Update: I'm moving to Vienna to lead the Medical Epigenomics Lab at Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences. Keep in touch!
Personal website: http://christoph-bock.org/
Lab website: http://medical-epigenomics.org/
Personal Website: Christoph Bock
Overview
My research focuses on computational epigenetics, stem cell research and predictive biology. I pursue the following long-term goals:
- to use bioinformatic prediction for optimizing pluripotent stem cell differentiation into clinically relevant cell types
- to discover and validate epigenetic biomarkers for personalized cancer treatment
- to develop computational methods and software tools that are useful for researchers working on epigenetics and stem cell research
Selected Publications:
- Bock C#, Kiskinis E#, Verstappen G#, Gu H, Boulting G, Smith ZD, Ziller M, Croft GF, Amoroso MW, Oakley DH, Gnirke A, *Eggan K, *Meissner A (2010). A reference of human ES and iPS cell variation enables high-throughput characterization of pluripotent cell lines. Cell, 144, 439–452 (view preprint)
- *Bock C#, Tomazou E#, Brinkman AB, Müller F, Simmer F, Gu H, Jäger N, Gnirke A, Stunnenberg H, *Meissner A (2010). Quantitative comparison of genome-wide DNA methylation mapping technologies, Nat Biotechnol, 28, 1106-1114 [highlighted by a News & Views article]
- Gu H#, Bock C#, Mikkelsen TS, Jäger N, Smith ZD, Tomazou E, Gnirke A, Lander ES, *Meissner A (2010) Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution. Nat Methods, 7, 133-136 [highlighted on cover; evaluated by F1000]
- *Bock C (2009) Epigenetic biomarker development. Epigenomics 1: 99-110 [invited review]
- Schüffler P, Mikeska T, Waha A, Lengauer T, *Bock C (2009) MethMarker: User-friendly design and optimization of gene-specific DNA methylation assays. Genome Biol 10: R105 [marked as "highly accessed" on the journal's website]
- *Bock C, Halachev K, Büch J, Lengauer T (2009) EpiGRAPH: User-friendly software for statistical analysis and prediction of (epi-) genomic data. Genome Biol 10: R14 [cover image of the February 2009 issue]
- *Bock C, Walter J, Paulsen M, Lengauer T (2008) Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping. Nucleic Acids Res 36: e55 [cover image of the June 2008 issue]
- *Bock C, Lengauer T (2008) Computational epigenetics, Bioinformatics, 24, 1-10 [invited review; the year’s most frequently viewed paper in the Bioinformatics journal; more than 25,000 views since 2008]
- *Bock C, Walter J, Paulsen M, Lengauer T (2007) CpG island mapping by epigenome prediction. PLoS Comput Biol 3: e110 [the Max Planck Society issued a press release]
- Mikeska T, Bock C, El-Maarri O, Hübner A, Ehrentraut D, Schramm J, Felsberg J, Kahl P, Büttner R, Pietsch T, *Waha A (2007) Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis. J Mol Diagn 9: 368-381
- *Bock C, Paulsen M, Tierling S, Mikeska T, Lengauer T, Walter J (2006) CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure. PLoS Genet 2: e26 [cover image of the March 2006 issue; Max Planck Society and Saarland University issued press releases]
- *Bock C, Reither S, Mikeska T, Paulsen M, Walter J, Lengauer T (2005) BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing. Bioinformatics 21: 4067-4068 [thousands of software downloads since 2005; currently dozens of downloads per week]
* corresponding author # equal contribution citation data via ResearcherID (ISI) citation data via Google Scholar
Contact details:
E-mail: cbock@broadinstitute.org
Phone: (+1) 617-714-7706
Christoph Bock
Broad Institute, Room 6055-A
7 Cambridge Center
Cambridge, MA 02142
USA
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