| Focus Paper |
|
Marcotte, E.M., Pellegrini, M., Thompson, M.J., Yeates, T.O., Eisenberg, D.. (1999) A combined algorithm for genome-wide prediction of protein function. Nature 402: 83-86. (PDF) |
| Background Papers |
| The following papers describe the individual methods combined in (Marcotte
et. al. 1999).
Pellegrini, M., Marcotte, E. M., Thompson, M. J., Eisenberg, D., Yeates, T. O. 1999. Assigning protein functions by comparative genome analysis: protein phylogenetic profiles. Proceeding of the National Academy of Sciences USA 96:4285-4288 (PDF) Marcotte, E. M., Pellegrini, M., Ng, H.-L., Rice, D. W., Yeates, T. O., Eisenberg, D. 1999. Detecting protein function and protein-protein interactions from genome sequences. Science 285:751-753 (PDF) Eisen, M. B., Spellman, P. T., Brown, P. O., Botstein, D. 1998. Cluster analysis and display of genome-wide expression patterns. Proceeding of the National Academy of Sciences USA 95:14863-14868 (PDF)
|
| Relevant Links |
| A web page for accessing the functional predictions made by the combined
algorithm is available at http://www.doe-mbi.ucla.edu/people/marcotte/yeast.html
as part of the website for the UCLS-DOE
Lab for Structural Biology and Molecular Medicine.
The paper also relies on data from the MIPS
Yeast database, DIP database,
and Swiss-Prot database.
|
| Presenter |
| James Galagan (jgalag@mit.edu) |
 Journal
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