooooooooooooooooooooooooooo 4100 ACTACCT (miR-196a,miR-196b) human/mouse/rat/dog CTACCTC (let-7a,let-7b,let-7c,let-7d,let-7e,let-7f,miR-98,let-7g,let-7i) human/mouse/rat/dog CCACAGTCTCCCCCACCCTTGTTCCAGTTGTTAGTTACTACCTCCTCTCC C--CAGTCTTCCCTACCCT-GTTCTAGTTGTTAGCTACTACCTCTCC--C C--CAGTCTTCCCTACCCT-CTTCTAGTTGTTAGTTACTACCTCTCC--C T--CAGTCTCTCCAGCCCTCGTTCTAGTTGGTAGTCACTACCTCCTCTCC oooooooooooooooooooooooooooooooooooooooooooooooooo 4150 TGACAA--TACTGTATGTCGTCGAGCTCCCCCCAGGTCTACCCCTCCCGG AGATAGATTGCTGTATATCCTCCAACTATGATCAT-----CCTGGCCCAA AGATAGATTGCTGTATATCCTCCAACTATGATCAT-----CCTGGCCCAA CAACAGAATGCTGTATGTCCTCGAGCTCCTCTCAC-AATGCCCTGCTCTG oooooooooooooooooooooooooooooooooooooooooooooooooo 4200 C-CC---TGCCTGCTGGTGGGCTTGTCATAGCCAGTGGGATTGCCGGTCT G-CT---TGCCTGTTCTTGAGTCTGTCTTAACCAGTGGAACTGCTGCCCT G-CT---TGCCCATTCTTGAGTCTGTCTTAACCAGTGGAACTGCTGCCCT C-CC---TGCCCATTGGTGGGCCTGCCCTAACCAGTGCAGTTGCTGGCCT oooooooooooooooooooooooooooooooooooooooooooooooooo 4250 T-GACAGCTCAGTGAGCTGGAGATACTTGGTCACAGCCAGGCGCTA---G T-GGT-GTGCAGTGAGTTGAGGACTCTTGGTCACAGCCAGGCTCTAGTAG T-GAT-GTGCAGTGAGTTGAGGACTCTTGGTCACAGCCAGGATGTAGTAG T-GACATGGCAGTGAATCAGGGCAC-TAAGCCACAGCCAGGCTCTC---A oooooooooooooooooooooooooooooooooooooooooooooooooo 4300 CACAGCTCCCTTCTGTTGAT---GCTGTATTCCCATATCAAAAGACACAG TACAGCTCCTTTCTGCTGGT---GCTGTATTTCCATATCAAAAGGCACAG TACAGCTCCTTTCTGCTGGT---GCTGTATTTCCATATCAAAAGGCACAG GACCGCTCCCTTCTGCTGCTGCTGCTGCATTCCCGTGTCAGAAGGCACAG oooooooooooooooooooooooooooooooooooooooooooooooooo 4350 GTGCCAA (miR-96) human/mouse/rat/dog GGGACACCCAGAAACGCCACATCCCCCAATCCATCAGTGCCAAACTAGCC GGGAGATCTAGAAATGCCATCTCCCCCAGTCCATCAGTGCCAAACAAGCC GGGAGATCTAGAAATACCATCTCCGTCAGTCCATCAGTGCCAAACAAGCC GCGACACCTAGAAATGCCCCGTTCCCCAGTCCATCAGTGCCAAACTACCC oooooooooooooooooooooooooooooooooooooooooooooooooo 4400 AACGGCCCCAGCTTC-TCAGCTCGCTGGATGGCGGAAGC----------- CATGATCCCAGCAT------------------------------------ CATGATCCCAGCAT------------------------------------ AAGGACCTCAGCCCCCTCCACTCCCTGGAAGGTGAAAGCCATGGTGGCGG oooooooooooooooooooooooooooooooooooooooooooooooooo 4450 --------------------------------TGCTACTCGTGAGCGCCA -------------------------------------------------- -------------------------------------------------- CCCAGCAACACTGGCTACAGTCAGCACCTGGCTTCTACCCTTGAGGTCCC oooooooooooooooooooooooooooooooooooooooooooooooooo 4500 GTGCGGGTGCAGACAATCTTCTGTTGGGTGGCATCATTCCAGGCCCGAAG ----GGGTACAGACAAC--TCTGTTCAGTGCTATCACAACAGACTAGAGG ----GGGTACAGACAAT--TCTGTTCAGTGCTATCACAACAGACTAGAGG ATGCAGGTGCGGGCAACA--CTGTTCAGGGGCACCATTCCAGGTGAGAGG oooooooooooooooooooooooooooooooooooooooooooooooooo 4550 C-ATGAACAGTGCACCTGGGACAGGGAGCAGCCCCAAATTGTCACCTGCT CCATGAACATTGGACGTGGGAACCAGAGCAACCC-GAATTG----CTGCT CCATGAACATTGGATGTGGGAACCAGAGCAACCG-AAATTG----CTGCT CCACAGACTGTGGCACCAGCACCCAGAGCAGCCCCAAGTTGTTCCCTGTC oooooooooooooooooooooooooooooooooooooooooooooooooo 4600 CAGCTTT (miR-320) human/mouse/rat/dog TCTCTGCCCAGCTTTTCATTGCTGTGACAGTGATGGCGAAAGAGGGTAAT GCTTTATTCAGCTTTCCGTTGCTCTGACAATGATA---AAACAAGGCAGT GCTTTACTCAGCTTTCTGTTGCTCTGGCAGTGATG---AAACAAAGCAGT CCTCTGCCCAGCTTTTCATTGCTGTGATGGGGATCATGAAAGAAGGGACT oooooooooooooooooooooooooooooooooooooooooooooooooo 4650 ----AACCAGACACAAACTGCCAAGTTGGGTGGAGAAAGGAGTTTCTTTA ----AACTTAAAACAGACTGCCAGGTTTGGCAGAGAAAGGAAATTCCTTA ----AACCAGAAACAGACTGCCAGGTTTGGCAGGGAAAGGAATTTCCTTA ----AGCCTGAAACAAACTGCCATGTTTGATGGGGAA-GGAGTTTCTTTA oooooooooooooooooooooooooooooooooooooooooooooooooo 4700 GCTGACAGAATCTCTGAATTTTAAATCACTT--AGTAAGCGGCTCAAGCC GCTGACAGCACCTCTGGATTTTAAATAGGTTGTAATAAGTGGCTCAAACC GCTGACAGGACCTCTGGATTTTAAATAAGTTGTAATAAGTGGATTAAACC GCTGACAGGACCTCTGGATCT-AAGTAACTT--AATAAGCAGCCGAAGCG oooooooooooooooooooooooooooooooooooooooooooooooooo 4750 CA----GGAGGGA-GCAGAGGGATACGAGCGGAGTCCCCTGCGCGGGACC CATCCAGGAAAAA-GCAAAAGGGTTAGAACTGA-----CCAGATGAGACC CATCCAGGAAAAAAGCAAAAGAGTTGGAACTGA-----CCAGATAAGACC CA----TGAGGGA-GCAGAAGG-TATGACGTGAACTCACCAGGTGGGGCC oooooooooooooooooooooooooooooooooooooooooooooooooo 4800 ATCTGGAATTGGTTTAGCCCAAGTGGAGCCTGACAGCCAGAACTCTGTGT AGCCTGATTTCATGCAGCCCAAATGGAGTCCAGCTGTCTGAACTCTGCAG AGCCAGATTTCATGCAGCCCAAGTGGAGTCCAGCTGTCTGAACTCTGCAG CACTGGATCTTGCAGAGCCGAAGTGGGGCCTGGCAGCC-GAGCTCTGT-- oooooooooooooooooooooooooooooooooooooooooooooooooo 4850 CCCCCGTCTAACCACAGCTCCTTTTCCAGAGCATT-CCAGTCAGGCTCTC CACTTCTCTA-CTACAGTCTCCT----AGAGCATT-CCAGCCAGGCTCTT AACTTCTCTAACTACAGTCTCCTT-CCAGAGCATT-CCAGCTAGGCTCTT ----------------GCCCCATTTCCAGAGCATTTCCTTCCAG-CTCTC oooooooooooooooooooooooooooooooooooooooooooooooooo 4900 TGGGCTGACTGGGCCAGGGGAGGTTACAGGT-ACCAGTTCTTTAAGAAGA CAGGCTGA--------GGAGACATCACAGGT-GCCAGTTCTTCAAGAAGA AAGGCTGA--------GGAGGCATCACAGGT-GCCAGTTCTTCAAGAAGA TGGGCTGATGGAGCCAGGGAGGGTCACAGGT-GCCGGT-CTTGGAGAAGC oooooooooooooooooooooooooooooooooooooooooooooooooo 4950 TCTTTGGGCATATACATTTTTAGCCTGTGTCATTGCCCCAAATGGATTCC CTTTTGTGCATC--AGTTCATAGCCTATATCTTTGCCCAAGATTGTA--- CCTT-GTACATC--AGTTGGTAGCCTATAACTTTACCCTGGATTGTTTGT CTTTTTCACCTC--CTTTCCCAGCCAGT-----AGCCCCAAATTGTTGTT oooooooooooooooooooooooooooooooooooooooooooooooooo 5000 ---TGTTTCAAGTTCACACCTGCAGATTCTAGGACCTGTGTCCTAGACTT ----GATTCAGGTTAACAC-TACAGATTCTAGGGCAGATGACTGAGACT- ---TGATTCAGGTTAACAC-TACAGATTCTAGGGCGGATGACTGAGACT- CCCTGATGGGAGTT-TTACGCACAGATTTTAGGACTGATGGCCCGGACCT oooooooooooooooooooooooooooooooooooooooooooooooooo 5050 CAGG-GAGTCAGCTGTTTCTA-GAGTTC-------------------CTA CAGA-AA-AAA------------AGCCC-------------------CTG CAGA-AA-AAAGCAGTTTCTA-AAGTTC-------------------CTG CAGG-AAGCAAGCTGTGTCTAAGAGCCC--TGTGGGCGTTTGCGTAGCCA oooooooooooooooooooooooooooooooooooooooooooooooooo 5100 --CCATGGAGT-------------G------------------------- -----TGGACT-------------GTGGTATAGCGAAGTACAAAAACTGA -----TGGAGT-------------GTGG---------------------- GATCCCAGAGTCC---GGGCTCATG------------------------- oooooooooooooooooooooooooooooooooooooooooooooooooo 5150 ---GGTCTGGAGGA-----------------------CCTGCCCGGTGGG AGGGGGCTAGGGCAG----------------ATGCCGCATGCCTCATGCC ---GGACTAGGGCAG----------------ATGCAGCATGCCCCATGCC ---GTGTTGGGGGCGGGGGGCAAGCATGGCAGCGTCGCCCAGCCTGTGGT oooooooooooooooooooooooooooooooooooooooooooooooooo 5200 GGGG----------------CAGAGCCC-T--GCTCCCTCCGGGTC---- AGAG----------------CCAAGCCC-TCTGCTCCATCCACATCC--- TGAG----------------CCAAGCCC-TCTCCTCCATCCACATCC--- AGAG-------CCCCGC-TCCCGTGCCCCTGTGGCCCCACCATGTCG--- oooooooooooooooooooooooooooooooooooooooooooooooooo 5250 ------------------------------------T------------- --------TTTTCTGGC-------------TCCTTCT------------- --------TTTTCTGGC-------------TCTTTCT------------- --------CGTTCCTGC-------------TCTTACTCTGTCCTCTGTAA oooooooooooooooooooooooooooooooooooooooooooooooooo 5300 ---TCCT-------ACTCTTCTCT--------------CTGCTCTGACGG ---TCCT-------GCTCTCTGCTTCAGTGAACCAGCCCCACTCTGAAGA ---TCCC-------GCTCTCTGCTTCAGCAAACCAGCCCCACTCTGAAGA GGGCCCCCACCTTTGCTCTCTTCATCAGTAAACTCGT-CCACTCTGGAGG oooooooooooooooooooooooooooooooooooooooooCTTTAACAG ** * 5350 GATTTGTTGATTCTCTCCATTTTGGTGTCT--TTCTCTTTTAGATA---- GATTTGTTGATTCTCTCCATTTTTATGTCT--TTCTCTTTTAGGTA---- GATTTGTTGATTCTCTCCATTTTTATGTCT--TTCTCTTTTAGGTA---- GGTTTGTTGAGTCTC--CATTTTTGCGTCT--TTGTCTTTTAGATA---- AATTCATTGAATGTCTCCATTTGTATATTTGTTTCTCTTTTCAAAGAGTG ** **** * ** ***** * * ** ****** 5400 ---TTGTATCAATCTTTAGAAAAGGCATAGTCTACTTGTTATAAATCGTT ---CTATAT--------AGAAAAGGCTTAGTCTAATTGTTATAAATTGCT ---CTATAT--------AGAAAAGGCTTAGTCTAATTGTTATAAATTGCT ---CCGTATCAATCTTTAGAAAAGGCATAGTCTAATTGTTATATATAGCT TCCTTGTACCATTGTAAAGAAGGGCATTTGCCTGCTTGT-GGATTTTACT ** **** * * * ** **** * * * 5450 ACTGCCT (miR-34b) human/mouse/rat/dog CAGGGTC (miR-504) human/mouse/rat/dog ------------------AGGATACTGCCT--------CCCCCAGGGTCT ------------------AGAATACTGCCT--------CCCCCAGGGTCT ------------------AGAATACTGCCT--------CCCCCAGGGTCT ------------------AGGATACTGCCT--------CCCCCAGGGTCT CCTCCTGGGGAAGGAGGGATGGTTTTGCTTTTGGTGTTCACTCCTGGCCT * * *** * * * * ** ** 5500 AAAATTACATATTAGAGGGGAAAAGC--TGAACACTGAAGTCAGTTCTCA AAAAATATATGCTAAAGGGGAAAACT--TGAACACTGAAACCAGTTCTGA AAAATTATATGCTAAAGGGGAAAACT--TGAATACCGAAACCAGTTCTGA CAAGTTACATATTAAAGAAGAAAAAAAGTGAACACTGAAACCCGTTCTCA AAT----CACATTTCAGAAAGTGTGC--TGTGTGCGTGCGTGCGTGCGTG * * * ** ** * ** * 5550 ACAATTTAGAAGGAAAACCTAGAAA-ACATTTGGCAGAAAATTA-----C ACAATTTAGAAGGAAAACCTTGAAA-ACATTTAACAAAAAATTA-----T ACAATTTAGAAGGAAAACCTTGAAAGAAAATTAACAAAAA-CTA-----C ACAATTCAGAAGGAAAACCTAGAAA-ACATTTGGCAGAAAATTA-----C TGCGTGAAGAGGAAATGAAATGTGA-ATGCCCGGCCCAAACCTAGAAACC * *** * ** * * * * *** ** 5600 ATTTCGATGTTTTTGAATGAATACGAG--CAAGCTTTTACAACAGTGCTG ATTTTAATGTTT----ATGAATAAGAG--GAGGCTTTTGAAAAAATGTTG ATTTTGATGTTT----ATGAATAAGAG--GAGACTTTTGAAAAAATGTTG ATTTCAATGTTTCTGAATGAATAAGAG--CAAGCTTTTGCAAAAATGCTG ATTTGGGTGTTTGTGAATGGACAAAAGGCCCAAATCTTGCTAAAGTCTTG **** ***** *** * * ** * ** * * * ** 5650 ATCTAAAAAT-------ACTTAGCACTTGGCCTGAGATGCCTGGTGAGCA ATCTATAAAT-------ACTTACT-TTAGGCCTGAGGTGTCTAATGAGTG ATCTATAAAT-------ACTTAAT-TTTGACCTGAGGTGTCTAATGAGTG ATCTAAAAAT-------ATTTGGAGTTTGGCCTGACATG--TGGTGAGTG GTCTAAACATCATTCGGAGTTAGAACTTATTATAAAGTGACAGCTGGACA **** * ** * ** * * * ** ** 5700 TTACAGGCAAGGGGA----------------------------------- AACTGAGCAATGGGAACTCAAGGCTGAAGCCTCCTGCATCAGAGGAGGTA ATTTGAGCAAAGGGA--------------------GCATCAGAGGAGATA GTACAGGAAAAGGGG-------------------------------AATC AAGTAGACAAAGGooooooooooooooooooooooooooooooooooooo ** ** 5750 -------------------------------------------------- GAACCAGGAGCCTCTTGAGATTTGAGGTGTT--------TTAGCATTGGA GAACCAGGAGCCTCTTGAAATTTGAAGTGTT--------TTAGCATTGGA CAGCCTGAAGCTGCTGG--------------------------------- oooooooooooooooooooooooooooooooooooooooooooooooooo 5800 ----------ATCTG--GAGGTAGCCG-ACCTGAGGACATGG-----CTT AAGCCA----CTCTT--TGGGTAGCTG-GCCCCAGAA-ACTA-----CTT AAGCCAATCGCTCTT--TGGGTAGCTG-ACCCCAGAATACCA-----CTT ----------ATCTG--AGACTCGGGG-CCATCCTAGCATTGGCGAGCCC oooooooooooooooooooooooooooooooooooooooooooooooooo 5850 CTGAACCTGT-----CTTTTGGGA-------------------------- CTGACCTTGT-----CATTTGGAA------TGGAGGT------------- CTGACCTTGT-----CATTTGGTA------TGGAGGT------------- CCTGTCCTGTGGGGCCGCCTGCCT----------GGTCCCC--------- oooooooooooooooooooooooooooooooooooooooooooooooooo 5900 ----GTGGTATGGAAGGTG------------------------------- --TAGTGGTCTGCCAGATGCCAAAGCTGCATGAGACCAGCTCTTGGTTTA --TAATGGTCTGCCAGATGCCAAAGTTACATGAGACTAGCTCTTGGTGCA -------------AAGCTG---------TAGGAGCCCAGCGCTTGGTGTG oooooooooooooooooooooooooooooooooooooooooooooooooo 5950 -------GAGCGTTCA-CCAGTGACCTGGAAGG----------------- TCAATTTGAACACTCA----GTAACCTAGAAGG----------------- TCAGTTCGAACACTCA----GTGACCTAGAAGG----------------- GGAAGT-AGCA--TCAACCAGTGGCTCCCAAGATCTGCGACGTTCTCACT oooooooooooooooooooooooooooooooooooooooooooooooooo 6000 -CCCAGCACCACCCTCC-TTCC--CACTCTTCTCATCTTGACAGAGCCTG -CCCAGCACAAAGTGTC-TGC---------TCTCTTCTTAACTGAGCCTG -CCCAGCACAAAGCGTC-TGC---------TCTCTTCTTAACTGAGCCTG ACCCAGCACCACCTGTTTCTTG--CTCCTTTCACATCTCGACAGGACATT oooooooooooooooooooooooooooooooooooooooooooooooooo 6050 CCCCA-GCGCTGACGTGT----------CAGGAA---------------- CCCCA-GCACTACTGCAC-------------------------------- CCCCA-GCACCAGTGCAC-------------------------------- CCCCAAGTGCTGATTTTTTTTTTTTTTTCGGGAAAAAGGGAGTTCTAACT oooooooooooooooooooooooooooooooooooooooooooooooooo 6100 AACACCCAGGGAACTAGGAAGGCACTTCTGCCTGAGGG-GCAGCCTGCCT ----------AAATTAGGGAGGGTCTACTTCCTACAGA-GCATCCCTCCC ----------AAATTAGGGGAGGTCTGCTTCCTATAGA-GCATCCCTCCC AGGGCCCAGGCAACTAGGAAGG----------TGAGGGTAAAGTCCCCCT oooooooooooooooooooooooooooooooooooooooooooooooooo 6150 TG--------CCCACTCC---------------TGCTCTGCTCGCCT--- TGGGCCCCC-TCCCATCCTTTG-----------TACTCTACCTACCT-GA TGGGGCC---TCCTGTCCCTTG-----------TACTCTACCTACCC-GA TTTGGCCTTTGCCGGTCCCCCGAGGACATCCCCTGCTCTGCTCTCCTAGG oooooooooooooooooooooooooooooooooooooooooooooooooo 6200 ---------------------CGGATCAGCTGAG---------------- CCTTCAGGATCTTGGCACATACGAAATGGCTGTGTAGCAAGCACTTTGGC CCTTTAGGATCTTGGTACATATGAAATGGCTGTGTGGCAAGCACTTTGGC GGCCCAGGGCCTGGG------TGAAGTGGTGCTC---------------- oooooooooooooooooooooooooooooooooooooooooooooooooo 6250 ----CCTTCTGAGCT------------------------GGCCTCTCAC- ATGCCCTCCTAAACTTA----------------CCCCAGAGCCTCTCCC- ATGCCCCCCTAAACTTA----------------CCCTAGAGTCTCTCCC- ----CCGTCTGCGCTCAGGGGTGAAGACAGAGGCCC---GAGCACTCAC- oooooooooooooooooooooooooooooooooooooooooooooooooo 6300 -----------TGCCTCCCCAAGGCCCCCTGCCTGCCCTGTCAGGAGGC- -----------TGCCTCCTTAAGCCAGTCTGCCTGTCTTCTGGGGAGGTG -----------TGCCTACTTAAGCCTGTCTCTCTGCTTTCTGAGGAGGTA ----.......TGTGTCCCCCTCGCCCCTCACCAGCG------------- oooo-------ooooooooooooooooooooooooooooooooooooooo 6350 ---------------------------AGAAGGAAGCAGGTGTGAGG--- TTAGAGCCCATAGAATGGAGAGGAGAAAGAAAAGAGGAAGAGGCAGGCAG TTAGAGTCCGTAGAGTGGAGAGGAAAAAGAAGACAGGAAGTGCCAGGCTA -------------------------------------------------- oooooooooooooooooooooooooooooooooooooooooooooooooo 6400 GCAGTGCAA--------GGAG-------GGAGCACAACCCCCAGCTCCCG GTAGTAAAAAGGCTCTGGGAG-------GAAAGACAGCCTCCTA------ GTAGTGAAAATGCTCTGGGAG-------GAAA-ACAGGCCCCTA------ AGAGCCCCTGGGCC---AGAG-------GGAGGGCAGGCACAAG------ oooooooooooooooooooooooooooooooooooooooooooooooooo 6450 CTCCGGGCTCCGACTTGTGCACAGGCAGAGCCCAG----------ACCCT -----------GGCTT-TGCACAAGCAGGACTCAG----------CCCCT -----------GGCTT-TGCACAAGCAGGACTCAG----------CCCCT -----------GAAGGGTGCT-GGGCAGAACCGAG----------ACCCT oooooooooooooooooooooooooooooooooooooooooooooooooo 6500 GGAGGAAA-----TCCTACCTTTGAATTCAAGAACATTTGGGGAATTTGG TGTGGGAACTAAGTGCCATCTTGGAGTTTAAGAACATTTGGACAAGTTGC CATGGGAACTAAGTGCCATCTTTGAGTTTAAGAACATTTGGACAATTTGC CACGAGGG-GAAGCCCGGCCTTTGAGTCTGAGAGCATTAGGGAAACCTGC oooooooooooooooooooooooooooooooooooooooooooooooooo 6550 AAATCTCTTTGCCCCCAAA---CCCCCATTCTGTCCTACCTTTAATCAGG AAATGACCTTTGCTCCTTG---CTCC-------TCTCACCTTTTATGGGG AAATGACCTTTGCTCCTTG---CTCC-------TCTCACCTTTTATCAGG AAATTGCCTTTGCTCCCCTAGCCCCCCCTCCTAGCTTACGTTTCCTCAGG oooooooooooooooooooooooooooooooooooooooooooooooooo 6600 TCCTGCTCAGCAGTGAGAGCAGATGAGGTGAAAAGGCCAAGAGGTTTGGC CCCTGCTTAGCACTGAAAGCAAATGCGCTGAAAAGGCAAAGAGGTTTGGC CCCTACTTAGCACTGAGAGCAAATGCGGTGAAAAGGTAAAGAAGTTTGGC TCCTCAGCAGCGA---GAGACAATGAGATGAAAAGGCCAAGAGGTTTGGC oooTGCTGCACGGCCAGAAGGCACAAGACAGAAAGCTGAGGAAATTCAGC * * * * * **** * ** ** ** 6650 CAGTGTT (miR-141,miR-200a) human/mouse/rat/dog TCCTGCCCACTGATAGCCCCT-CTCCCCGCAGTGTTTGTGTGTCAAGTGG TCCTGCCCACTGATAGTCCTT--TCCCTGCAGTGTTTGTGTGTCAAGTGG TCCTGCCCACTGATAGTCCTT-CTCCCTGCAGTGTTTGTGTGTCAAGTGG TCCTGCTCACTGCTAGTCCCT-CTCCTTTCAGTGTTTGTGTGTCCAGTGA TCCTGCCCGAAGGAAGGCCTTGATCCTCTGAGTGTC--TCTGTTAAGTGG ****** * * ** ** * *** ***** * *** **** 6700 CAAAGCTGTTCTTCCTGGTGAC---CCTGATTATATCCAGTAACACA-TA CAAAGCTGTTCTTCCTGGTGAC---TCTGATTAGATCCAGTAACTTAAGA CAAAGCTGTTCTTCCTGGTGAC---TCTGATTATATCTAGTAACTTA-GA CAAAGGTGTTCTTCCTGGTGAC---CCTGAGCATACCCAGTATCTTC-TA CAAAGCTCCTCTTCCTGGCAACGAAACCAACCCTATCCAG-AATACC-TA ***** * ********* ** * * * * ** * * 6750 GACT-GTGCGCATAGGCCTGCTT-TGTCTCCTCTATCCTGGGCTTTTGTT GATTTGTATGCATAGGTCTGCTT-TGACTCTTCTATTCTGGGCTTTTGAT GATT-GTATGCATTGGTCTGCTT-TGACTCTTCTATTCTGGGCTTTTGAT GACT-GTACGCGTAGGCCTGCTT-GGTCTCCTCTCTCCTGGGCTTTGATT GACT--CGAGCATAGGCCTGATTTTTCTCTCTTGATTCTGGGAT-----T ** * ** * ** *** ** * * ***** * * 6800 TTGCTTTTTAGTTTTGCTTTTAGT-TTTTCTGTCCCTTTTATTTAACGCA TTGTTTTTCAGTTTTGCTTTTAGT-TTTCCTAT---TTTTATTTTATGCA TTGTTTTTCAGTTTTGCTTTTAGT-TTTCCTGT---TTTTATTTTATGCA