Copy Number Alterations Across Multiple Cancer Types
Welcome to Tumorscape!
This portal is designed to facilitate the use and understanding of high resolution copy number data amassed from multiple cancer types. The following functionalities are supported:
- Gene-level Analysis: One can query the level and significance of copy number alterations affecting any gene listed in Refseq (or miRNAs). Click "Analyses", then "by Gene".
- Analysis by cancer type: One can query the most significant regions of amplification and deletion in individual cancer types. Click "Analyses", then "by Cancer Type".
- Download/Browse data: Data and a user guide to this portal are available for download by clicking "Browse data" and then "Download". In addition you can currently browse the full segmented copy-number data using the Integrative Genomics Viewer (IGV) by clicking "Analyses", "by Cancer Type", choosing the dataset you are interested in viewing, and then clicking the "Peak Region" links under the "Amplifications" or "Deletions" tabs.
For a more detailed description of the methods used to analyze these data, please see Beroukhim et al, "The landscape of somatic copy-number alteration across human cancers", Nature, 463:899-905, 2010.
