MCL1 chemical genomics
MCL1 is an essential downstream target for transcriptional repressors. BCL-xL expression is a biomarker for MCL1 essentially and resistance mechanism for MCL1 repressors.
Wei, et al. Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency.Cancer Cell. 2012 Apr 17;21(4):547-62.