The Matrisome Project
The Matrisome Project is a collaborative effort between scientists from the Hynes Lab at the Koch Institute for Integrative Cancer Research at MIT and the Broad Institute of MIT and Harvard, aimed at defining bioinformatically and experimentally the ensemble of genes encoding the "matrisome", i.e. the ensemble of extracellular matrix and ECM-associated proteins (Naba et al, 2011).
The purpose of the Matrisome Project web page is to provide information and resources relevant to research on ECM proteins and to be a platform for deploying data collections, methods, and protocols. Our aim is to facilitate the use of our protocols by other scientists and to allow their widespread use in future studies.
Collection of resources (inventories of ECM domains used to define extracellular matrix proteins, sequence files and tables) on the human and mouse matrisomes.
Experimental coverage of the in silico matrisome: http://web.mit.edu/hyneslab/matrisome/page_experimentalData.html
This table summarizes experimental proteomic data mapped to the human in silico matrisome defined bioinformatically. The data presented in this table were published in Naba et al., Molecular and Cellular Proteomics, 2011 (doi: 10.1074/mcp.M111.014647). For detailed description of the material and methods used to generate these data, please refer to this publication.
In addition, the raw mass spectrometry data are deposited in MassIVE (http://proteomics.ucsd.edu/ProteoSAFe/datasets.jsp)
- Murine lung, murine colon and melanoma xenografts data (A375 and MA2 tumors): MSV000078494
- Human mammary carcinoma xenigrafts (MDA-MB-231 and LM2 tumors): MSV000078535
Annotated bioinformatic workflow used to derive in silico matrisomes.