# Aligned 3'UTR sequences of COREST in the order of human, mouse, rat, dog and opossum. # Predicted miRNA targeting sites are annotated on top of the alignment with miRNA seeds indicated. # Only miRNAs with seeds perfectly conserved in human,mouse,rat and dog are shown. # Only miRNAs with seeds prefectly conserved in all mammals including opossum are reported in the paper. # >corest.utr3 hg17.chr14:102262597-102266750,+ mm7.chr12:108628334-108632379,+ rn3.chr6:135864557-135868581,+ canFam2.chr8:73673286-73677499,+ monDom2.scaffold_6:86425492-0,+ GAAA--CTGGTGGCTTTGAACACTTGGTGTGGACTACTGTGTTATCCGGG AAACTGTTGGTAGCTTTGAACACTTGGTATGGAC-GACACGTTATCCAGG AAACTATGGGTAGCTTTGAACACTTGGTATGGAC-GACATGTTATCCAGA GAAACTCTGGTAGCTTTGAGCACTTGGTATGGACGACTGTGTTCTCCAGG AAGACTTGAGTAGCTTAGAATAATTTGCGTTAACTACTG--TTATTCAAG * ** **** ** * ** * * ** ** * * 50 ATATCAGGTATTATGAGACATCACCTAGCCATCTGCATCACATCTCTCTG -TATCAGGTATTACAAGACATCACCTAGCCATCTGCATCACATCTCTGTG -TATCAGGTATCCCAAGACATCACCTAGCCATCTGCATCACATCTCTGTG ATATCAGGTATTACAGGACATCACCTAGCCATCTGCATCACATCTCTGTG ATATCAGGTATTACCGAACCTCAGACAGCCATCTGCATCATACCTTTGTG ********** ** *** ************** * ** * ** 100 GACAAGCAGCTATTACCAAAAAAGGCATATACTTCCAGTCCTGTGCTCCA GACAAGCAGCTATTACCAAAAAAGGCATACACTTCCAGTCCCGTGCTACA GACAAGCAGCTATTACCAAAAAAGGCATACACTTCCGGTCCT-CGCTACA GACAAGCAGCTATTACC-AAAAAGGCATACACTT-CAGTCCTGTGCTCCA GACAAGCAGCTATTACCAAAAAAGGCAAACACTTCCAGTCCTGTGCTGCA ***************** ********* * **** * **** *** ** 150 TGCCTTA (miR-124a) human/mouse/rat/dog/opossum TCTGCCTTAATTCTTTGCTCGTTCCTCCATGTTGGCGCCACTTCCCAGAG TCTGCCTTAATTCTTTGCTCGTTCCTCCATGTTGGCACGACTTCCCAGAG TCTGCCTTAATCCTTTGCTCCTTCCTCCATGCTGGCACGACTTCCCAGAG TCTGCCTTAATTCTGTGCTCGTTCCTCCATGTTGGCGCCACTTCCCCGAG ACTGCCTTAATTCTTTGCTCATTCCTCTGCATTGCCTCCACTTCCCAATT ********** ** ***** ****** ** * * ******* 200 AGCTCCACT--GCATCTCA--CACTCTGCCCACGTGCTGGGGAAGTCTCA AGCTCCGTT--GCATCTC----ATTCTGCCTAAGGGCTGGGGGA--CCCA AGCTCCGTT--GCATCTC----ACTCTGCCTAAGGGCTGGGGGA--CCCA AGCCCCATTGCATCTCTCA--CACTCTGCCCAAGTGCTGGGGAG-TCTCG TGCTTTTT---GTTTCATCAGTAC-CTGCCTGAATGCTGGGGAGAATCAC ** ** * ***** ******* 250 CGGCCTGCACATCTCTTGTGAC----TCTGGGAACCGCC-TCTCCCGCCG CGGCCTGCACACCTCCCTCGAG----TCTGGGACCTACC--CTCCAGTTG CGGCCTGCACACCTCCCTCGAG----TCTGGGACCTACC--CTCCAGTTG TGGCCTGCACGCCTCC--TGAC----TCTGGGGAC--CTGTCCCCAGTCG CGTACCCCACATCGCTTGTGGGCTTATTTTTGAACTGTCTCCATAAGAAG * * *** * * * * * * * * * * 300 GGCAGCT (miR-22) human/mouse/rat/dog GAG--CCCCCGAGCCCCACCAATGGCAG-CTCTTCCCAGTCAGCAGCTTC GCTCCCCCCCGAGCCCCAACAATGGCAG-C-TCTCCCAATCAACAGCTTC GCT-CCCCCTGAGCCCCAACAATGGCAG-C-TCTCCCAGGCAACAGCTTC AAG--CTCCTGAGCCCCACCAATGGCAG-CTCTGCCCAGTCAGCAGCTTC GAG--CTACTGAATTATTCTCCCTGCAGTCTCGTGGTAATCGGCAGGGAG * * ** **** * * * *** 350 AGAGCAGGC------AGTCTCCTTGGAAGGCCCGACTCTGTTCCTGCATG AGAACAGGT------AGT---CTTGAAAGGCCCAGCTCTGTTCCTGCATG AGAACAGGT------AGT---CTTGAAAGGCCCAGCTCTGTTCCTGCATG -AAACAGGT------AGTCAACTTGGAAGGCACGACTCTGTTCCTGCATG TGGAAGGGGGAGAAGAGTCAGCTCAGAAGGTCTAA--------CTGTATT ** *** ** **** *** ** 400 GCCTGCAGTTTCTACTTTGTGCATAGAGTCATTTTCAGAGTCACCGCGAC GCCTGCAGTTTCTACTTTGTGCATAGTGTAATTCTCAGA-------AGGC GCCTGCAGTTTCTACTTTGTGCATAGTGTAATTCTCAGA-------AGGC GCCTGCAACTTCTACTTTGTGCATAATGTAATTTTCAGAGTGACTGTGAC GCCTGTAATCTTTGCTTTGTGCATAGTGTAATTATAATAGT------GAC ***** * * * *********** ** *** * * * * * 450 CCTGTTGGCCTTCTAGAAAGTTTCTTTTGTTCTTTTCTGAG----ACAAC CTAGTAGACCTTCTAGAAAAAGTCTCCCCTTCTCTCCTGGG----GCAGC CCAGTAGGCCTTCTAGAAAGATTCTCCCCTTCTTTTCTGGG----GCAGC CCTGTTGGCCTTTTAGAAAGTTTCTCTTGTTCTTTCCTGAG----GCATC ACTCTTAGCTTTCCAGGAAGAGCCTACTATTCATTTTTGAGTTGACTGAC * * ** ** ** ** *** * ** * * 500 CACCTAAGTGATAATACGCTTTTTTGGAAACTAA-TA--TATATTGCCAG CACCTAAGTAAAATCATGCTTCTTTGGAAATCACAAG--CCCTTCAGCAG