TTGCTTTTTAGCTTTGCTTTTAGT-TTCTCTGTCCCTTTTATTTAATGCA TTGTTTTTCAGTTTTAATCCTGTTCTTTTCCGTCCCTTTT-TTTAATGCA *** **** ** *** * * * ** * * **** *** * *** 6850 CCGACTAGACACACAAAGCAGTTGAATTTTTATATATATAT--------- CCAACTAGACACACAAAGCAGTTGAATTtatatatatatatatatatata CCAACTAGACACACAAAGCAGTTGAATTTATATATATATATATATATATA CCAACTAGACACACAGAGCAGTTGAATTTTTATATATATAT--------- CCGACTAGACGTAAAAAGCAGTCTAGTTTTTATATAT------------- ** ******* * * ****** * *** ******* 6900 CCACACA (miR-147) human/mouse/rat/dog ---CTGTATATTGCACAATTATAAACTCATTTTGCTTGTGGCTCCACACA tatctgtatatTTCACAATTATAAACTCATTTTGCTTGTGACGCCACACA TATCTGTATATTGCACAATTATAAACTCATTTTGCTTGTGGCGCCACACA ---CTGTATATTGCACAATTATAAACTCATTTTGCTTGTGGCTCCACACA ---CTGTATATTGCA---TTATAAACTCATTTTGCTTGTAGCTCCACA-- ********* ** ********************* * ***** 6950 CACAAAAA-AA----GACCTGTTAAAATTATACCTGTTGCTTAATTACAA CACACAAA-AAGAAAAACCTTTTAAAATTATACCTGTTGCTTAATTACAA CACAAAAA-AA-------CCTTTAAAATTATACCTGTTGCTTAATTACGA CACACACAAAA----GATCTGTTAAAATTATACCTGTTGCTTAATTACAA ----AAAA-AA----GGCCTGTTGGAATTATACCTGTTGCTTATTTACAA * * ** * ** ****************** **** * 7000 TCTGATA (miR-361) human/mouse/rat/dog TATTTCTGATAA-CCATAGCATAGGACAAGGGaaaa----taaaaaaaga TATTTCTGATAA-CCATAGAGTAGGACAAGGGAAAAAATTTaaaaagaaa TATTTCTGATAA-CCATAGAGTAGGACAAGGGAAAAATTTTAAAAAGAAA TATTTCTGATAA-CCATAGCATAGGACAAGGGaaaata--aaaaaacaaa TATTCCTGATTATCCATAGCCTAGGGCAAGGGAAAA----TAAAGGCGAA **** ***** * ****** **** ********** *** * 7050 aaaaaaagaaaaaaaaa-----------------------------CGAC aaaaaaaaaagaaaaa--------------------------------aC AAAAAA----GAAAAA--------------------------------AA aaaaaacaaaaacaaaaaaacacaaaaaaacaaaaaacaaaaaaaaCTAC AACAAAC---------------------------------------CTAC ** *** * 7100 AAATCTGTCTGCTGGTCACTTCTTCTGTCCAAGCAGATTC-GTGGTCTTT ACATCTGTCTGCTGGTCACTTCTTCAATCCAAGCAGATCT-GTGATCTTT ACATCTGTCTGCTGGTCATTTCTTCAGTCCAAGCAGATCT-GTGATCTTT AAACCTGTCTGCTGGTCACTTCTTCTGTCCAAGCAGATCC-GTGGTCTTT CACTCTGCCTGCTGGTCACTTTGTCTGTT-AAGCAGATCTTGGGGACTCT *** ********** ** ** * ******** * * ** * 7150 ----------------------------TCCTCGCTTCTTTCAAGGGCTT -----------------------------CCTCGCGTCTTTCAAAGACTT -----------------------------CCTTGCTTCTTTCAAAGGCTT -----------------------------CCTCGCTTCTCTCAAGGGCTT GCTTCAGtcctcctcctcctcctcctcctcctcctTTCTTTCCAGGGCTC *** *** ** * * ** 7200 TCCTGTGCCAGGTGAAGGAGGCTCCAGGCAGCACCCAGGT--------TT CCCTGTGCTAAGTGAAGGAAGCTCCAGGCTGCACCCAGGT--------TT CCCTGTGCTAAGTGAAGGAAGCTCCAAGCTGCACCCAGGT--------TT CCCTGTGCCAAGCGAAGGAGGCTCCAGACAGCATCCGGGT--------TT CCAGGGAGCTGGCTAAGTGAGCATCAGGGGCTTTCCCAATGGGAGCACTT * * * *** ** ** ** * ** 7250 TGCACTCTTGTTT-----CTCCCGTGCTTGTGAAAGAGGTCCCAAGG--- TGTGCT-TTGTTT-----CTCCTCTG-TTGTGAAAGGGGCCCCAAGA--- TGTGCT-TTGTTT-----CTACTCTG-TTGTGAAAGGGGCCCCAAAA--- TGCACT---GTTT-----CTCCCATGCTTGTGAGAGAGGTCCCAGGA--- GGTAGCTTTGTTTGGGGGTGGGGGTGGCAGAGGGAGGAACCCCAGGAGAT * **** ** * * ** **** 7300 -TTCTGGGTG----------------CAGGA------------------- -TTCTGGGTA----------------CAGGACAGTTCATTTCAGCATGGG -TTCTGGGTA----------------TAGGACAGCTCATTTCAGCATGGG -TGCTGG-TG----------------CAAGACAGTTCACCTCAACGGGTG GCCTTGGCTGTGTATCCCTGAAGATTCTGGACAGGCCCA----------- *** * ** 7350 --------------GCGCTCCCTTGACCTGCTGAAGTCCGGAACGTAGTC GTCAGGAGACAAGAGCACTCCCTTTACATGCTGACGTACAGAACTTAGTG TTTGGGAGACAAGAACACTCCCTTTACATGCTGAAGTCCAGAATTTAGTA GGTTGAAGA-----GCGCTTCCTTGCCCTGGCAAAGTCTGGAATGTAGTT --------------TTTCGCCCATTACCCAC---ATCCTGGGGCCCAGTT * ** * * * *** 7400 GGCACAGCCT-------GGTCGCC------TTCCACCTCT-------GGG GGAATAGCCT-------AGTC----------CCCACCTCTAGGGATGGGG GGCATAGCCT-------AATC----------CCCACCTCTAGGGATGGGG GGTACCACCT-------GGCCCCC------TTCGACCTCT-GGGTGGGGC GCCCAAGCCTTTTTTTTGGCCATTGTGGGATTTTGTTTCC-AACTGGGGG * *** * ** ** 7450 AGCTGGAGTCCACTGGGG-------TGGCCTGACTCC---CCCAGTCCCC AGCTAGCATGCATGGGGG-------TGACCCAACTCC---CTC---CACC AGCTAGCATGCATGGAGG-------TGGCCCAACTCC---CTC---CCCC AGCTGGAGTCCACGGGGGAGGGGGATGGCCTGACCCCACCCCCA--GCCC GG--GGGGGGCATCAAGG-------TATTCTGGCTTC---TCGT------ * * ** ** * * * * 7500 TTCCCGTGACCTGGT---------CAGGGTGAGCCCATGTGGAG--TCAG TTTCC-----CTGGC---------CAGGAAGAGCCTGTGTACAG--TAAG TTTCC-----CTGGC---------CAGGGAGAGCCTGTGTACAG--TAAG TCCCAGTGACCCAGT---------CACAGTGCTCATGTATGGAGAGTCAG -----GTGGCCTGATGTGTTCATTTATGACAGTTGTGAGTTGAGATGCAA * * * ** * 7550 CCTCGCAGGCCTCCCT--GCCAGTAGGGTCCGAGTGTGT---TTCA---- TCTGACAAGCTTTCCCCAGTTAGCAGGGCTC-AGAGCAT---TTAAA--- TGTGGCAGGCTTTCCCTAGTTAGCAGGACTC-AGAGCAT---TTCAA--- CTCAGCAGGCCTCCCC--ACCAGTAGGGCTT------------------- C-----AGGTCAATCG----TGGTAAGGTTT-AAAGCATAACCCCAACAG * * * * * * 7600 -------TCCTTCCCACTCT-----------------GTCGAGCCTGGGG -----AACCCTCCAAACTTT-----------------GCTGAGTCTAGGG -----AACCTTCAAGACTTT-----------------GCTGAATCCAGGA -------CC------ACTTG-----------------GCTGAGGCTGG-- CTGGGGAGCCTACCAGCTTTTCTCTGGACAGTATAAAGCCAACCCCATGG * ** * * * 7650 GCTGGAG---CGGAGACGGGAGGCC-------TGGCCTG-TCTCGGAACC ACTAGAG---AGAAGATAGAAGATT-------TGGTCTA-TCTCCAAGGT ACTAGAG---AGGAGATAGGAGACT-------TGATCTG-TCTCCAAACC -----AG---GGCAGATGGGAGGCCTGTCACATCTCACA-TCTCAGAATG