ABSOLUTE

ABSOLUTE generates absolute copy number data from a mixed population of tumor and normal DNA. This process begins by generation of segmented copy number data, which is input to the ABSOLUTE algorithm together with pre-computed models of recurrent cancer karyotypes and, optionally, allelic fraction values for somatic point mutations.  ABSOLUTE then provides information on the absolute cellular copy number of local DNA segments and, for point mutations, the number of mutated alleles.

Contact: 
absolute-help@broadinstitute.org
Publication Info: 
Date: 
4/29/2012
Notes: 
Carter, et al. Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol. 2012 Apr 29. doi: 10.1038/nbt.2203. [Epub ahead of print]