CACCTAAATACAATCATGCTTCTTTGGAAATCAC-AG--CCCATCAGCAG CACCTAAGTGATATCATGCTTCTTTGGAAATCCC-AG--TATATTGGCAG CACCTT-GAGACATCATGCTTCCTCTGAAAACAT-AGTCTGCATTTGTAA ***** * * **** * **** * * 550 ACTGCATC--ATAACCTTTATCATGCCAAGCATCCTGATGCAACTCACAT ACCACATC--GTCACCTTTATCATA-CAAGCTTCCTGATACAACTCCTGT ACCACATCGTGTAACCTCCATCAC--CAAGCTT-CTCATGCAACTCC-GG ACTGCATT--ATAACCTCCATTGTGCCAAACATCCCGAGACAGCTCACGT ACTGCATC--GTGACTTTT-TAGTGCTGAGCGTTCCAGTGCCATTCATGG ** *** * ** * * * * * * * ** 600 TTCCCTAAACATGGGGTACAGT------------TATGA--TTTATAAAT TTCCCTAAGAGAGGACAGTTATGGCTGTAGATCAGGTGGCTTCTCTCCCC TCCCTAAAGAGAGGGCAGTTATGGCTATGGATCAGGTGGCTTCTCTCCCC TTCCCCAGACGCTGGGTGTAAT------------TATGG--TTTGTAAAT TCTCCTCAACTTAGGTCCTAAT------------GATGG--TTTATAATT * * * * ** * * * 650 -TGAGT-------TGGCTTAA-------ATCTC---CCTCTTCTCCCTTC TTTCTC-------TCTCCCCT-------AACTCTTTCCCTTTTCTCCTTT -TTCTC-------TCTCCCCT-------AACTCTTTCCCTCTTCTCCTTT -TTAGC-------TGGCTTAA-------ATCTC---ACCCTTCTCCTT-C -ATTGGACCATAATGGCTTAATGACGGTGTCTT---TTTTTAAGCCAATC * * ** * 700 CCAAGTG----------TTACAAAGATCATTTACTGC-----AACTGTCG CCAAGTG----------GTA-AAAGCTCATTTGCAGC-----AACTGTCC CCAAGTG----------GTA-AAAGCTCACTTGCAGC-----AACTGTCC CCAAGCG----------GTAGAAAGCTCATTCACAGC-----AACTGTCC CCTAATG..........GTGGAAAACTCACTAGTAGTGTACAGACCAGCC ** * * * *** *** * * ** * 750 TTGGACACTGTAGCTTAAAGGGAACGTGGACCTCAATGCTTTCTGCCTTC TTGGGCACTGTAGCCTCATGGGAACGTGGACCTCAGTGCTTTCTGCCTTC TTGGACATTGTAGCTTAACGGGAGCGTGGACCTCAGCGCTTTCTGCCTTC TTGGACACTA--GCTTAA-AGGAACATGGACCTCAACACTTTCTGCCTTC TGGGTTACTGTAGCTTCAAGGTTTGGTTGAGTAAAGTGCCACC--ACATC * ** * * ** * * * * ** * * * * ** 800 AACTTTTCAGCATTGTGACCCCAGGGTGG--TTGCCACCCCATCTTTTCC AGCCT-TCAGCATTGTAATCCCAGGATGA--GGGTGCACCCATCTCTTCT AGCCT-TCAGCATTGGAGTCCCAGGAAGT--GGGTGCGCCCATCTCTTCT AGCTT-TCAGCATTGTAATCCCAGGACGGGTGTGCCACCCTGTCTTTTCC ATCAT-TTTGCATAGTAACCCTGGTCAGG---------CACACCTTCCCC * * * * **** * ** * * * ** * 850 TGACCCCCC----CCACC--CC---C--C--CACCTCCAAGAGGTTCGGC TGATCCCCAGCTGCCACCATCATC-C--C--CAGCTCCGAGAGATTTGGT TGATCCCCAGCCACCACCATCACCAC--C--CAGCTCTGAGAGATTTGGT GGATACCC-----CCACCCCAC---CATC--CAACTCCAAGAGATGCGGT TACACTCTACTCCCTACCTTTC---T--CAGTATCCCCTACAGATTGAAT * * *** * * * * * ** * 900 TGGTGCT (miR-29a,miR-29b,miR-29c) human/mouse/rat/dog/opossum GTGCCTT (miR-506) human/mouse/rat/dog/opossum CCACATCACTGTACCTGGTGCTTGTAAATTTGGAATTGGTGCCTTCTCCT TCCTATCATTGTACCTGGTGCTTGTACATTTGGAATTGGTGCCTTCTCCT TCATATCACTGTACCTGGTGCTTGTACATTTGGAATTGGTGCCTTCTCCT CCATACCACTGTACCTGGTGCTTGTGCATT-GGAATTGGTGCCTTCTCCT CCAAACAACTTTATCTGGTGCTCATCCATTTGGAATTGGTGCCTTTTACA * * * * ** ******** * *** ************** * * 950 TTTGGCAACCATGGTTATCAATCCTTTTTCTGTTTTAGTGTCTTATTTCT TCTGGCAACCATGT-TATCAATCCCTTTTCTGTTTAAGTGTCTTACT--- TCTGGCAACCATCC-TATCAGTCCTTTTTCTGTTCAAGTGTCTTATT--- TTTGGCAACCATGT-TATCAACCCTTTTTCTGTTTTAGTGTCTTATTTCT TTTGGCATCCATAT-CACCA----TTATGCT---TCAAAGTCATCTTCTT * ***** **** * ** * * ** * *** * * 1000 TCTTTCAAGTTATTTGCTAGCCAAAGATGAC----ATCAC-TGAGAT-TA ----TAAAGTTTATTGCTTGCCAAAGATGCC----ATCAT-TGAGGTGTA ----CAAAGTTTATTGCTTGCCAAAGATGAC----ATCAT-TGAGGTGTA TCTTTAAAGTTTATTGCTTGCCAAAGATAAC----ATCAC-TGAGAT-TA TCCTTAAAGCTTGCTGCTTGCCAAAGATGATTGTAGTCATGTGAGGGGTG *** * **** ********* *** **** * 1050 GGAGACAGGGGAGAGCTTGCTGCAGATTCTGA---CAGTGCAGATTTTAA GCAGAT-GGGGAGGGTGT-CTGCAGGTTT------GAGTGCAGACTTTAA GCAGAT-GGGGA--GTGT-CTGCAGACTT------GAGTGCAGACTTT-A GGAGACAGGGGAGAAATTGCTGCAGATTCTGACA-GAGTGCAGATTTTAA GCAAGCATGAGTGTGCTTGCCATAGATCCTGACAGGAGCACAGGTTTAAA * * * * * * ** ** *** ** * 1100 ATGT---------------CAGGATATTAGAATAGCTGGCG---CTGGTT ATGTCAGGTCAGCTCAGGAAAGGAGAAGAGAGAAGCTAGGG---ATGGTT ATGTCGGGTCAGTTCAGT-AAGGATAATAGAGAAGCCAAGG---ATGCTT ATGTCAGGTTAGCTCAATAAAGGGTATTAGAATAGCTGGTG---ATGATT