Broad Workshops
BroadE workshops bring researchers in the extended Broad community together so they can learn from one another. BroadE workshops (the 'E' stands for education) offer insights and share hands-on training in breakthrough technologies, high-throughput methods, and computational tools not typically found in conventional research labs. Through this ongoing series, which is open to Broad staff and to researchers at MIT and Harvard and Harvard-affiliated hospitals, the Broad community hopes to extend the impact of its science and openly share new methods.
New Registration System
It’s official — BroadE is a rousing success! In fact, demand is so high that our workshops quickly reach capacity, sometimes only minutes after being posted.
To meet this overwhelming demand and promote access to all in our community, we will repeat our most popular workshops during the coming year.
In addition, we will implement a new registration system for BroadE workshops occurring in June 2013 and later. Going forward, when a BroadE workshop is announced, we will also open a one-week application period. Participants will be selected from the pool of applicants who register during this period. In selecting participants from this pool, we will consider:
- the applicant’s home institution
- the applicant’s lab
- whether the applicant has participated in previous workshops
This new registration practice will help us to ensure that BroadE workshops reach a diverse, balanced group of Broadies.
Upcoming Workshops
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Charting the Epigenome with ChIP ChIP (chromatin immunoprecipitation) is a very powerful technique that enables the localization of proteins on DNA throughout the genome. The technique relies on the selective enrichment of a chromatin fraction containing a specific antigen, by immunoprecipitation. Antibodies that recognize a protein or protein modification are used to capture the chromatin (protein - DNA complex), and in the contemporary method of ChIP-Seq, Nextgen sequencing libraries are derived from the recovered DNA. The libraries are sequenced and the recovered sequences are aligned to a genomic scaffold to map the locations of the antigen recognized by the antibody. The ChIP technique can be used in any area of research to further elucidate gene function and regulation in their native state. Application of ChIP to the genome wide localization of DNA binding proteins, transcription factors, chromatin modifying enzymes, and histone modifications has helped develop an understanding of the mechanisms for the regulation of chromatin organization. These methods have contributed to our understanding of embryogenesis and tissue specific cellular differentiation, while aberrant chromatin structure is associated with developmental disorders and other diseases, such as cancer. |
June 3 12:00 p.m.-5:00 p.m. |
Registration has closed |
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Modern Statistical Ideas for the Life Sciences This workshop will cover modeling and estimation basics for life scientists. The workshop is aimed at biologists who want to work closely with statisticians to develop either mechanistic or phenomenological models of cellular behavior. Statistical models can be used to gain insight into quantitative aspects of any cellular behavior of interest that are not directly measurable, and need to be inferred from indirect measurements. Model-based statistical analysis and inference are especially useful in high-throughput studies, and to disentangle small-to-medium effects from noise. If you are expecting 50-fold effects, counting will work just fine. |
June 7 11:30 a.m.-2:30 p.m. |
Registration has closed |
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Planning & Execution of Successful Small Molecule Probe Developement The goal of this workshop is to educate our community about successful probe development strategies, engage workshop participants through real-world case studies and examples, and provide a framework for follow-up interaction with the Therapeutics Platform. The course will begin with presentations on how to approach a probe development project covering topics such as Project planning, assay development, chemical libraries, data analysis and computational mining and working with the platform. The second half of the session will be working through complex fictional situations to design and execute a successful probe development project. |
June 10 12:30 a.m.-4:30 p.m. |
Registration opens May 20 at 9:00 a.m. Registration closes May 24 at 5:00 p.m. |
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