GATGGGGCCAAGGAGCAGAGAGAGC-------CCGTTGGCTTTCTAAAGC * * ** ** * ** * 7700 -TGTGAGCTGCACCAGGTAGAAC-GCCAGGG-ACCCCAGAATCATGTGCG GTGTAAGCTGTACCAGGTAGAAT-GCCAGGG-ACCCCAGAACCACATCCA CTGTAAGCTGTGCCAGGTAGAAT-GCCAGGGGACTCTAGCATCACATCTA -TGTGAGCTGCAC-AGGTAGACC--CCAGGG-ACCCCAGAACCACATACA -TGGCCACCATCCTGGGCAGAACCACCAGGC-CCTCTGGGACCAT---CA ** * * ** *** ***** * * * * ** 7750 TCAGTCCAAGGGGTCCCCTCCAGG-AGTAGTGAAGACTCCAGAAATGTCC ACAGCCCAATGGGTCTCCTCCAGAAAGTAGTGAAGACTCCAGAAACATCC ACAGCTCAATGGGTCTCCTCCAGGAAGTAGTAAAGACTCCAGAAACAACC ACAGTCCACTGGGTCCCCTCTAGGAGGTAGCAAAGACTCCAGAAACCTCC GGAACCCAGGGGCCACCTTCCCA--------------TTCAGAGGTTTCC * ** ** * ** * **** ** 7800 GCATTTG (miR-105) human/mouse/rat/dog CTT----TCT--TCTCCCCCATCCTACGAGTAATTGCATTTGCTTTT--G CTT----TCTCTTCTCCCTGCTCCCATGAGTAACTGCATTTGCTTTT--G CTT----TCTCTTCTCCCTGCTCCCATGAGTAACTGCATTTGCTTTT--G CTT----TCTCTCCTCCCC-GTCCTACGAGTAACTGCATTTGCTTTT--G TCTCAATTCACATCCTGCCCCTTTCAGGCATTATTGCTTTCGGTGAGCAG * ** * * * * * * * *** ** * * * 7850 TAATTCTTAATGAGCAATATCTGCT--AGAGAGT-----TTAGCTGTAAC TAATCCTTAATGAGCATTATCTGCT--AAAAAAAAAAAATTAGCTGTAAC TAATTCTTAATGAGCAATATCTGCT--AGAAAGT-----TTAGCTGTAAC TAATTCTTAATGAGCAATATCTGCT--AGAG--T-----TTAGCCGTAAC TAGCTCCGAATTAGCAATACCTGTCTGAGAGAAT-----TGAGCTATCGA ** * *** **** ** *** * * * *** * 7900 AGTTCTTTTTG----ATCATCTTTTTTTAATAATTAGAAA---CACC--- AGTTCTTTTTGCAAAAGGATCATTCTTAAATAATTAAAAA---CACCCCC AGTTCTTTTTGCAAAAGAATCATTCTTAAATAATTAAAAG---CACCCCC AGTTCTTTTCG----ATCGTTTTTTTTAAGTAATTAAAAAAAACACC--- AATTCTTTTTG----------ATCCTTAA--AACTCGAAA---CACT--- * ******* * * ** * ** * ** *** 7950 AGCATTA (miR-155) human/mouse/rat/dog ------AAAAAA--------ATCCAGAAACTTGTTCTTCCAAAGCAGAGA CCCCAAAAAAAA--------GTCCAGAACCTTGTTCTTCCAAAGCAGAGA CCCCAAAAAAA---------GTCCAGAACCTT------CCAAAGCAGAGA ------AAAAAAAAAAAAAAACCCAGAAACTTGTTCTTCCAAAGCAGAGA -------------------------------CATTTTTCCAAAGCAGAG- *********** 8000 GCATTATAATCACCAGGGCCAAAAGCT---------------TCCCTCCC GCATTATAATCA---GGGCCAAAATCTGTCCCACACCTCTACCCCATCTC GCATTATAATCACCAGAGCCAAAATCTGTCCCACACCTCTACCACGTCCC GCATTATAATCACCAGGGCCAAAAGCT---------------TCCCTCCC ---------TCGCCAGAGCCAAAACCT---------------TCCATCCA ** * ******* ** * ** 8050 TGCTGTCATTGCTTCTTCTGAGGCCTGAATCCAAA-AGAAAAACAGCCAT CTC-ATGATTGCTGCTTCTAAGGCCAGAATACAGC-AAAGA--TATTTGT CTC-ATTATTGCTTCTTCTGAGGCCAGAACACAGC-AGAGA--TATTTGT TGC-ATCATTACT---TCTGAGGCCTGAACCAAAAGAGAAA--CGCTCAT GAC-GGTGTTGCTTTTTCCAGGGGCTCAGTCCACA-TATAAAGAGGAAAT * ** ** ** ** * * * * * 8100 AGGCCCTTTCAGTGGCCGGGCTACCCGTGA--GCCCTTCGGAGGA--CCA AGGCCCTTTGGGTGACTGGGCTACCCTTGG--AGCTCTTGGAAGA----T AGGCCCTTTGGGTGGCTGAGCTACCCTTGG--AGCTCTTGAAAGA----T AAGCCCTTTGGGTGGCCAGGCTACCCGTGG--GCCCCTCGGAGGA--CCT AAGTCTC------ACCCAGGTTGGCCAGGGCTGAGCCTTGAAAGGTCCCT * * * * * * ** * * * * * 8150 GGGCTGGGGCAGCCTCTGGGCCCACATCCGGGG--CCAGCTC-CGGCGTG GGGCTGGGGAAGCCTCTGAGACCCTATCCTAGGGCCTTGCTC-TAGGGAG GAGCTGGGGAAGCCTCTGAGACCCTATCCTAGGGTCTTGTTC-TAGAGAG GGGCTGGGGCAGCCTCTGGGCCCA-GCGTGGGG--CCCGCTC-CAGCCTG GGGCAGG---------TAGGCCTCGATTTGAGGAACCCACTCCCAGTGGG * ** ** * * * ** * ** * * 8200 TGTTCAGTGTTA-GCAGTGGG--TCATGATGCTCTTTCCCACCCAGCCTG TAATCAGTATTA-GTAGAGTG--TCACAACATTATTCCCCAGCCGGCATG TAATCAGTATTA-GTAGAGCA--TCACAACATTATTCCCCAGCCTGCATG CGCTCAGTATTA-GCGATGGG--TCACGTCGTCCTTTCCCACCCAGCCTG CACTCAGTATTAAGTCATGAGGTTTCCAGCACCATTCCTTTTTCAGCAAC ***** *** * * * ** * * ** 8250 GGATAGGGGCAGAGGAGGCGAGGAGGCCGTT-GCCGCTGATGTTT----G AGATGGGGGCAGAAGAAGCCAAAGGGTTGTC-TCCACTGCTACTTACTTG GGATGGGAGCAGAAGAGGCCAAAGGGTTGTCGTCAACGGCTACTT----G GGACGGGGGCAGAGGAGGCGAGGAGGCTGTT-GCTGCTGCTGTTT----- TGTTAGAGA---AGGGAGGGATGGGACTGCC-TCTGCTGCCGTTC----T * * * * * * * * * * * * 8300 GCCGTG----AACAGGTGGGTGTCTGCGTGCGTCCACGTGCGTGTTTTC- GCCACT----GACAGGTAGGTGACCATGTATGTCCATATGCATGTTTTA- GCCACT----GACAGGTAGGTGACCATGTATGTCCAA--GCATGCTTTA- GCCACT----AACAGGTGGGTGTCCACATGTGTCCACGTGCGTGCTTTC- GCCACTGGTGAGCGAGCGGGTGTCCTAGTGTGTCCTAGCGTGTGTGTTCG *** * * **** * * **** * ** ** 8350 TGACTGA--CATGAAA----TCGACGCCCGAGTTAGCCTCACCCGGTGAC TGGCTGA--TGTGAGA----TCAGCACCCAAGTTAGCTTCACCTGGTGAC TGGATTA--TGTGTGA----TCAGCACCCAAGTTAGCTTCATCTGGTGAC TGACGGAAGTGTGAAA----TCAGCGCCCAAGTTAGCCTCACCCAGTGAC TGGGTAA--ATGGACAACACTCGATACCAACACTTGCC--GGTTGGTCAC ** * * * ** ** * ** ** ** 8400 CTCTAGCCCTGCCCGGATGGAGCGGGGCCCACCC--------------GG CTCTAACCCTGCCTGGATGGAGCAGG--CCACCT--------------GG CTCTAACCCTGCCTGGATGGAGCAGG--CTACCT--------------GG CTCTCGCCC-GCCTGGACGGAGCAGGGCCCACCC--------------AG CACCACCACTGACGGCCCGAGAACGAGGACGCTCTTAGTGCTAAATACAG * * * * * * * * * * * 8450 TTCAGTGT------------TTCTGGGGAGC-TGGACAGTGGAGTGCAAA TTCAATGT------------TTCTGGGCAGC-TGGACAATGGAGTGCAAA TTCAAGGT------------TTCTGGGCAGC-TGGACAATGGAGTGCAAA TTGAGTGT------------TTCTGGGGAGC-TGGACGGTGGAGTGCGAA CTGAGTGTCCCAACTCTACATTCTCTGCAACATTGACAACCAAGTGCA-- * * ** **** * * * * *** ***** 8500 AGGCTTGCAGAACTTGAAGCCTGCTCCTTCCCTTGCTACCACGGCCTCC- AGGCTTACAGAACTTGAAGCCTTTTCCTTACTTTGCTAGCACGGCCTCCT AGGCTTGCAGAACTTGAAGCCTTTTCCTTACCTTGCTAGCACG------- AGGCTTGCAGAACTTGAAGCCTGCTCCTTCCCTTGCTACCAAGGCCTCCT ----------AACTCGAAGCCTGCTTCTTCCCTTGCCATCCAAGCCTCCC **** ******* * *** * **** * * 8550 TCCAGAG (miR-518c*) human/mouse/rat/dog TTTCCGTTTGATTTGTCACTGCTTCAATCAATAACAGC--CGCTCCAGAG TTTCCATTTGATTTGTCACTGCTTCAGTCAATAACAGC--CGCTCCAGAG TTTCCATTTGATTTGTCACTGCTTCAATCAATAACAGA--CGCTCCAGAG TTTCCGTTTGATTTGTCACTGCTTCAATCAATAACGGC--CGCTCCAGAG TTGT-----------GCGTTGCTCCAGTCAATACTAACAGCGCTCCAGAA ** * **** ** ****** ********* 8600 TC-------------------AGTAGTCAATGAATATATGACCAAATATC TC-------------------AGTAGTTGATGAATATATGACCAAATATC TC-------------------AGTAGTTGATGAATATATGACCAAATATC TC-------------------AGTAGTTGATGAATATATGACCAAATATC TCTGACTTCGCTTCAAGAATCACTAGTTGATGACCATATGACCAAATATT ** * **** **** ************** 8650 GACTGTT (miR-212,miR-132) human/mouse/rat/dog/opossum CTGTTAC (miR-194) human/mouse/rat/dog ACCAGGACTGTTA-CTCAATGTGTGCCGAGCCCTTGCCC-ATGC------ ACCAGGACTGTTA-CTCAACGTGTGCCGAGCCCTTTCCTTGTGC------ ACCAGGACTGTTA-CTCAATGTGTGCCGAGCCCTT-----GTGC------ ACCAGGACTGTTA-CTCAATGTGTGCCGAGCCCGTTCCTCGCGC------ CCAAGGACTGTTAATTAAATGTATGCTGAGTTCTTTCTCTGTACAGTTAG * ********** * ** ** *** *** * * * 8700 ----------TGGG-CTCCCGTGTATCTGGACACTGTAACGTGTGCTGTG ----------TGGGCTCCCTGTGTACCTGGACACTGTAATGTGTGCTGTG ----------TGGGCTCCCTGTGTACCTGGACACTGTAATGTGTGCTGTG ----------TGGG-CTCCCGTGTACCCGGACACTGTAACGTGTGCTGTG TTAGTTCTTCTAGGTTACCTATGTACCTGG-CGCCGTGGTGTGTGCTGTG * ** ** **** * ** * * ** ********** 8750 TTTGCTCCCCTTCCCCTTCCTTCTTTGCCCTTTACTTGTCTTTCTGGGGT TTTGCTCTCCTTCCTCTTCCTTCCTTGCCCTTTCCTTGTCTTTCTGGGGT TTTGCTCTCCTTCCTCTTCTTTCCTTGCCCTTTCCTTGTCTTTCTGGGGT TTTGCTCTCCT--CCCCTTCTCCCTCATCCTTCCATCGTTTTTCTGGGGT CTTTCTCTCTCTCTCCTTCCTGC------CTTTCGTTGTTGTCCTTAGGT ** *** * * * * * *** * ** * ** *** 8800 T---TTTCTGTTTGGG--TTTGGTTTGGTTTTT-ATTTCTCCTTT--TGT T---TTTCTGTT-GGG--TTTGGTTTGGTTTT--ATTTTTCCTTT--TGT T---TTTCTGTTTGGG--TTTGGTTTGGTTTT--ATTCTTCCTTT--TGT T---TTTCTGTTTGGG--TTTGGTTTGGTTTTTTATTTCTCCTTT--TGT TTTCTTTCTGGTTTGGCTTTTGATTTGGGATG--ATTTTTTTTTTAATTT * ****** * ** **** ***** * *** * *** * * 8850 GTGTTGA (miR-505) human/mouse/rat/dog GTTCCAAACATGAGGTTCTCTCTACTGGTCCTCTT-AACTGTGGTGTTGA GTTCCAAACATGAGGTTTTCTCTACTGGTCCTCTTTAACTGTGGTGTTGA GTTCCAAACATGAGGTTCTCTCTACTGGTCCTCTTTAACTGTGGTGTTGA GTTCCAAACATGAGGTTCTCTCTACTGGTCCTCTT-AACTGTGGTGTTGA GTATCCAGCCTGGGATT-TCTCTGCTAGTCTC--T-AACTGTG-TGTTAA ** * * * ** * ** ***** ** *** * ******* **** * 8900 GGCTTATATTTGTGTAATTTTTGGTGGGTGAAAGGAATTTTGCTAAGTAA GGCTTCTATTTGTGTAATTTTTGGTGGGTGAAAGGAACTTTGCTAAGTAA GGCTTCTATTTGTGTAATTTTTGGTGGGTGAAAGGAACTTTGCTAAGTAA GGCTTATATTTGTGTAATTTTTGGTGGGTGAAAGGAAATTTGCTAAGTAA AAGTTCCTATTGTGTATTGCTCGATTG-TAAAAGGAGCGTTTCTAAGTAG ** ******* * * * * * * ****** ** ******* 8950 ATCTCTTCTGTGTTTGAACTGAAGTCTGTATT-GTAACTATGTTTAAAGT ATCTCTTCTGTGTTTGAAATGAAGTCTGTATT-GTAACTATGTTTAAAGT ATCTCTTCTGTGTTTGAAATGAAGTCTGTATT-GTAACTATGTTTAAAGT ATCTCTTCTGTGTTTGAACTGAAGTCTGTATT-GTAACCATGTTTAAAGT ATCTCTTCTGTGTTTGAGCTAAAGTCTGTATTTGTAACCATGTT-AAAGT ***************** * *********** ***** ***** ***** 9000 TCCAGAG (miR-518c*) human/mouse/rat/dog/opossum AATTGTTCCAGAGACAAATATTTCTAGACACTT----------------- AATTGTTCCAGAGACAAATGCTTCTAGGTACAT----------------- AATTGTTCCAGAGACAAATGCTTCTAGGTACAT----------------- AATTGTTCCAGAGACAAATGCTTCTAGACACCT----------------- AATTGTTCCAGAGACAAATACTTCTAGACATTTGGGGGAGGGCGGGGAGG ******************* ****** * * 9050 ----------------------TTTCTTTACAAACAAAAGCATTCGGAGG ----------------------TTTCATTACAAACAA-AGCATTTGAAGG ----------------------TTTTATTACAAACGA-AGCATTGGAAGG ----------------------TTTCTTTACAAACAAACGAATTTGGAGG GGAGGGCTAGATGAATCAATTCTTTTTTTAAAAGTGGAGGCTAAAAGTGA *** *** ** * * 9100 GAGGGGG----------------ATGGTGACTGAGATGAGAGGGG----- GAGGGAA----------------GTGGTGAATAAGACAAGAGGGG----- GAGGGG-----------------GTGGTGAATAAGACAAGAGGGG----- GAGGGG-----------------ATGGTGACCAAGATGAGAGGGGCTGTC AAAAGAGCTTCTTTTTCCCTCTAGGGAGGCCTGAGGCTTGCTGAG----- * * * * ** * * * 9150 ------------------AGAGCTGAACAGATGACCCCTGCCCAGATCA- ------------------CAATCTGAAT---TGATCCCTGCCCAGATCA- ------------------CAATCTGAAGAGATGACCCCTGCCCAGATCA- CTTTTTCCCCAGGAGGGGAGATTCGAAGAGATGACCCCTGCCCAGACCA- ------------------GGGGCC--ATAACTCCCCTCAGCCCTGCCCAT * * * * **** * ** 9200 -GCCAGAAGCCACCCAAAGCAGTGGAGCCCAGG--------------AGT -GCCAGAAGCTACC---AAAAGTTAAGCACTGG--------------TTT -GCCAGAAGCTATC---ATAAGTTAAGCACTGG--------------ATT -ACCAGATGCCACCCAAAGAAGTTAAGCCTA-A----------------- GGCCAAAAACCACATG-AGAAGCAAAGCCTGCTGGGGCCTCTCTGCAAAT *** * * * * ** *** 9250 CCCACTCCAAGCCAGCAAGC------CGAATAGCTGATGTGTTGCCACTT TCCATTCCAAGTCAAGAGAC------TGAA--GCTGATGTTTTGCCATTT TCCATTCCAAGTCAAGAGAC------TGAA--GCTGATGTGTTGCCATTT ----------GCCAACGGAC------CAAATAGCTGATGTGTTGCCATTT CCCTTTCAAAGCCAACACACATGCATCCAGGAGCTGATCTGTCTCTGTTC * ** * * ****** * * * * 9300 TCCAAGTCACTGC-AAAACCAGGT-TTT----------GTTCCGCCCAGT TCAAAGTCAAAGC-AAAACCAGCT--------------TTTCCACCCAAT TCAAAGTCAAAGC-AAAACCAGCTAGCT----------TTTCAACCCAGT TCAAAGTCAGAGC-AAAACCAGGT-TTG----------GTTCCACCCAGT TCTTGATCTTGGCTGAAAGCAGTT-TTTCTTGAAGGAGGTTTCTCCCACC ** ** ** *** *** * ** **** 9350 GGATTCTT--GTTTTGCTTCCCCTCCCCCCGAGATTATTACCACCATCCC