ATTT--------CTTATTTCTGAACGGTCAGATGGCTGGTGACTACTACT ** * * ** * * 1150 T-ATGAAAGCTGCGCGTTGTT---CC-GCGTTCTCTCGGTGTGCCTGGCC TCCTAGACGCTGCACACCAGTAGCTC-TCATCCTCTTGGCGTGCCTGGCC TTCTAGATGCTACACAGCGTTAGCTC-TCATCCTCTTG--GTGCCTGGCC TTATAAAAGCTACACATTGTTTGTTCCCCCTTCTGTTGGTATGACTGGCC TCATGAAAGCTCACTGCACTT---CC-CTCTCTTCTTTGTACACGTTGCC * * * *** * * * * * * *** 1200 TTTTATGTGGCACTCTGTATGTCAGTT-TGTGTCCTTCATGTGCT--GA- ATTG-TATGTCACTCCATGTGTCCTTT-TGTGTCATTTGTGTACT--GG- ATTT-TATGTCACTCCATGTGTCCTTT-TGTGTCATTTGTGTACT--GG- TTCTACATGTCACTCCATATAGCTTTTTTTTGTCCTTTTTCCCCCCTTT- TCTCA--------GTCACAATCCCCTT-TGTGTACCT-ATGCACC--AAC * ** * *** * * * 1250 -TGTGATTACACAAACACCATGCACTCTCTTTTCATATCAGAGTACAGGA -TGTGATCACACAAACACTATATCCTGTCTCTTAGCAGCAG---ATAGGA -TGTGATCACACGAGCACTGTCCCCTGTCTTTTAGCAGCAG---ATAGGA -TGTCAT-GTACTGA---TGTCCTTTCTCTTTTAATATTATAGTACAGGA ATGCGATAGCAAAATGCACAT-------------GGATCAAAGGATAGGG ** ** * * * * * *** 1300 CAGAGAAG----TGATCAATGTATTGGT---CTAGTGAGACTGAGATGAA CAGATAAG----TAATGGATGTGTTTGTTGCTTAGTGAGACCAAGATGAA CGGAAAAG----TGATGGGTGTGTCG-----TTAGTGAGACCGAGAGGAA CAGAGAAG----TGGTCAGTTTATTGGCT--CTAGTAAGACCA-----AG TGTAGAAACGGTTGGTCAGCTTCTTGAT---CTAACGAGACTATGATAAA * ** * * * * ** **** * 1350 AAGAAATAACCTACAGAGTGGTCTG-TAATGCCTTTTGGTTGGACTGGGA AAGAAACAACCTA--GAGTGGTG-G-CAATGCCATTTGTTTGGACTGGGA ACAGAACAGCGTACCGAGTGGTGTG-TGATGCCGAGTGTTTGGACTGGGA ATGAAACCATGTACAAAGTGGTCTG-TAATGCCTTTTGGTTGGACTGGGA AAGAAATATATTCCAAGGTAATATGATAATGCCTTTTGGTTGGACTGCTA * ** * ** * * ***** ** ******** * 1400 ACAAGTAAAAATTTCTAATAAACATTTTGAGACTTCCAGAATC-ACTTTT ACAAGCAAGGGTTGCTAATAAATGTTCTGAGACTT-CAGAATC-ACTTTT GCGAGCAGAGATTGCTCATGAG---------------------------T ACAAGTAAATGTTTCTAATAAATGTTCTGAGATTTCCAGAATC-ACTTAT ------AAACATTTCTCCCGAAGGCCCTAAGATTTGGAAAATAGATTTTT * ** ** * * 1450 GTTATCTTATCAGACCATGGGCCTGCTGAG--GGTT---GAGCAGACA-- GCTCTCTTACCAGACTGTGGGCCTGAAGGG---CCTGAGGAGCAGCCGGC GCTCTCTTACCAGACTGTGGGCCTGCAGGG---CTCGAGGAGCAGCCGGC TCTCATCTG--AGACTGTGGCCCCACTGCGG-GGCTGAGGGATAGACTGT TTTTTTAAATCAGGCCTTCAGTATGTAGAGGTGGAGGAGGAACAGACTAG * ** * * * * * ** * 1500 --GCCTGCATTCTAACATACCCTGTTCCCACCCCACGGCCA-TTCAGACT TGGGCTGTGTCCTAGCATCCATGG------CCACTTG--------AGACT CAGACTGGGCTCGAGCATCCATGG------CGTCTTG--------AGACC CAGACTGCGTTCCCGTGTAGCCTGTGTCCCGCCCACGGACAGTCCAGCCT CAAGCCACAGATTCAG--------------ATCCATGTTAAATTCAGCCT * * * ** * 1550 GCACTCAATA-CGCTGAAGTCGCTTttgttgttgttgttgttgttTGCAT GCACTAACCA-TGTGGAAATATCTT------TTGTTGTTG---------- GCACTAACCA-TGTGGAAATACCTT------TTGTTGTTGTTTGCAGC-- GCACTAAATA-TGTTGAAGGAACTG------TTGTTGTTG--TTTTGCAT GCATTTTTTAAGGTTTAATTAACTT------T--TTCCTG------GCAT *** * * * ** ** * ** ** 1600 CA------TTTGGATTTTTTTCCTGCTTTCAATACCA-----------AA --------TTTTAATATTTTTTCTGCTTTCAATACCAAAAAGGAAAAAAA --------TTTCAATATTTTTTCTGCTTTCAGTACCAAAAAGG--AAAAA CA------TTTAAATATTTTTCCTGCTTTCAATACCAAAAAGA--AAAAA CATCAAGTTTGATTTATAGTTTCTGTTTTAAATACCAAAAACA----AAA ** * * ** *** *** * ***** ** 1650 AAAATG-----CAGATGC---------TTTAAGGCCTAAACAGAATTCTG AAAAAG-----TAGATGCTTTAAGGTATTTAAGGTATGAATGGAGTTCTG AAAAAG-----TAGATGCTTTAAAGTATTTAAGGTATGGATGGAGTTCTT AAAATG-----CAGATGC---------TTTAAGGCACAAACAGAATTCTT AAAATGCTTGCCAGATGC---------TTTAAGGTAC-AACATTCTTCTT **** * ****** ******* * **** 1700 ATATGCA (miR-448) human/mouse/rat/dog/opossum AAGAATTTAAAATATGCAATTAAAGTTTG--ATATGTTTTGTCTCCC--- AAGAATTTAAAATATGCAATTAAAATTCG----ATGTTTTGACTCCT--- AGGAATTTAAAATATGCAATTAAAATTCG----GTGTTTTGTCTCCT--- AAGAATTTAAAATATGCAATTAAAATTTG--ATGTGTTTTGACTCCC--- AAGAACTTCAAATATGCAATTAAAATTGGACATGTGTTTAGAGTTCCTCT * *** ** *************** ** * ***** * * * 1750 AAGCACCTTGT-TTTttgttgttgttgttgttgttgAAGTCAGCTGATTT AAGCACCTTCC-CCC------CTCCCCT--TTTTTTAAGTTAGCTGATTT GAGCACCT--C-CCC------CTCCCCT--TTTTTAAAGTTCACTGATTT