Use our search function, browse the complete software collection or click on one of the software categories listed below:
Genetic Analysis: GWAS Genetic Variation Linkage Analysis Gene Expression
Sequence Analysis: Assembly Annotation Alignment RNAi RNA-seq Primer Design Next Generation Tools Phylogenetic Analysis Gene Structure Viral
NMF (Non-negative Matrix Factorization), an algorithm based on decomposition-by-parts, recovers meaningful information without supervision. Coupled with a novel model selection mechanism, and efficiently implemented in Matlab, NMF is a powerful method for identification of context-dependent patterns in complex biological systems.
PLINK is a comprehensive toolset for statistical analysis in whole-genome association studies.
Primer3 is a tool used to choose primers for PCR reactions.
PriSM is a set of algorithms designed specifically to create degenerate primers for the amplification and sequencing of short viral genomes while maintaining sample population diversity.
RC454 is a program that takes a set of 454 read and quality files as well as a consensus assembly for those reads and corrects for known 454 error modes such as homopolymer indels and carry forward/incomplete extension (CAFIE). It will also correct for any indel that breaks the reading frame, unless it occurs in more than 25% of the reads. Since the algorithm is aggressive in correcting for errors, it is important to align the reads to their own assembly rather than to an external reference to prevent misalignments as much as possible. RC454 uses Mosaik to align the corrected reads between each step, and as such it is required to run the script.
Scripture is a method for transcriptome reconstruction that relies solely on RNA-Seq reads and an assembled genome to build a transcriptome ab initio.
Siphy analyzes multiple sequence alignments and single outs bases or small regions that are undergoing selection by looking at reduction in substitution rates and unexpected detecting substitution patterns. A specific program to detect conserved transcription factor binding sites is also available.
SNAP is a web server for finding and annotating proxy SNPs based on linkage disequilibrium, genomic location, and coverage by commercial genotyping arrays.
SomaticCall is a program that finds single-base differences (substitutions) between sequence data from tumor and matched normal samples.