GGATTCTT---------TGCTTCTCCTTCCCAGATTATTACTACTGCTGT GGATTCTT---------TGCTTCCCCTTCCCAGATTATTACTACTATTGT GGATTCTGTTGCCTTTCCCACCCCCCCCCCGAGATTATTAGCATCATCCT TG---------------------TGGTCCCCAGTGAATTACTTTGTCAGT * ** ** **** 9400 GTGCTTTTAAGGAAAGGCAAGATTGAT---GTTTCCTTGAGGGGAGCCAG ------------------------AAT---AATCT----AGGAGTGCCAG ------------------------AAT---AATCT----AGGAGTGCCAG -TCTTTTTAAAGCCAGACCAGGTTGAT---GTTCCTTTGAAGGGAGACAG -TTCCTGAAAAATGCCACAGGTTTAGTTTAGTTTCACTGGGGAAAGAGAG * * * * ** 9450 GAGGG---GATG-----------TGTGTGTGCAGAGCTGAA-------GA GAGGGAAAGGAG-----------TATTAACACAGAGCTGTGC------TC GAGAGAAAGGGA-----------TATGAGAGCAGAGCTGAGC------TC GAGGG-------------------GTGCAAGCAGAGCCGACCTTGTGTCC GAGAC---AGTGGTTCTTTTTCTTTTGTAGGGAGAATTGGG-------AA *** * *** * 9500 GCTGGGGAGAATGG----------------GGCTGGGCCCACC------- ACTGAGTATGGAAA----------------GGCTTGGTCTGAG------- ACTGAGTATGGAAA----------------GTCTTGGCCTGAG------- GCGGGAGGAAGATA----------------GGGCAGGCCTGAGGAG---- GAGAGGGAGGAAAGCTAAGCAGACATTGGAGCCAGGATCTGTGCAGGTTA * * * 9550 ----------CAAGCAGGAGG-----------CTGGGACGCTCTGCTGTG ----------TTTTCAGGAGG----------------ATGACCCACTGTG ----------TTTTCAGGAGG----------------ATGCTCCACTGTG ---CAGAGCTCAGACGAAGGGTGGTCATCTCCCTGGAGACCTCTGCTGTG TTTAAAGAGTTTATAAAGAGA----------------GAACTCTATTTTT * * * * 9600 GGCAC---AGGTCAGGCTAATGTTGGCAGATGCA---------------- GACAT---GGG-----GAGAAGACAGAAGATAAA-TTAGCCGCTCCCTGC GACAC---AGG-----GAGACGACAGAAGATGAA-TTAGCCTCTCCCTGT GCCAC---AGGTCAG-TGTATGTTGACAGGGCAGACTGGCCCCTCTCCAC ACTATGATAGGTCACTTAGGTTTTCAAAAAGGAAGTAAATCATTGTCAGC * ** * 9650 ----------------GCTCT----TCCTGGAC-----------AGGCCA CTA--------AGATACCTCT----TAATAGAT-----------AAGTCA CTG--------AAATACCTCT----TAATAGAT-----------AAGCCA CTG--------ACGCAGCGCT----TCCTGGAC-----------AGGCCA CCAGACTGGGAATCCAACTCTACCCTCCTGAACGTTAATTCCCCAAATTA * ** * * * * * 9700 -GGTGGTGGGCATTCTC-TCTCCAAGGTGTGCCCCGTGGGCATTACTGTT AGGCCATGGACATTATTGTCTACAAGGCATGTTTCAAAGACATGACCAGT AGGCCATGAACATTATTGTCTCCAAGGCATA-------------ACCAGT -GGTGGTGGGCATT------------------------------ACCGTT -GCCGAAGG---------TTTACATGCCACCCTCATTGGGATTCGCCACT * * * * 9750 TAAGACACTTCCGTCACATCCCACCC-----CA-TCCTCCAGGGCT--CA CAGGACACTTCTGTCATACTCCATGT-----TG-CCCCCTAGTACA--CA CAGGACACTTGTGTCAAACACTATGA-----TG-TCCCCTAGTGCA--TA CAGCACACGCCCATCACATCCCACCCAGTACCA-TCCCAGAGTACATCCA TAAAACTTC---------CCCCACCT-----AACTCCCATAATGCA--CA * ** * * ** * * * 9800 ACACTG---TGACATCTCTATTCCCCACCCTCCCCTTCCC--AGGGCAAT GTACTAATCTGATATCTCTGTTCC-CGCCATGCCT--------GGGGGAT GTAATAATCTGATATCTCTGCTCC-CACCATGCCT--------GGGGGAT ACATtgacatgacctctagattcttcaccatcct---------ggGTGAT TAATTAACAAGAAGGCTTTTT-----GCCGCCTTTTTTTCTAATGGCAAC * * ** ** ** ** * 9850 AAAATGACCATGGAGGGGGCTTGCACTCTCTTGGCTGTCACCCGATCGCC AAAATGA---TAGCAGAGACTCCTTTCCT--TCAATGTGATCTAATTCCC AAAATGA---TAGCAGAGACTTCTCTCCT--TTGATGCTATCTGATTCCC AGGACGACGGTGGAGGAGGTGCACTCTCT--TTGCCGTCCTCTGACCCCC AAATCAATTTTGGAGGGTCCCCCTTTCTT--TGATTTCT-TTTGGCCCCT * * * * * * * * 9900 AGCAAAACTTAGATGTGAGAAAAC-CCCTTCCCATTCCATGGCGAAAACA AACAAAATCTGGGCCTGAGATACC-ACCTG---TTTCTATGGC--AAACA AACAAAATCTTGACATGAGATACC-ACCTTCTCTTCCTATGGC--AAACA AGGAAAATCTGAGCGTGAGAAACCCCCCATCCCTTCCCTTAGCAAAACCA AGT------------------CAC-ATTTGCCCCTTCCATAGTGAAAG-- * * * * * * ** 9950 TCT-CCTTAGAAAA--GCCATT--ACCCTCATTAGGCA--------TGGT TCC----TCAGTAA--AGTGTT--ATTCTCATTGCAGA--------TTGT TCT----TCAGTAA--AGTGTT--ATCCTCATTACAGA--------TTGT GATACTTCTGAGCAAAGCCGTT--ACCCCCACCAGACA--------TTGT -------AAAAAAA--GCAGATCCACCCCCTCTAGGCAAAAGAGGTGGGC * * * * * * * 10000 TTTGGGCTCCCAAA---------ACACCTGACAGCCCCT----------C TCCAGCCTAATGTAAGAGGAAC-AGAGCAGTGTTCCCTTGG-------AG TCCAGGCTCTTGTA-GAGGAAC-AGATCTGTGCTCCCTTGT-------AC TTTGGGCTCACAGAACAGGGAC-AGATGTGTGCTCCCTTAGCACCCAGCC TGGAGGCACTGGGCACAGGATTGACACCTG-------------------C * * * * * * 10050 CCTCCTCTGAGAGGCG--GAGAGTGCTGACTGTAGTGACCA-TTGCATGC CCTCATGTG---------GACAGTTCTACCTGTAGTGACCAGTTGGCTAT CCTCATGTGAG-------GACAGTGCTACCTGTAGTGACCAGTTGGCTAT CCCCCCCCAAAAGGCGAAGACAATGCTGAGTGTCATGACTATTTGCACAT CCCCATCT----------GCCCCTACT--TTCCAGAAACCA--------- ** * * * ** * ** * 10100 CGGGTGCAGCATCTGGAAG-AGCTAGGCAGGGTGTCTGCCCCCTCCTGAG AGTAGTTATTAGCTGGAAC-AACCAGACAGGGTACATGCCCCCTCCAAAA GGTAGTTATTAGCTGGAAG-ATCCAGACAGGGTACAT-CCCCCTCCTAAA GGG-TTTAGTATCAGGAAGGAACCAGGCAGGGTAGCTGTCCCCTCCTGAG ------CAGAACCTTCAAG-AGTT--------TAAGTGCCCC-------- * * * ** * * * *** 10150 TTGAAGTCATGCTCCCCTGTGCCAGCCCAGAGGCC----------GAGAG TCCATGTTGTACTCCCCTCTGCCAG-CCAGGGGGG----------GTGAG TCCATGTTGTACTTCTGTCTGCCAG-CCTGGGGGGTTGGGGGGAAGCGAG TCA----------------------------------------------- TTGCAGTTCAGCTCCAAAGCCTCA-------------------------- * 10200 CTAT---GGACAGCATTGCCAGTAACAC--AGGCCACCCTGTGC------ ATCTGTAGAATAGTGCAGCCAGTGACA----AGCCACCTTGTGT...... ATCTATAGGATAATGCGGCCAGTGACA----AGCCACCCTGTAT...... -------------------CAGTGACCC--CGGCCACCCTGGAC...... --CTATGGGATGGGAGAGATGGCAGCCCCTAGGCCATGCTGAC------- * * **** ** 10250 --AGAAGGGAGCTGGCTCCAGCCTGGAAACCTGTCTGAGGTTGGGAGAGG -----------------CCAGCTCAAAAACTCATCTAAGGTTGGGAGCAG -----------------CCAGCTCAAAAACCCATCTAAGGTTGGGA---- ..