AAGCACCTTGCTTCT------CCCCCCCCCCCTTTTAAGTTAGCTGATTA GTGCACCTTGC-TTT---------------TT----AAGCTAATTGA--- ****** *** *** 1800 TCTCTTTAGAAAGAGGGTCA-----------------GCTAGAAACCTAG TCTCTTTAGAAAGAGGTTCA-----------------GCTGGGGA----- TCTCTTTAGAAAGAGATTCAGCTGAATAGAAATCTAGGCTGGGGA----- TCTCTTTAGGAAGAGGGTCA-----------------GCTAGAAACCTAT TCTGCTTAGGAAGAGGGTCA-----------------CCTGGGAAC---- *** **** ***** *** ** * * 1850 GTTTTTTGGAATTGTAAATTTTTTTTTAGTATAG----TCTGGAGAGAAA -----TAGGA--TGTATATTCTTCTTGA--GAAG----TCTG--GAGAAA -----TAGGG--TGTACATTCTTCTT----GAAG----TCTG--GAGAAA GCTGTTTGGAATTGTG---TGTTTTTA---GAAA----TCTG--GAGAAA ------------TGTA-----ATTTTTA--GAAATGCTTCTG--GGGGAA *** * ** * **** * * ** 1900 GGTCATTCAA------AAGGAAAGTACAATGGGACTTGCT--GCCCTTCA GGTCATTCCA------AGGTCAAGTGCAGAGGGACTTTGT--CCATCCTG GGTCATTCTG------AGGTTGAGTGCTGAGGGACTCTGT--CCCTCC-- GGTCATTCAC------ACGGGGAGT-AAACGGGAGTTTCCCGACTTTTTG GATTACTCAACTACAGAAGTCAGAGGGAAGAGAACATTTT----CTTTTC * * * ** * * * * 1950 TCATCTCGTTCCCGTGCCAGG--TGTGTGTTGGTCA-----------CGT ---------TCTCACACCGGC--CCATTGATG---------------AGG ---------TCTCACACCAGC--CCACTGAT----------------CGG TCATCTTGTCCCTTCACGGGG--TGTCTGTGGGTCA-----------GGG CTTTTTTGCACCTAAACAAGGTCTGTGTGTTGCTTATTGGAAGCTATTGA * * * ** * 2000 AAAAGCC-----TGGG---AAGCATCAGAGGAGTC-----------CCGG AAGAGTC---ATAGAG---ATGAGTCAGAGG---C-----------ACGG AAGAGCC---AGAGAGTCACCGTGCCAGAGG---C-----------ACAG AAGAGTGTGTGAAGAA---CAGCATCAGATGAGGCGAGAGGCAGTCTCAG GGAAATC-GGAGAAAG---AAAGATGAGAGGGGCA-----------GCAA * *** * * 2050 ATTGCTGCTGC-----------------------TACCTGGAGACAGGGT CCCGTGGTCCCacccaggaacccagggacccagggacccagggaccGG-- CCCACAGTCCC-------------------------CGCAGGGACCAG-- CTTGCTGCTCC-----------------------TACCTAGACGGGGG-- CTGGTTGTTCT-----------------------TGTGTGATGACAGCAG * 2100 TAGCAAAATAACACTAGTGATGAGGGAGA------G----GCTTCTTTTC TAACAGAGTAACACTAGTAACTTCTT--------------TTGTGCTTTT TAACAGAGGAACACTAGTAACTTTTT--------------TTATGTTTTT TAGCATAATAACACTAGTCATGCCGTAGGGTTT-GG----TTTTGCTTGT GATTAGAACAACACTAGooooooooooooooooooooooooooooooooo * * * ******** 2150 ACCATAAGCCTGCTGTGTACACCGAGGGCGGCAGGAGAA--GCATGGGAA ATCATAAACCTGCTGTGTAGCTGAAG---GGGAAGGCAA--GCACAGGAT ATCATAAACCTGCTGTGTAGCTGAAG---GGGAAGGAAA--ACACGGGAC ATCCTAAGCCTGCTATGTAATCAGAAAATGGCAGGAAAA--ACGTGGAGA oooooooooooooooooooooooooooooooooooooooooooooooooA 2200 GGAGTCAGCCTAAG-------------TTTGCACATTGCATAAAGGGTAC GAAGTTAGCCTCCG------------CTCTGCGTGTGAC-TCACAGGGAC GAGGTCAGCCTACGCTGTGTGTATGACTGTGTGTATGAC-TCACAGGGAC GGAGGTGGCATAAG------------TTTTGCACATCGC-TCACAGGGGC ACAGCCAGCCTGTT-------GCTGAATTAGGGAATTGG-CAGAGATGGT * ** * * * * 2250 ACTAAGGTATG----AGCTGAAGCTTTAGGTTCTCCGTGCTTCC------ ACTGAGGCACA----AGATAAAACCCT--GCTCACCTAGCGTGT------ ACTAAGGCACATACCTGATAGAACCCT--GCTCGCTGAGCAT-T------ ACT-AGGCAAG----AACCGAGGCCGTAGGTTCTCTTTGCT--------- TTAGGGAAGAA----GAATCAAGGGATAAATTTGCCATTCTTCCAAAGCA * * * * * 2300 ---CTCAAGACCTCCTTCT--TGCTAACAGAA----GCA-GT------AG ---TTGCATGCCCTTCCCTCCAGTGAGCAGAGCAGCGCT-GTGCTACAGG ---TTGCATGCCCTCCCCTCCAGTGAGCAGA-----GCT-GTGCTCCAGG ----------TCTCCTTCC--TCTTAGTGGAA----GCA-GC------AG ACAACATAGGCTTTCTCTA--AGCTAATGGCA----GTACAT------CA * * * 2350 GCAATT-GCTGCAGTGCG-----TT---TCTCACCCTGCCAATAGGTC-- GTGGCT-GCTGCCGTGGT-----TT---TCTCCGTCTGCCGGTGGCTCTG GTGGCT-GCTGCAATGGC-----TTCGCTCTCTCCCTGCCGGCAGCTCTG GCAGTTTGCTGCAGTGGG----------TCTCGTGCTGCCAGGACATCTG GCAGGT-TTTGTTGTAGGAATGCCT---CTTGGCTTTGCCAAAAAGCT-- * * ** * * **** 2400 TGTCTGTATCTCTGTTAAGGAAAAT--------AGCCTGGTCCCTCCTGG TGTCTGTCTTTGTGCCCAGGCTACTTTGCTTGAGATGTGTTCCCCCTCAG TGCCCATCTTCCTGCCCAGGCTGTTTTCCTTAAGGTCTGCTCCGCCTCGG TTCCTCTCTGCACGCCCGGGCTGCTTTCCTGGAGAATGGCTCCCTCCTGG CATTTCT---CCTACCAAGCATATT------------------------- * * * 