GISTIC

GISTIC is a tool to identify genes targeted by somatic copy-number alterations (SCNAs) that drive cancer growth. By separating SCNA profiles into underlying arm-level and focal alterations, GISTIC estimates the background rates for each category as well as defines the boundaries of SCNA regions.

Contact: 
Rameen Beroukhim Rameen_Beroukhim@dfci.harvard.edu, Gad Getz gadgetz@broadinstitute.org, Craig Mermel cmermel@broadinstitute.org
Publication Info: 
URL: 

http://genomebiology.com/2011/12/4/R41

Date: 
4/28/2011
Notes: 
Mermel, et al. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol. 2011;12(4):R41. Epub 2011 Apr 28.
Tool Info: 
URL: 

http://www.broadinstitute.org/cgi-bin/cancer/publications/pub_paper.cgi?mode=view&paper_id=216&p=t

Description: 

Source code and documentation.
GISTIC is also available on the public GenePattern server at http://genepattern.broadinstitute.org.