J. Gustav Smith

J. Gustav Smith
J. Gustav Smith, MD, PhD, is a physician at the department of Cardiology, Skane University Hospital in Lund, Sweden, and a research fellow in the laboratory of Chris Newton-Cheh and the laboratory of Olle Melander. Gustav received his MD and PhD from Lund University.

Gustav's primary interests are in prediction and prevention of the major cardiovascular diseases, including sudden cardiac death, myocardial infarction, ischemic stroke, atrial fibrillation, valvular heart disease and heart failure. He pursues systematic approaches in molecular epidemiology, including genome-wide association studies, resequencing and novel approaches in proteomics, to identify novel risk factors which may improve risk prediction and advance understanding of human pathophysiology. Phenotypes under study include both manifest cardiac disease and intermediate phenotypes reflecting cardiac structure and function. To this end he is working with several large, well characterized cohorts and in international collaborations.

Email: gustav [at] broadinstitute.org

Recent publications:
Melander O et al. Novel and conventional biomarkers for prediction of incident cardiovascular events in the community. JAMA 2009;302:49-57.

Smith JG, Newton-Cheh C. Genome-wide association study in humans. In Cardiovascular genomics: methods and protocols. 2009. ed. Keith DiPetrillo.

Smith JG, Newton-Cheh C. Candidate gene and genome-wide association studies. In AHA Clinical Series: Cardiovascular Genetics and Genomics. 2009. ed. Dan M Roden.

Smith JG et al. Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. Heart Rhythm 2009;6:634-41.

Smith JG et al. Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study. Circ Cardiovasc Genet 2009;2:159-64.

Lowe JK et al. Genome-wide association studies in an isolated founder population from the pacific island of Kosrae. PLoS Genet 2009;5:e1000365.

Smith JG et al. Distribution and Correlates of Midregional Proadrenomedullin in the General Population. Clin Chem 2009;55:1593-5.

Smith JG et al. Atrial fibrillation in the Malmo diet and cancer study: a study of occurrence, risk factors and diagnostic validity. Eur J Epidemiol 2010;25:95-102.

Newton-Cheh C, Smith JG. What Can Human Genetics Teach Us About the Causes of Cardiovascular Disease? J Am Coll Cardiol 2010;55:2843-5.

Smith JG et al. Assessment of Conventional Cardiovascular Risk Factors and Multiple Biomarkers for the Prediction of Incident Heart Failure and Atrial Fibrillation. J Am Coll Cardiol 2010;56:1712-9.

Kenny EE et al. Increased power of mixed-models facilitates association mapping of 10 loci for metabolic traits in an isolated population. Hum Mol Genet 2011; 20: 827-39.

Smith JG et al. Genome-Wide Association Studies of the PR Interval in African Americans. PLoS Genet 2011; 7: e1001304.

Ellinor PT et al. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet 2012: epub 29 april.

Smith JG et al. Genetic Polymorphisms for Estimating Risk of Atrial Fibrillation in the General Population: A Prospective Study. Arch Intern Med 2012; 172: 742-4.