2450 CAGTGCTTGG--------------------------AAGCTTGATGCTAA CAGTGT--TG--------------------------AGACTTGGTGATCA CAGTGC--GGCTTCGGCAGTGCGGCCTCGGCAGTGCGGGCATGGTGATCA CGATGCCTGA--------------------------AAGCGCGATGCTAG --ATGATTAA--------------------------GAAATAGATGCTGT ** * ** * 2500 TTTTT---ATATAGCGTGGCAAACTGACCAGCAGTG-------CCAGGCC TCTC----GGATGGTGTGGCAGGCAGAGCGGCTGTG-------CCAGGCA TCTG----GGATGGTGAGGCAAGCAGGGTGGCCATGCCCGGCTCCAGGCA TTCCT---GGGGAGCGTGGCAGGCGCAGCAGCAGTG-------CCAGGCC TGCCTGCAATTTAGAATGGCAAACAGGTCAGTACCA-------CCAGATC * * **** * * **** 2550 TTGATCTGT------ATTCTGCACTATCCCTTTACTTGGTTCCTGGCACT CCAGGCTT------------GTTCTGTCTTTCT-CTTGGTTGTGAGCGTG CTGGGCTC------------ATTCTGTCTTTGT-CCTGGTTATGAGCACT TCTGTGTGT------CCTCTGCACCATCCCCTT----------------- TTTGATTTTCAGTGAATTAGGCTCTAATCCCAT---------CAAGCTAC * * * 2600 GAATGGTC-TCCAGCCCTGAAGAATC-----------------ACGTGTG GCGTGGTA-TCTAGCCATGAAGAGTCCGGTGTCGGG-CGGTATGGTTATG GAGTGGCC-TCTAGCCGTGCAGAGTCAGGTGTCGCT-CGGTATGGTTAAG -CGTGCTTGCCCCGTCCTGAGGAGTC----ACTGCGCCCGTACACCTGGC CATTTGT------------------------------------------- * 2650 --ATCACAGCAGCT-GACCTGGGCTTTCTCCCCGAGAGG----AAGGGGC --ACCAGAGCAGCT-GATCTT-CCCTTTCCTCCAAGGAA----GAGAGGC --ACCAGAGTAGCT-GACCTTGGCCTTTTCTCCAAGGAA----CAGAGGC AGACCCCAGCAGCCTGGTCCTGGCTTTCTCTACACGGGA----AAGGGGC ATTTCCTAGCAGCTAAGTTTTGGCACACTCCCCAAGGGATAATAAATAGC * ** *** * * * * * ** 2700 -A----TGTCATTTTTATTTGACAG----AGGGAAAA----TGGGAGCTG -GCGCATGCCGTTCTCACTTGGCAG----AGGGGCGA-------GAGTGG -G----TGCTGTTTCCACATGGC------GGGGGAGA-------GCATGG AG----CGTTGTTGTCATGCGCCAG----AAGGAAGA---AAGATGGTTG -A----TATGATTTTCATTTGATAGAAAGAAGGAAAAAATAAGTGACCCA ** * * ** * 2750 TCCTTGACTGCCT----TTGTTGTGCTTTCCCGCGTAAGATAGCACTGTG GCTCTGCCTGGCT---GCTGCTGCTGCTGCTGGAATA----GTCTCCATG TCCTTGCCGG------------GCTGCTGCTGGAGCA----GTCTCCATG TCTTTGCCTGACT-CCTCCGTTGTAGTCTCAAGCATAAGGTAGCACTGTG TCTTTGCTTGACTGCTGCCATTGTAGCTATATACATAAGATAGCACTGTA * ** * * * * * * 2800 TTTTAAACTG----TTGCATTACACTGTCTTTGCAATGA---TGTAAATG TTTTAAACT-----TTTCATGACACAGTCC--ACAGTGA---TATAAGTC TTTTAAAGT-----TTTCATGACATAGTCC--GCAGTGA---TGTAAGTC TTTTAAACTG----TTTCATTACACTGTTGTTGCAATGATGTTGTAAATG TTTTTACCTTTGATTTTCATTACACTGTCTTTGCAATGATGTTTTAAATG **** * * ** *** *** ** ** *** * *** * 2850 TAAGAAATCACTTAGCTTTAAAAGCGCAGTGGTTTGATCTTATTTATATG CAAGAAACTGCTTAGCTTTCAAAGCCGAGGGCTCTGGTCTGGACTGT--- CAAGAAACTGCTTAGCTTTCAAAGCCGAGGGCTCTGGTCTGCACTGT--- CAAGAAATCACTGAGCTTTAAAAGCTGAGTGA-TTGATCTTATTTATGTG CAAGAAATCACTTAGCTTTAAAAGCTAAGCAGCTTGGTCTTACTTATATT ****** ** ****** ***** ** ** *** * * 2900 AAGA--CTTTTTAACAT-ATCAAGAATTAGGTGCATTGGCAGGTAGGGTT --GA--CTGT----TACAGTCAAGAGTTAGGTGCATCAGCAGGTTAGGTT --GA--CTGT----CAT-GTCAGAAGGGAGGTGCATCCGCAGGTTAGGTT AAGCCCCTTTTTTACAT-ATCAAGACTTCGGTGCATCAGCAGGTCGTGTT AAGACCCCTTTTAATGG-ATCAAGAATTATATGCATCAAATGGTGGCATT * * * *** * ***** *** ** 2950 TGGGGT--------------GTGATAACTGCTTCAGATGGAATGTTCACT TGGAAC--------------ATGACACCTGCTTCCGATGGAATG-TCACT TGGAAC--------------GTGATGCCTGCTTCTG-TGGAATG-TCACT TGGATGTGTAAGGGTCCGCAGTGACAACTGCTTCGGATGCAATGTTCACT CAGACGTGTGAAAGTCTGCAATGATAACTGCAGAAGATGTAATATTCCCT * *** **** * ** *** ** ** 3000 TAAGCTTTGTCTTCTTAAAAATT-ATCAATGTGAATGTCATAATTATATA TAAGCTTTGGGTTCTTAAAAATT-ATCAATGTGAATGTCATAAT--TATA TAAGCTTTGCGATCTTAAAAAGT-ATCAATGGGAATGTCATAAT--TATA TAAGCTTTGTCTTCTTAAAAATTGATCAATGTGAATGTCATAATTATATA TAAATTTTGTTTTCTTAAAAATT-ATCAATGTGAATGTCATAATTATATA *** **** ********* * ******* ************ **** 3050 GTGCAAA (miR-507) human/mouse/rat/dog/opossum TA--TTTTTGTGGAAA---------ATTTTCTCCTAAGTATAAGTTATTG TA--TTTTTGTGGGAA---------A--ATCTTCTAAATATAAGTTATTG TA--TTTTTGTGGGAA---------A--ATCTTCTAAATATAAGTTATTG TATATTTTTGTGGAAA---------A-TTTCTCCTAAGTATAAGTTATTG