-----------------------------------------GGAGAGA --AGAACGCA------C------------CCCCACTGGAGAGGGAA---- * * 10300 TGCACTTGGGGCACAGGGAGAGG-CCGGGACACACTTAGCTGG-----AG -GCAGACAAGGCAGAGAGAAAGATCCAGGACAGACCTAGCTGGGCTGGAG --CAGACAAGGCAGAGAGAAAGATTCAGGACAGATATAGCTGG-----AG GGCGTGTGTGGGACAGGGAGCAGCCCAGGACAGACTTGGCTAG-----AG ------TGGGGAAATGGGGTA---TTGAGGGGAACCAACCTCT------- ** * * * * * ** 10350 ATGTCTCTAAAAGCCCTGTATCGTATTCACCTTCAGTTTTTGTGTTTTGG GGGTCTTGAAAAGCCCTCTGTCGTATTCACCTTCAGTTTTTGTGCTTTGG GGGTCTTGAAAAGCCCTCTGTGGTATTCACCTTCAGTTTTTGTGCTTTGG ATGTCTCCAAA-GCCCTCCATCACATTCACCTTCAGTTTTTGTGTTTTGG ---TCCTCAA--GCCCTCGATTGCATTCACCTTGGGTTTTTGTGTTTGGG ** ** ***** * ********* ********* ** ** 10400 GACAATTACTTTAGAAAATAAGTAGGTCGTTTTAAAAACAAAAATTATTG GACAATTACTTTAGAAAATAAGTAGGTCGTTTTAAAAACAAAA--TATTG GACAATTACTTTAAAAAATAAGTAGGTCGTTTTAAATACAAAA--TATTG GACAATTACTTTAGAAAATAAGTAGGTCGTTTTAAAAACAAAAAATATTG GACAATTACTTTAGAAAATAAG---------------------------G ************* ******** * 10450 TTTGTAG (miR-520d*) human/mouse/rat/dog/opossum ATTGCTTTTTTGTAGTGTTCAGAA-AAAAGGTTCTTTGTGTATAGCCAAA ATTGCTTTTTTGTAGTGTTCAAAACAAAAGGTTCTTTGTGTATAGCCAAA ATTGCTTTTTTGTAGTGTTCAAAACAAAAGGTTCTTTGTGTATAGCCAAA ATTGCTTTTTTGTAGTGTTCAAAA-AAAAGGTTCTTTGTGTATAGCCAAA ATTGCTCTTTTGTAGTGTTCAA---AAAAGGTTCTTTGTGTATAGCCAAA ****** ************** ************************* 10500 ACTGAAA (miR-30a-3p,miR-30e-3p) human/mouse/rat/dog/opossum AAGCACT (miR-520f) human/mouse/rat/dog/opossum TGACTGAAAGCACTGATATATTTAAAAACAAAAGGCAATTTATTAAGGAA TGACTGAAAGCACTGATATATTTAAAAACAAAAGGCAATTTATTAAGGAA TGACTGAAAGCACTGATATATTTAAAAACAAAAGGCAATTTATTAAGGAA TGACTGAAAGCACTGATATATTTAAAAACAAAAGGCAATTTATTAAGGAA TGACTGAAAGCACTGATATATTTAAAAA---AAAGCAATTTATTAAGGAA **************************** ** **************** 10550 ACCATTT (miR-522) human/mouse/rat/dog/opossum CATTTCA (miR-203) human/mouse/rat/dog/opossum GTAAACC (miR-299-5p) human/mouse/rat/dog TGAATGT (miR-181a,miR-181b,miR-181c,miR-181d) human/mouse/rat/dog/opossum ATTTGTACCATTTCAGTAAACCTGTCTGAATGTACCTGTATACGTTTCAA ATTTGTACCATTTCAGTAAACCTGTCTGAATGTACCTGTATACGTTTCAA ATTTGTACCATTTCAGTAAACCTGTCTGAATGTACCTGTATACGTTTCAA ATTTGTACCATTTCAGTAAACCTGTCTGAATGTACCTGTATACGTTTCAA ATTTGTACCATTTCAGTAAATCTGTCTGAATGTACCTATATACGTTAAAA ******************** **************** ******** ** 10600 TATTATA (miR-374) human/mouse/rat/dog/opossum AAACACCCCCCCCCCACTGAATCCCTGTAACCTATTTATTATATAAAGAG AAACACACCCC----ACTGAACCCCTGTAACCTATTTATTATATAAAGAG AAACACACCCC----ACTGAACCCCTGTAACCTATTTATTATATAAAGAG AAACACCCCCCC---ACTGAATCCCTGTAACCTATTTATTATATAAAGAG GAAGTCCCCTCCCC-CTCAAATCCCTGTAACCTATTTATTATATAAAAAG ** * ** * ** ************************* ** 10650 TGCCTTA (miR-124a) human/mouse/rat/dog/opossum TTTGCCTTATAAATTTACATAAAAATGTCCGTTTGTGTCTTTTGTTGTAA TTTGCCTTATAAATTTACATAAAAATGTCCGTTTGTGTCTTTTGTTGTAA TTTGCCTTATAAATTTACATAAAAATGTCCGTTTGTGTCTTTTGTTGTAA TTTGCCTTATAAATTTACATAAAAATGTCCGTTTGTGTCTTTTGTTGTAA TTTGCCTTATAACTTTACATACAATGTCCTTTTTGTGTCTTTTGTTGTAA ************ ******** ** * ******************* 10700 AAATCAAGTGATTTTTTCATAAGGTTCTTTTACTATTGGAAAAGATGGGC AA-TCAAGTGGTTTTT-CATAAGGTTCTTTTACTATTTGAAAAGATGGGC AA-TCAAGTGGTTTTT-CATAAGGTTCTTTTACTATTTGAAAAGATGGGC AA-TCAAGTGATTTTTTCATAAGGTTCTTTTACTATTTGAAAAGATGGGC G--CCTAGTGGTTCCCCCTCGAG--TCTTTTCTTCTTGGAAAAGATGGGC * **** ** * ** ****** * ** ************ 10750 AGCACGCAGTTTTATTTTATTTTTGTAAGTTTT--TTAATACATGTGAAA AGCACGCGGTTTCATTTTATTTTTGTAAGTTTT--TTAATACATGTGAAA AGCACGCAGTTTCATTTTATTTTTGTAAGTTTT--TTAATACATGTGAAA AGCACGCAGTTTTATTTTATTTTTGTAAGTTTT--TTAATACGTGTGAAA AGCACGCTATTGGACTTTCTTTCTGTGAGTTTTCCTTTCTACCTGTAAAA ******* ** * *** *** *** ****** ** *** *** *** 10800 TTTGCAC (miR-19a,miR-19b) human/mouse/rat/dog GCACCTT (miR-18a,miR-18b) human/mouse/rat/dog GCAAAGAATACTCAGCATGC----CTTTCTAAGTGACGCGTTTGCACCTT GCAAAGAATACTCAGCATGC----CTTTCTAAGTGATGCGTTTGCACCTT GCAAAGAATACTCAGCATGC----CTTTCTAAGTGATGCGTTTGCACCTT GCAAAGAATACTCAGCATGC----CTTTCTAAGTGACGCGTTTGCACCTT GC--AGAATACTCAGCATGCATTTCTCTCTAAGTGACTAGTTTGCATCTT ** **************** ** ********* ******* *** 10850 GTACTGT (miR-101) human/mouse/rat/dog/opossum TTGTTGGGAAGTACTGTATCCTGTGCTGTTAGCATTC-TCGATAAATCTC TTGTTGGGAAGTACTGTATCCTGTGCTGTTAGCATTC-TCGATAAATCTC TTGTTGGGAAGTACTGTATCCTGTGCTGTTAGCATTC-TCGATAAATCTC TTGTTGGGAAGTACTGTATCCTGTGCTGTTAGCATTC-TCGATAAATCTC TTGTTGGTAAGTACTGTATCCTGTGCTGTTAGAATTTATCTATAAATCTA ******* ************************ *** ** ******** 10900 TCTGTGAAAGTGACTCAAGGTCTGGGCTTTCATTATAAGACAGAAGTCCC TCTGTGAAAGTGACTCAAGGTCTGGGCTTTCATTATAAGTCACCAGTCCC TCTGTGAAAGTGACTCAAGGTCTGGGCTTTCATTATAAGTCACCAGTCCC TCTGTGAAAGTGACTCAAGGTCTGGGCTTTCATTATCA------------ TGTA-AAAAGTAATTCAAGGTCTGGGCTTTCATTGCAAGGCAGAAACCCC * * ***** * ******************** * 10950 CCTCCAGCTCACATGACAGCATG-GTGCTGCGTTTCCTCATTGGATCTGG C-TCCAGCTCACCTGACAGCATG-ATAT-----------GTTTGATTCAG C-TCCAGCTCACGTGACAGCATG-GTAT-----------GGTCAATTCAG --GACAGCTCACAGGACAGCACG-GTGCTGTGTTTCCTGATTCCGTCTGG CAATCAA-----ATAACACCATGCGAGAGGCGGTTTTT---CCGACTTGA ** *** ** * 11000 CTGTC CTATC CTATC CTGTC CCTTC * ** 11050