The Matrisome Project

The Matrisome Project is a collaborative effort between scientists from the Hynes Lab at the Koch Institute for Integrative Cancer Research at MIT and the Broad Institute of MIT and Harvard, aimed at defining bioinformatically and experimentally the ensemble of genes encoding the "matrisome", i.e. the ensemble of extracellular matrix and ECM-associated proteins (Naba et al, 2012).
The purpose of the Matrisome Project web page is to provide information and resources relevant to research on ECM proteins and to be a platform for deploying data collections, methods, and protocols. Our aim is to facilitate the use of our protocols by other scientists and to allow their widespread use in future studies.

Contact: 
Alexandra Naba: anaba@mit.edu
Publication Info: 
Title: 
The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.
Date: 
2012
Notes: 
Alexandra Naba, Karl R. Clauser, Sebastian Hoersch, Hui Liu, Steven A. Carr, and Richard O. Hynes. Molecular and Cellular Proteomics, 2012. PMID:22159717
Title: 
Overview of the Matrisome - An Inventory of Extracellular Matrix Constituents and Functions.
Date: 
2012
Notes: 
Richard O. Hynes and Alexandra Naba In: Extracellular Matrix Biology. Hynes RO, Yamada KM (Editors). Cold Spring Harbor Perspectives in Biology, 2012. PMID:21937732.
Title: 
Towards Definition of an ECM Parts List: an Advance on GO Categories.
Date: 
2012
Notes: 
Alexandra Naba, Sebastian Hoersch, and Richard O. Hynes. Matrix Biology, 2012, 31(7/8):371-372. PMID: 23199376
Title: 
Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters.
Date: 
March 2014
Notes: 
Alexandra Naba, Karl R. Clauser, John M. Lamar, Steven A. Carr, and Richard O. Hynes. eLife, 2014, 3:e01308. PMID: 24618895
Title: 
Extracellular matrix signatures of primary human colon cancer and their metastases to liver.
Date: 
July 2014
Notes: 
Alexandra Naba, Karl R. Clauser, Charles A. Whittaker, Steven A. Carr, Kenneth K. Tanabe, Richard O. Hynes. BMC Cancer, 2014, 14(1):518. PMID: 25037231
Title: 
The Extracellular Matrix: Tools and Insights for the “Omics” Era.
Date: 
July 2015
Notes: 
Alexandra Naba, Karl R. Clauser, Huiming Ding, Charles A. Whittaker, Steven A. Carr, and Richard O. Hynes. Matrix Biology, 2015, pii: S0945-053X(15)00121-3. PMID: 26163349
Title: 
Enrichment of extracellular matrix proteins from tissues and digestion into peptides for mass spectrometry analysis.
Date: 
July 2015
Notes: 
Naba A*, Clauser K.R, and Hynes R.O. (2015) Journal of Visualized Experiments, (101): e53057 PMID: 26273955