AA--TTTTTGTGGAAATGGGAATTTA-TTTCTCCT-ATTATAAGTTATTG * ********* ** * *** ** * ************ 3100 TGCAAAATA---TAGTGTCATTGATGCAAATAATAGTTTAACTTTTAGTT TGCAAAATA---TAGTATCATGGACACAAATAATAGTCTAAGGTTTAGTT TGCAAAATA---TAGTATCATGGACACAAATAATAGTCTAA-CTTTAGTT TGCAAAATA---TAGTACCATTGAAGCAAATGATAGTTTAACTTTTAGTT TGCAAAGTATAGTAGTATCGTTAAAGCAAATGATAGTTTAACTTTTAGTT ****** ** **** * * * ***** ***** *** ******* 3150 ATATGCA (miR-448) human/mouse/rat/dog/opossum TAGAACTCCTAAAAGATATAAATTGTA-TTGCATATGCATTAA------A TAGAGATCCCTAAAGATATAAACTGTA-TTGCATATGCATTAA------A TAGAGATCCCTAAAGATATAAACTGTA-TTGCATATGCATTAA------A TAGAAATCCTAAAAGATATAAATTGTA-TTGCATATGCATTAA------A TAGAATCCCTCAGAGATATAAAGTGTATTTACATATGCATAAGCAAATTA **** ** * ********* **** ** ********* * * 3200 GTTTGTT (miR-495) human/mouse/rat/dog/opossum AGTTTGTTTTATTTAA-TTTTATGTAGATGTGTGAAGTG-TTAGGTAAAA AGTTTGTTTTATTTAA-TTTTCTGTGAACATGTAAAGTG-TTAGGTAA-- AGTTTGTTTTATTTAA-TTTTATGTAAACATGTAAAGTGTTTAGGTAA-- AGTTTGTTTTATTTAA-TTTTATGTAGGTGTGTAAAGTG-TTAGGTAAAA CGTTTGTTTTATTTAATTTTTACATAGGTGTGTAAAATA-CTAGGAAAAG *************** **** * *** ** * **** ** 3250 TACTTGA (miR-26a,miR-26b) human/mouse/rat/dog/opossum TTT-TTTTCACTTA-TCCATTTAAACACCTTGTTACTTGAATATTGTGTT TTC-TTTTCCCTTA-TCCACGTAAGCA-CCTGTTACTTGAATATTGTGTT TTC-TTTTCCCTTG-TCCATTTAAACACCCTGTTACTTGAATAT--TGTT ATTGTTTCCACTTA-TCCATTTAAACACCTTGTTACTTGAATATTGTGTT TTT-TTCCCACTTAACCCATTTAAACACCTCGTTACTTGAATATTGTGTT * ** * *** *** *** ** * ************* **** 3300 GACTGGTCTGCA---ACAGTGATCCATTCTGTAATATAGCT------CTT GACCGGCCAGCG---GCAGTGATCAATGCTGTACTCTAGCT------C-- GACTGGTCAGC----ACAGTGATCAACTCTGTAATGTAGCT------C-- GACTGGTCTGAA---ACCGTGATCGATCCTGTAACATAGCTCGCGAGC-C AACTGTTCTTGAAACACAGTGATCAATTTTGTAATATAGCT------CTC ** * * * ****** * **** ***** * 3350 TTAACTGGGAAG-GAACCACACCCCAGTTGTGCCGAT--TACATTA---- TTTCCTCAGAGG---CCCTGGCCTCGGCCGTGCTGGT--CAGATGA---- TTCACCCAGAGG-TCCCCATGCCTCAGTCGTGC-GGT--CAGATTA---- GAGCCCGGAAGG----CCGCGCCTCTGTTGTGCTGAGATCGCGGTGGCTC GTAACCAAGGAAATGACTATGCCTCAGTTGTGCTTAA--TAGTTGA---- * * ** * * **** 3400 -------GTGTTGGCACACAGTCGG------GTGCTAGT----------- -------GTGTTGGCACACAGTGGGTGCTGTGTCAGAGGTTC----ACAA -------GTGT---CACACAGTGGGTGCTGTGTCCCAGG---------AG CGGTCGGGCGCTGGTGT-CCGCGGGAGCCGGCGCTTAGC----------- -------GCAATTGTGGACAATTAGAGTAG-ATGCTACTGTCCACAGGAG * * * * 3450 -----------------------------------------GTAACACAA CAGAGGGTC--------------------------------ACAGCACAC CAGAGGCTC--------------------------------ACAGCATAC -----------------------------------------GTGACACAC CCATAGGTAGTGTGTGtatagatatctatatagatatctatataACACAA ** * 3500 ATGCCGCGTT--GTCTGGGTGTACAGTGTTTGTGG-------AGACGCCA CCACTGCC-----TCTTTGTTTA-----TTTGTCA-------AAACAG-- CTGCTGCC-----TCTTTGTTTA-----TTTGTCA-------AAACAG-- CCACTGCGTA--GTCCGGGTGCA-----CTTGTACCCACC-GGGACACCC TGGCTATGTTGTGTCTTGATAAA-----TTCATTACCAATAAAGATACTG * ** * * * * * 3550 CTTCCTCAA-AATGGTTTTTGATTGTTTTTAACCTATAAGACG----TTC CTTCCTAAA-GAAGGTTTCAGAGAGTTT-----TTGTAAGACCTTCCCAA CTTCCT-AA-GAAGGTTTCC-ACAGTTT-----CTGTACGACC-CCCCAA ATTCCTCAA-AATGGCTTTTGCTAGTTTTTAACCTGTAAGACC----CTT ATTTCCCAATAGTAATTTGTAAAAGTTTTCAACCCAGAGGATC----CCT ** * ** ** **** * ** 3600 TGATGCTCAC--AAACCTCT--ATTCAACACACAAAACAAACATGAAAAG TGGTGGTTAC--AAACCT-T--AATCAAAAA---------------CACA TGGCGGTCAC--AAACCT-T--AATCAAAAC---------------AACA CGCTGGTCAG--CAACCTCCCGAATCAAAAG-----------ATGAAAAG TACTGGTCACATAAGCCTCT--AATCTACA----------------GAAG * * * * *** * ** * * * 3650 G------TAGTTAGTTGGGTTGTAACA-GCTTACTGGGGTGGACTCATAA G------AAG----GTGA-----CAAA-GCTTACTGTGGTGGGCTCATGA G------AAGT---TTGA-----CAAA-GCTCATGGTGGTGGACTAATGA GAACAAATTC----TTGCGTTTTACAA-GCTTACTGCGGTGGACTAATTA G------TCA----TTGGGTTTTAAAACTCTAACCATGGTGTTC----AA * ** * ** * **** * * 