PriSM is a set of algorithms designed specifically to create degenerate primers for the amplification and sequencing of short viral genomes while maintaining sample population diversity.
Credits:
Yu Q, Ryan EM, Allen TM, Birren BW, Henn MR, Lennon NJ (2011) PriSM: a primer selection and matching tool for amplification and sequencing of viral genomes. Bioinformatics 27(2): 266-267.