3700 AACAGTGGCTTTCTGTTCATCTAA--AGTTTCCTCAGAT-ACCACAGACC AGCAGGAGT--CCTG-TTAGACAG-----TTTCCC-AGC-GCTGC----- AGCAGGAGC--TCTGTTTATACAG----TTTTCCC-AGT-GCTGT----- AGCAGTTGTTTTCTGTGTATAAAG---GTTCCCTCAGAT-ACCACACACC ACTAGTTTTTAAAAATTCCTTTAAAAAGTTCTTTTAAACAAATTTACACC * ** * * 3750 ACTGTTAAGTGTGCTCATTGTCACTTTAAATTTCAACGATACCCTAT-TT -CT-CTGAGTGAGCTCAGTGACACTTT-AA-TTCAGCTCCGCCC-AC--T -GT-CTGAGTGAGTTCCGTGTCACTTTAAA-TTCAGCTCTACCCTGC--T ACT-ATACGTGTGCTCATTGTCACTTTAAATTTCAACTATGCCCTAT-TT ACT--GAAATGTACTCATTGTCACTTTAAATTTAAACCGTGCCCTTTATT * ** ** ** ****** ** ** * * *** * 3800 TTGTCATTCTAAATATCAGATGTACTATTGGTATAATTGCACACCAAAAA TCGTCTTTCTCACTATGAGATGTACTATTGGTATAATTGCACACCAAAAA TCGT-TTTCTGACTATGAGATGTACTATTGGTAAAATTGCACACCAAAAA TTGTCTTTCTGAATATCAGATGTACTATTGGTATAATTGCATACCAAAAA TTGTCTTTCTAAATATCTGATATACTGTTGGTATAATTGCACACCAAATA * ** **** * *** *** **** ****** ******* ****** * 3850 AACTGGA (miR-145) human/mouse/rat/dog TAAGCCAAACAGTGCATTAC--------GCTAACTGGATCCCTGCTTTTA TAAGCCAAACAGTGCATTAC--------ACTAACTGGATCCCTGCTTTCA TAAGCCAAACAGTGCATTACATACACTAACTAACTGGATCCCTGCTTTCA TAAGCCAAACAGTGCATTAC--------ACTAACTGGATCCCTGCTT--A TGAGCCAAACAGTGCATTAT-------AGCTCACTGGGCCACTGCT---A * ***************** ** ***** * ***** * 3900 TGTGAGCTAAGGAAAG--------------ATGGAGCCAACTC------- TGGAAGCAAAGGAAAG--------------AC------------------ TGTAAGCAAAGGAAAG--------------AC------------------ ACGGAGCAAAGGAAAG--------------CCGGAGCCAGCTC------- GGTGAGCCCAGGGCAGCCACGGACTCCTCAATTGAGCCAAGGCCCTACAT *** *** ** 3950 --------------CAACGAGGGCCTCTTTTTCTCTCTTG--TCT---AG ----------------ACG--------------TCTCACGTCTCT---GT ----------------ACG--------------TCTCACG--TCC---GT --------------ACACGAGAGCCTCGTTTCCTCTCTCG--TCC---AG ATGGCGCCAACCAGAAATAAGAGCCTCTTGATCTCCCCTG--TTTTAAAG * ** * * * 4000 CCTGTTTCTAAACCGAATGATCCAGGATTCAAGCTTCTATTGTCAAGTGA CCTGTTTGTACACCTAGTGACCCAGGATTCAAGTTTTTAGTATCAAGTAA CCTG-TTGTACACCTAGTGACCCAGGATTCAAGTTTTTAATATCAAGTAA CCTGTGTCTAAGCCCAGTGA-CCAGGATCCGAGCTTTCAGTATCAAGTGA TCTATT-----GACGAATGACCTAGGATTCAAGCTTTTGAAACAAAATTA ** * * *** * ***** * ** ** ** * * 4050 AACTTT---CCTCAGATGGACTCCAGGTAGCC---AGGTCACCTAAACCT ACTTCG---CCTCAGACTGACTA-AGGCAGCT-GTAGGTCATCTGAGTCT GTCTTG---CCTCAGACTGACCACAGGCAGTC-TGAGGTCACCTGAGTCT AACTTGG--CTTCACGTTGACTCAAGGTAGTT---AGCTAATCTGAATCT ATCCCTGTTCTCTTTATTGACACGAGATAGTTTTTAGCTAGTCTGATGCT * *** ** ** ** * ** * ** 4100 AGTGGTCCTGTGC----GATG----------------CTCTTTCTGCCAG AATGCTCGTGTGC----AATG----------------CCCTTCCCGCCTC AATGACCGTGTGCAATGAATG----------------CCCTTTCCGCCCC AGTGATCTTGTGC----AATGCTCAAA--AGCAAACCCTCTCCCCGCCCC GATGATCTTGTGC----AGGGGCCTAATTGCCTATAGTCTTTTCAGCCAC ** * ***** * * * *** 4150 AAGCACA (miR-218) human/mouse/rat/dog/opossum TCCCTGAATCTCTGCAGCTTCTCTTACCTGTCTTACCTGTAGTAAAGCAC TCCC-GGGTCTTTGCAGCTTCTCCTCACTGT---------AGTAAAGCAC TCCCTGGGTCT---CAGCTTCTCCTCACTGC---------AGCGAAGCAC TCCCGGGATCCCTGCGGCTTCCCCTCCTTCC---------AGTAAAGCAC TCCCTGGATTTGTGGAGCTTTTTCTGTTGAT---------CGTGAAGCAC **** * * **** * * ****** 4200 AATTGCAGTGGCGTCG----CA-TTCAGAAGAAGGGAAGGTCAGCAGAGG AATTGCAGGAGCGTCCGTCACGGCTCAGAAGGA------GTCAGT--AGT AATTGCAGGAGCGTCT----CAGTCCAACAGGA----AGGTCAGCAGAGT AATTGCAGCAATGTTA----CAATTCAGAAGAA-GGAAGGTCAGTAGAGT AATTGCAGTAA---------CAGTTCAGAAGAA-GGAAGGTCAGTATAGT ******** * ** ** * ***** ** 4250 CTATGCA (miR-153) human/mouse/rat/dog/opossum TGTTTAC (miR-30a-5p,miR-30c,miR-30d,miR-30b,miR-30e-5p) human/mouse/rat/dog/opossum CTATGCATGTTGTGTGATGATGAGTGTTTACAGCCACCTTCTCCT-AAAA CTATGCATGTTGTAAGATAATGAGTGTTTACAGTCGCCTTCT-CT-AAAG CTATGCATGTTGTAAAGTAATGAGTGTTTACAGTCTCCTTCT-CT-AAAA CTATGCATGTCGTGTGATAATGAGTGTTTACAGTCACCTTCTCCGAAAAC CTATGCATGTTGTATAATAATGAGTGTTTACAGTCATATTCTCTG-AAGA ********** ** * ************** * **** ** 4300 CGAA-ATTTATACCGGGGTGGATAGTAT------TCCATTAGGTAGA-CT TGAGCATTTATACTGGAGTGGGTAGCAT------TCCATTATGTAGA-CT CGAACATTTATCCTGGAGTGGATAGCAT------TCCATTATGTAGA-CT TAAA-ATTTATACTGGAGTGGATAGTAT------TCCATTATGTAGA-CC TGAAAATTTATACTGGATTGTATAGTATTATTATTCCATTATGTAGATTT * ****** * ** ** *** ** ******* ***** 4350 TATCGACTTTGCTAAGTGCTTTTTAGACAGCTTAAAAAATTTTCAAGATT TC-AAACTTTGCTAAGTGCTTTTTAGATTGCTTAAAAATTTTTCAAGATT TA-AAACTTTGCTAAGTGCTTTTTAGATTGCTTAAAATTTTTTCAAGATT TATCAACTTTGCTAAGTGCTTTTTAGATTGCTTAAAAATTTTTCAAGATT TATCAATTTTGTTAAGTGCTTT-TAGACAGCTTAAAAGTTTTTCAGGATT * * **** ********** **** ******** ****** **** 4400 TTAAAAGATGTATAAGGTTAAGTTTGCAAATATAATGGAAATGCTGTATA TTAAAAGATGTATAAGGTTAAGTTTGCAAATATAACGGAAATGCTGTATA TTAAAAGATGTATAAGGTTAAGTTTGCAAATATAACGGAAATGCTGTATA TTAAAAGATGTATAAGGTTAAGTTTGCAAATATAATGGAAATGCTGTATA TTAAAAGATGTATAAGGTTAAGTTTGCAAATATAATGGAAATGCTGTATA *********************************** ************** 4450 TCTTTTGAAGTGATGAAATCCACGTTGGAATTTTAAAGAAAATATGTTGT TCTTTTGAAGTGATAAAATCCATGTTAAAATTTTAAAGAAAATATGTTGT TCTTTTGAAGTGATAAAATCCATGTTAAAATTTTAAAGAAGACATGTTGT TCTTTTGAAGTGATAAAATCCACGTTGGAATTTTAAAGAAAATATGTTGT GCTTTTGAAGTGACAAATTACACGTTTGAATTTTAAAGAAAGTATGTTGT ************ ** * ** *** ************ ******* 4500 AATAATGCTGTTGTAAGTAATATTTT-AATGTCTCTT--TGCCTGTTTTC AATAATGCTGTTGTAAGTAATATTTC-CATGTCTCTC--TGCTTGTTTTC AATAACGCTGTTGTAAGTAACATTTC-CATGCCTCTCTTTGCTTGTTTTC AATAATGCTGTTGTAAGTACTATTTT-AATGTCTCTTTCTGCCTGTTTTC AATAATGCTGTTGTAAGTAATATTTTAAATGTCTCTTG-GGCCTGTTTTT ***** ************* **** *** **** ** ****** 4550 AGCATTA (miR-155) human/mouse/rat/dog/opossum TAT--TTCAGCACATTCATTGTGGTGAATGTTCATAGCATTATAA--CTG TAG--TTCAGCACAGTCATTGTGGTGAATGTCCATAGCATTATAA--TCG --G--TGCA-----------------AGTGTCCATAGCATTATAA--CTG TAT--ATCAGCACACTCATTGTGGTGAATGTTCATAGCATTATAA--TTG TATTATTCAGCACATTTATTGTGGTGAATGTTCATAGCATTATAAACTTG ** * *** ************* * 4600 CTTAGCCATTGA---ATGATAA-----CATTTGT---------------- CTTAGCCATTGA---ATTATAA-----TATTTGT---------------- CTTAGCCATTGAGTTATTATAA-----CATTTGT---------------- CTTAGCCATTGA---ATGATAA-----CATTTGT---------------- CTAAGCCATTGA---AAGGTAAAAGGTAACTTGTTTTTCTGATTATCATT ** ********* * *** * **** 4650 ------------------TAGTGGAAATTG-GAAAATTTATTTGTGAAAT ------------------TAGTGGAGATTG-GGAAATTTATTTGTGAAAT ------------------TAGTGGAGATTG-GGAAATCTATTTGTGAAAT ------------------TAGTGGAGATCGAAAAAATTTATTTGTGAAAT TTATTGTAAATGAAATTATAGTGGAGATGG-AAAAATTCATTTGTGAAAT ******* ** * **** *********** 4700 TCTGCAGAATTCATTTTTCT------ATTTCCAATATTTGCTGAGGTTAA TCTGCAGAATTCATTTTTCT------ATTTCCAATATTTGCTGAAGTTAA TCTGCAGAATTCATTTTTCT------ATTTCCAATATTTGCTGAAGTTAA TCTGCAGAATTCATTTTTCT------ATTTCTAATATTTGCTGAAGTTAA TCTGCATAATTCAGTTTTTTTCTATGATTTGCAATGTTTGCTGATCTCAA ****** ****** **** * **** *** ******** * ** 4750 AAGCCAT (miR-135a,miR-135b) human/mouse/rat/dog/opossum AT-AAAAA-TTTTCAAGCCATTGATGTAATAAAATATGAAATGAAAGCAT AT-AAAAA-TTTTCAAGCCATTGATGTAATAAAATACGAAACAAAACAAC AT-AAAAA-TTTTCAAGCCATTGATGTAATAAAATATGAAACAAAACAAT ATAAAAAA-TTTTCAAGCCATTGATGTAATAAAATACAAGACAGAACCAT AT-AAAACTTTTTCAAGCCATGGATGTAATAAAACACGGAGTCAAACCAC ** **** ************ ************ * ** * 4800 TTTCTGC--AC-CCCCA---CGCT---CCATCAAAGCAGTACCCTTCCCT GTAATGC--AT-CGCTA---TGTC---CCGTC-------------TTCCT TTTTGGT--AT-CCCTA---TGTCCATCCATC-------------TTCCT CTTCTGC--ACAGTCCA---CTTC---CCACCAGAGCAGTGCCCCACCCT CToooooooooooooooooooooooooooooooooooooooooooooooo * 4850 GTAACAAAGTGG----G---GTTCTTTCTTTCCTTTT----AAGTG-AGG ---ACAGCCTGG----G---GTT-GTTCCCTCCTTGC----AGGCA---G ---ACAGAATGG----G-GTGTT-TTTCTCTCCTTCC----AAGCA--GG AACAGATAGCAG----G---------------CTTTT----GCGTTGGGC oooooooooooooooooooooooooooooooooooooooooooooooooo 4900 CTTG CCTG CCTG CTtg oooo 4950